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Research publications

Differentially Methylated Genomic Regions in Birth-Weight Discordant Twin Pairs.
Chen M, Baumbach J, Vandin F, Röttger R, Barbosa E, Dong M, Frost M, Christiansen L, Tan Q.
Ann Hum Genet. 2016 Mar;80(2):81-7. Pubmed abstract 

DNA methylation age is associated with mortality in a longitudinal Danish twin study.
Christiansen L, Lenart A, Tan Q, Vaupel JW, Aviv A, McGue M, Christensen K.
Aging Cell. 2016 Feb;15(1):149-54. Pubmed abstract

Trends in tumors in the central nervous system in elderly in Denmark, 2008-2012.
Dahlrot RH, Poulsen FR, Nguyen NN, Kristensen BW, Hansen S, Holm NV; Academy of Geriatric Cancer Research (AgeCare).
Acta Oncol. 2016 Jan;55 Suppl 1:91-7. Pubmed abstract

Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins.
Dokkedal U, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Anesthesiology. 2016 Feb;124(2):312-21. Pubmed abstract

The Liability Threshold Model for Censored Twin Data.
Holst KK, Scheike TH, Hjelmborg JB.
Computational Statistics & Data Analysis 2016 Jan;93(C):324-35. Open assess

Differences in religiousness in opposite-sex and same-sex twins in a secular society.
Juel Ahrenfeldt L, Lindahl-Jacobsen R, Möller S, Christensen K, Hvidtjørn D, Hvidt NC.
Twin Res Hum Genet. 2016 Feb;19(1):35-46.  Pubmed abstract

A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons.
Kläning U, Trumbetta SL, Gottesman II, Skytthe A, Kyvik KO, Bertelsen A.
Behav Genet. 2016 Mar;46(2):193-204. Pubmed abstract

Genetic and Environmental Regulation on Longitudinal Change of Metabolic Phenotypes in Danish and Chinese Adult Twins.
Li S, Kyvik KO, Pang Z, Zhang D, Duan H, Tan Q, Hjelmborg J, Kruse T, Dalgård C.
PLoS One. 2016 Feb;11(2):e0148396. Pubmed abstract

Smoking and risk for psoriasis: a population-based twin study.
Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF.
Int J Dermatol. 2016 Feb;55(2):e72-8. Pubmed abstract

Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study.
Lønnberg AS, Skov L, Duffy DL, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF.
Acta Derm Venereol. 2016 Jan 20;96(1):35-8.  Pubmed abstract

A Twin Study of Perthes Disease.
Metcalfe D, Van Dijck S, Parsons N, Christensen K, Perry DC.
Pediatrics. 2016 Mar;137(3):1-5. Pubmed abstract

Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration.
JAMA. 2016 Jan 5;315(1):68-76. Pubmed abstract

The Heritability of Breast Cancer among women in the Nordic Twin Study of Cancer.
Möller S, Mucci LA, Harris JR, Scheike T, Holst K, Halekoh U, Adami HO, Czene K, Christensen K, Holm NV, Pukkala E, Skytthe A, Kaprio J, Hjelmborg JB.
Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):145-50. Pubmed abstract

Epilepsy After Febrile Seizures: Twins Suggest Genetic Influence.
Seinfeld SA, Pellock JM, Kjeldsen MJ, Nakken KO, Corey LA.
Pediatr Neurol. 2016 Feb;55:14-6. Pubmed asbtract

Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins.
Skousgaard SG, Skytthe A, Möller S, Overgaard S, Brandt LP.
Arthritis Res Ther. 2016 Feb 11;18(1):46. Pubmed abstract

 

2015

Perceived age is associated with bone status in women aged 25-93 years.
Nielsen BR, Linneberg A, Christensen K, Schwarz P.
Age (Dordr). 2015 Dec;37(6):106. Pubmed abstract

Hyperthyroidism is associated with work disability and loss of labour market income. A Danish register-based study in singletons and disease-discordant twin pairs.
Brandt F, Thvilum M, Hegedüs L, Brix TH.
Eur J Endocrinol. 2015 Nov;173(5):595-602. Pubmed abstract

