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The Danish Oldest-old Siblings Study (DOS)

This study was launched in 2003 in recognition of the fact that there are very few genetic linkage studies of very old and healthy people. Based on the Danish Civil Personal Register (CPR) and the Danish Church Books, we managed to identify 4,500 families in which there were at least two living siblings above age 90.

In the survey part of the study, we conducted in-home visits to sets of siblings who were at least 90 years old. In most families there were two, but we also found many families with three, four and even five siblings older than 90 years.

The data were grouped in the following categories: Family, Education, Occupation, Psychological and Physical Health, Medications, Hospitalizations, Activities of Daily Living (ADL), Living Habits and Depression Symptoms. Physical abilities were tested by means of Chair Stand Test, Gait Speed Test and Grip Strength Test. Anthropometric measures were captured and Folstein Mini-Mental State Examination (MMSE) was performed. In addition, blood for biological variables was collected.

The study was financed by the National Institute on Aging (NIA).

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