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Follow-up of the entire Danish 1905-cohort

The Danish 1905-Cohort Study set out in 1998 to study all Danes born in 1905 who were invited to participate in a home-based, two hour, multidimensional interview, including cognitive and physical performance tests and the collection of DNA. The interview was carried out by lay interviewers using virtually the same instrument as in the Longitudinal Study of Aging Danish Twins (LSADT).

A total of 2262 individuals participated in the first wave in 1998, corresponding to a 63% participation rate. (Nybo et al., 2001a). Although the 63% participation rate in the Danish 1905-Cohort Study is lower than in LSADT, a comparison of non-responders and responders using registry information on hospitalizations and demographics indicates that the sample of participants was fairly representative. The follow-up survey in year 2000 of the Danish 1905-Cohort included a total of 1086 individuals corresponding to a 78% participation rate among the survivors.

The questionnaire includes questions on self-rated health, diseases, medicine, Activities of Daily Living (ADLs), cognitive abilities, depression, and life circumstances and events. Physical tests were included: grip strength, agility, speed, and spirometri. DNA samples were obtained through blood spots or cheek swabs. (For details see: Christensen K. Biological Material in Household Surveys. The Interface between Epidemiology and Genetics. In National Research Council "Cells and Surveys. Should Biological Measures Be Included in Social Science Research?" Committee on Population; Finch CE, Vaupel JW and Kinsella K (eds.). Commission on Behavioral and Social Sciences and Education. Washington DC, National Academy Press 2000: 42-63.

NIH/NIA project: First wave in 1998, follow-up in 2000, 2003, and 2005.

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