Stoppage in Autism Spectrum Disorders.
Grønborg TK, Hansen SN, Nielsen SV, Skytthe A, Parner ET.
J Autism Dev Disord. 2015 Nov;45(11):3509-19. Pubmed abstract

Probability and heritability estimates on primary osteoarthritis of the hip leading to total hip arthroplasty: a nationwide population based follow-up study in Danish twins.
Skousgaard SG, Hjelmborg J, Skytthe A, Brandt LP, Möller S, Overgaard S.
Arthritis Res Ther. 2015 Nov 20;17(1):336. Pubmed abstract

Risk of sex-specific cancers in opposite-sex and same-sex twins in Denmark and Sweden.
Ahrenfeldt LJ, Skytthe A, Möller S, Czene K, Adami HO, Mucci LA, Kaprio J, Petersen I, Christensen K, Lindahl-Jacobsen R.
Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1622-8. Pubmed abstract

Heritability of telomere length in a study of long-lived families.
Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N.
Neurobiol Aging. 2015 Oct;36(10):2785-90. Pubmed abstract

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
Jelenkovic A, Christensen K, Skytthe A, Kyvik KO, Tan Q, McGue M et al.
Twin Res Hum Genet. 2015 Oct;18(5):557-70. Pubmed abstract

The APP A673T frequency differs between Nordic countries.
Mengel-From J, Jeune B, Pentti T, McGue M, Christensen K, Christiansen L.
Neurobiol Aging. 2015 Oct;36(10):2909.e1-4. Pubmed abstract

Mitochondrial DNA Copy Number in Sleep Duration Discordant Monozygotic Twins.
Wrede JE, Mengel-From J, Buchwald D, Vitiello MV, Bamshad M, Noonan C, Christiansen L, Christensen K, Watson NF.
Sleep. 2015 Oct 1;38(10):1655-8. Pubmed abstract

Tremor in the elderly: Essential and aging-related tremor.
Deuschl G, Petersen I, Lorenz D, Christensen K.
Mov Disord. 2015 Sep;30(10):1327-34. Pubmed abstract

The heritability of blood donation: a population-based nationwide twin study.
Pedersen OB, Skytthe A, Rostgaard K, Erikstrup C, Edgren G, Nielsen KR, Ullum H, Kyvik KO, Hjalgrim H.
Transfusion. 2015 Sep;55(9):2169-74. Pubmed abstract

Estimating Twin Pair Concordance for Age of Onset.
Scheike TH, Hjelmborg JB, Holst KK.
Behav Genet. 2015 Sep;45(5):573-80. Pubmed abstract

Paternal age and telomere length in twins: the germ stem cell selection paradigm.
Hjelmborg JB, Dalgård C, Mangino M, Spector TD, Halekoh U, Möller S, Kimura M, Horvath K, Kark JD, Christensen K, Kyvik KO, Aviv A.
Aging Cell. 2015 Aug;14(4):701-3. Pubmed abstract

Comorbidity between chronic obstructive pulmonary disease and type 2 diabetes: A nation-wide cohort twin study.
Meteran H, Backer V, Kyvik KO, Skytthe A, Thomsen SF.
Respir Med. 2015 Aug;109(8):1026-30. Pubmed abstract

The CODA Twins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.
Silventoinen K, Christensen K, Skytthe A, Kyvik KO, Tan Q, McGue M et al.
Twin Res Hum Genet. 2015 Aug;18(4):348-60. Pubmed abstract

Staphylococcus aureus and the ecology of the nasal microbiome
Liu CM, Price LB, Hungate BA, Abraham AG, Larsen LS, Christensen K, Stegger M, Skov R, Andersen PS.
Science Advances. 2015 Jun;1(5):e1400216. Online version

Asthma in patients with psoriasis.
Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Meteran H, Backer V, Thomsen SF.
Br J Dermatol. 2015 Jun;172(6):1660-1. Pubmed abstract

Association between leukocyte telomere length and bone mineral density in women 25-93years of age.
Nielsen BR, Linneberg A, Bendix L, Harboe M, Christensen K, Schwarz P.
Exp Gerontol. 2015 Jun;66:25-31. Pubmed abstract

The heritability of prostate cancer-response.
Hjelmborg JB.
Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):879.

