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Twin data available

Twin data which are available for scientific purposes:

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Twin survey data

1994 : Omnibus 1
First Omnibus was launched as an umbrella project for a number of health projects to illustrate the relative importance of heredity and environment for the development of common diseases and health conditions in young twins. The study involved 29,344 twins born from 1953-1982. The project grew out of requests from a number of researchers who had an interest in using the then newly established cohort of twins born in this period. A common questionnaire was developed on the basis of the researchers involved, and the answers were used for screening purposes in order to identify specific study populations for follow-up studies.

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1995 - 2007 : LSADT – The Longitudinal Study of Aging in Danish Twins
The study is a population-based twin study initiated to investigate the relative influence of genetic and environmental factors on the health of the elderly in four major domains of human functioning: 1) physical ability and disability, 2) cognitive functioning, 3) depression symptomatology, and 4) health and mortality. All 3,099 Danish twins aged 75 years and older, alive in January 1995 and residing in Denmark were selected for participation in the study. Among all eligible individuals, 2,401 (71%) participated in the baseline examination. Additionally 6 follow-up cohorts were included every second year up to and including 2007. Twins aged 73-76 years were enrolled in the 1997 survey and twins aged 70+ years at the beginning of 1999 and 2001 were enrolled in the respective follow-ups. A total of 4,731 subjects completed the baseline assessment.

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1998 : MADT – The Middle Aged Danish Twins Study
A population-based twin study that was undertaken to examine the relative importance of genetic and environmental factors on health as well as to characterize survival patterns in old age within 4 broad areas: 1) physical ability and disability, 2) cognitive function, 3) depression symptomatology, and 4) health and mortality. The study is a parallel to the LSADT, but includes age groups of twins born in the period 1931-1952. The participants were selected through a stratified sampling involving 240 twins from each birth year from 1931 to 1952. In each birth cohort equal numbers of men and women were selected, distributed among 40 pairs of MZ, 40 pairs of same sex DZ and 40 pairs of DZ twin pairs. A total of 4,314 twins completed a personal interview by means of a structured questionnaire, and biological material was collected.

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1998 + 2009/12 : Geminakar Study
The overall aim of the study is to elucidate the relative importance of genetic and environmental (shared and individual) factors for variation in a number of quantitative biological traits, including clinical chemistry variables related to insulin resistance syndrome, abdominal obesity and associated cardiovascular risk factors. The project includes healthy twin pairs, selected from the DTR and without known diabetes or cardiovascular disease. They resided within an hour’s drive from either Odense or Copenhagen. At baseline, all twins participated in a day-long study program completing a series of questionnaires. The study included 1,512 twins born 1933-1982. This cohort was followed up during 2010-2012 with 1,119 participants. Biological material is stored from both baseline and follow-up.

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2002 : Omnibus 2

Second Omnibus was a large questionnaire-based survey where the questionnaires were mailed to twins born 1931-1982. Again, the project was launched as an umbrella project for a number of health projects to illustrate the relative importance of heredity and environment for the development of common diseases and health conditions in young twins. The study included ??? twins. A standardized questionnaire was developed by the researchers involved, and the answers were used for screening purposes in order to identify specific study populations for follow-up studies.

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2003 : Young Twins
Third Omnibus was a large questionnaire-based survey where the questionnaires were mailed to young twins born 1983-2000. An umbrella project for several smaller sub-projects focused on major common, prevalent diseases. The goal of the research was to study twins’ health and known risk factors and additionally to use this information to determine whether heredity or environment is most important for health and disease.

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2008 - 2011 : DaTRIS – The Danish Twin Registry Infrastructure Study
An umbrella project for a number of subprojects carried out in 2008-2011 comprising twins born 1931-1969. The project included a follow-up on the MADT 98 twins and the non-MADT twins whom we were not able to include in 1998. All together, the DaTRIS comprised the assessment and sampling of biological material of 12,155 MZ and DZ twins.

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2009 + 2012 : Twins Views and Values Study
A follow-up study of twins born 1970-1989. A web-based questionnaire survey. First wave was conducted in 2009 and 3,686 twins participated in this wave. The second follow-up wave was conducted in 2012 and 2,459 twins participated in this wave. The study focused on the impact of family situation, values, approaches and beliefs on adult basic positions and health.

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National register data available

When your project has been approved by the authority responsible for the registries, namely The Danish Data Protection Agency (The SSI Research & Development), it is possible to also apply for data from the following registers:

  • The Danish National Patient Register
  • The Danish Psychiatric Central Research Register
  • The Danish Medical Birth Register
  • The Danish Cancer Registry
  • The Danish Register of Causes of Death
  • The Danish Civil Registration System

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DTR Biological Samples

1997 : LSADT – The Longitudinal Study of Aging in Danish Twins

  • Blood spots (DBS) for DNA
  • Plasma

2001 : LSADT – The Longitudinal Study of Aging in Danish Twins

  • Blood spots (DBS) e.g. DNA

2003 : LSADT – The Longitudinal Study of Aging in Danish Twins

  • Blood spots (DBS) e.g. DNA
  • Hair

2005 : LSADT – The Longitudinal Study of Aging in Danish Twins

  • Blood spots (DBS) e.g.  DNA
  • Cheek Swabs e.g. for DNA

2007 : LSADT – The Longitudinal Study of Aging in Danish Twins

  • Blood/Cells, e.g. for DNA
  • CPT Lymphocytes
  • PaxGene for RNA
  • Plasma

1998 : MADT – The Middle Aged Danish Twins Study

  • Blood spots (DBS) e.g. for DNA
  • Cheek Swabs e.g. for DNA

2008-2011 : MADT – The Middle Aged Danish Twins Study

  • Buffy Coat, e.g. for DNA
  • OraGene saliva – e.g. for DNA
  • PaxGene for RNA
  • Plasma
  • Serum

1998 : Geminakar Study

  • Blood/cells for e.g. DNA

2009-2012 : Geminakar Study

  • Buffy Coat for e.g. DNA
  • Plasma
  • Serum

2008 - 2011 : DaTRIS – The Danish Twin Registry Infrastructure Study

  • Buffy Coat for e.g. DNA
  • Plasma
  • Serum
  • PaxGene for RNA
  • Urine

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