The heritability of leucocyte telomere length dynamics.
Hjelmborg JB, Dalgård C, Möller S, Steenstrup T, Kimura M, Christensen K, Kyvik KO, Aviv A.
J Med Genet. 2015 May;52(5):297-302. Pubmed abstract

A twin study of the trough plasma steady-state concentration of metformin.
Stage TB, Damkier P, Pedersen RS, Christensen MM, Christiansen L, Christensen K, Brosen K.
Pharmacogenet Genomics. 2015 May;25(5):259-62. Pubmed abstract

Physical and mental decline and yet rather happy? A study of Danes aged 45 and older.
Vestergaard S, Thinggaard M, Jeune B, Vaupel JW, McGue M, Christensen K.
Aging Ment Health. 2015 May;19(5):400-8. Pubmed abstract

Gene, environment and cognitive function: a Chinese twin ageing study.
Xu C, Sun J, Duan H, Ji F, Tian X, Zhai Y, Wang S, Pang Z, Zhang D, Zhao Z, Li S, Gue MM, Hjelmborg JV, Christensen K, Tan Q.
Age Ageing. 2015 May;44(3):452-7. Pubmed abstract

Measuring early or late dependence for bivariate lifetimes of twins.
Scheike TH, Holst KK, Hjelmborg JB.
Lifetime Data Anal. 2015 Apr;21(2):280-99. Pubmed abstract

Academic performance of opposite-sex and same-sex twins in adolescence: A Danish national cohort study.
Juel Ahrenfeldt L, Petersen I, Johnson W, Christensen K.
Horm Behav. 2015 Mar;69C:123-131. Pubmed abstract

DCAF4, a novel gene associated with leucocyte telomere length.
Mangino M, Christiansen L, Stone R, Hunt SC, Horvath K, Eisenberg DT, Kimura M, Petersen I, Kark JD, Herbig U, Reiner AP, Benetos A, Codd V, Nyholt DR, Sinnreich R, Christensen K, Nassar H, Hwang SJ, Levy D, Bataille V, Fitzpatrick AL, Chen W, Berenson GS, Samani NJ, Martin NG, Tishkoff S, Schork NJ, Kyvik KO, Dalgård C, Spector TD, Aviv A.
J Med Genet. 2015 Mar;52(3):157-62. Pubmed abstract

Genetic and environmental influences in Dupuytren's disease: A study of 30,330 Danish twin pairs.
Larsen S, Krogsgaard DG, Larsen LA, Iachina M, Skytthe A, Frederiksen H.
J Hand Surg Eur Vol. 2015 Feb;40(2):171-6. Pubmed abstract

The genetic basis for cognitive ability, memory, and depression symptomatology in middle-aged and elderly Chinese twins.
Xu C, Sun J, Ji F, Tian X, Duan H, Zhai Y, Wang S, Pang Z, Zhang D, Zhao Z, Li S, Hjelmborg JV, Christensen K, Tan Q.
Twin Res Hum Genet. 2015 Feb;18(1):79-85. Pubmed abstract

Multivariate modelling of body mass index, pulse pressure, systolic and diastolic blood pressure in Chinese twins.
Wu Y, Zhang D, Pang Z, Jiang W, Wang S, Li S, von Bornemann Hjelmborg J, Tan Q.
Twin Res Hum Genet. 2015 Feb;18(1):73-8. Pubmed abstract

The liability threshold model for censored twin data.
Holst KK, Scheike TH, Hejlmborg JB.
Computational Statistics & Data Analysis. 2015 Jan. Abstract

Genetic and environmental transactions underlying the association between physical fitness/physical exercise and body composition.
Johnson W, de Ruiter I, Kyvik KO, Murray AL, Sørensen TI.
Behav Genet. 2015 Jan;45(1):84-105. Pubmed abstract

Gene-environment interaction in atopic diseases: a population-based twin study of early-life exposures.
Kahr N, Naeser V, Stensballe LG, Kyvik KO, Skytthe A, Backer V, Bønnelykke K, Thomsen SF.
Clin Respir J. 2015 Jan;9(1):79-86. Pubmed abstract

Twin methodology in epigenetic studies.
Tan Q, Christiansen L, von Bornemann Hjelmborg J, Christensen K.
J Exp Biol. 2015 Jan 1;218(Pt 1):134-9. Review. Pubmed abstract

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