Research publications

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins.

Mengel-From J, Rønne ME, Carlsen AL, Skogstrand K, Larsen LA, Tan Q, Christiansen L, Christensen K, Heegaard NHH.

J Alzheimers Dis. 2018 Apr;63(2):591-601. Pubmed abstract 

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register.
Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, Nordentoft M, Glenthøj B.
Biol Psychiatry. 2018 Mar;83(6):492-498. Pubmed abstract

No impact of surgery on cognitive function: a longitudinal study of middle-aged Danish twins.
Dokkedal U, Wod M, Thinggaard M, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Ann Epidemiol. 2018 Feb;28(2):95-101.  Pubmed abstract

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB.
Genes (Basel). 2018 Feb;9(2). Pubmed abstract

Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.
Ulff-Møller CJ, Svendsen AJ, Viemose LN, Jacobsen S.
Semin Arthritis Rheum. 2018 Feb;47(4):538-544. Pubmed abstract

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study.
Xu C, Tian X, Sun J, Wu Y, Zhang D, Pang Z, Li S, Petersen I, Mengel-From J, Christiansen L, Christensen K, Tan Q.
Geriatr Gerontol Int. 2018 Feb;18(2):352-359.7. Pubmed abstract

DNA methylation age and perceived age in elderly Danish twins.
Debrabant B, Soerensen M, Christiansen L, Tan Q, McGue M, Christensen K, Hjelmborg J.
Mech Ageing Dev. 2018 Jan;169:40-44. Pubmed abstract

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB.
Heart 2018 Jan;104(1):30-36. Pubmed abstract


Lung function discordance in monozygotic twins and associated differences in blood DNA methylation.
Bolund ACS, Starnawska A, Miller MR, Schlünssen V, Backer V, Børglum AD, Christensen K, Tan Q, Christiansen L, Sigsgaard T.
Clin Epigenetics. 2017 Dec;9:132. eCollection 2017. Pubmed abstract

Heritability of the Number of Teeth in Middle-Aged and Older Danish Twins.
Kurushima Y, Silventoinen K, Dokkedal U, Skytthe A, Mucci LA, Christensen K, Hjelmborg JVB.
J Dent Res. 2017 Dec;96(13):1513-1517 Pubmed abstract


Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins.
Osler M, Christensen GT, Garde E, Mortensen EL, Christensen K.
Alzheimers Dement. 2017 Dec;13(12):1355-1363. Pubmed abstract


Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins.
Starnawska A, Tan Q, McGue M, Mors O, Børglum AD, Christensen K, Nyegaard M, Christiansen L.
Front Aging Neurosci. 2017 Dec;9:413. eCollection 2017. Pubmed abstract

Lung cancer, genetic predisposition and smoking: the Nordic Twin Study of Cancer.

Hjelmborg JB, Korhonen T, Holst K, Skytthe A, Pukkala E, Kutschke J, Harris JR, Mucci LA, Christensen K, Czene K, Adami HO, Scheike T, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) collaboration.
Thorax. 2017 Nov;72(11):1021-1027. Pubmed abstract


Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI.
Wang W, Jiang W, Hou L, Duan H, Wu Y, Xu C, Tan Q, Li S, Zhang D.
BMC Genomics. 2017 Nov;18(1):872. Pubmed abstract


Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
Silventoinen K, Tan Q, McGue M, Kaprio J et al.
Twin Res Hum Genet. 2017 Oct;20(5):395-405. Pubmed abstract


Genetic and Environmental Influences on Correlations Between Hearing and Cognitive Functions in Middle and Older Chinese Twins.
Xu C, Zhang D, Tian X, Duan H, Wu Y, Pang Z, Li S, Tan Q.
Twin Res Hum Genet. 2017 Oct;20(5):374-379. Pubmed abstract


A genome-wide association study of cognitive function in Chinese adult twins.
Xu C, Zhang D, Wu Y, Tian X, Pang Z, Li S, Tan Q.
Biogerontology. 2017 Oct;18(5):811-819. Pubmed abstract

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.
Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, Hjelmborg JV, Szczepek AJ, Canlon B, Mazurek B, Lopez-Escamez JA, Cederroth CR.
Genet Med. 2017 Sep;19(9):1007-1012. Pubmed abstract

Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer.
Graff RE, Möller S, Passarelli MN, Witte JS, Skytthe A, Christensen K, Tan Q, Adami HO, Czene K, Harris JR, Pukkala E, Kaprio J, Giovannucci E, Mucci LA, Hjelmborg JB.
Clin Gastroenterol Hepatol. 2017 Aug;15(8):1256-1264. Pubmed abstract

Risk aversion and religious behaviour: Analysis using a sample of Danish twins.
Nielsen JS, Bech M, Christensen K, Kiil A, Hvidt NC.
Econ Hum Biol. 2017 Aug;26:21-29. Pubmed abstract

Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts.
Silventoinen K, Hjelmborg J, Möller S, Ripatti S, Skytthe A, Tikkanen E, Pedersen NL, Magnusson PKE, Christensen K, Kaprio J.
Int J Epidemiol. 2017 Aug 1;46(4):1223-1229. Pubmed abstract

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.
Silventoinen K, Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Cozen W, Hwang AE, Mack TM, Honda C, Inui F, Iwatani Y, Watanabe M, Tomizawa R, Pietiläinen KH, Rissanen A, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Piirtola M, Aaltonen S, Öncel SY, Aliev F, Rebato E, Hjelmborg JB, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Cutler TL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Song YM, Yang S, Lee K, Franz CE, Kremen WS, Lyons MJ, Busjahn A, Nelson TL, Whitfield KE, Kandler C, Jang KL, Gatz M, Butler DA, Stazi MA, Fagnani C, D'Ippolito C, Duncan GE, Buchwald D, Martin NG, Medland SE, Montgomery GW, Jeong HU, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Dahl Aslan AK, McAdams TA, Eley TC, Gregory AM, Tynelius P, Baker LA, Tuvblad C, Bayasgalan G, Narandalai D, Spector TD, Mangino M, Lachance G, Burt SA, Klump KL, Harris JR, Brandt I, Nilsen TS, Krueger RF, McGue M, Pahlen S, Corley RP, Huibregtse BM, Bartels M, van Beijsterveldt CE, Willemsen G, Goldberg JH, Rasmussen F, Tarnoki AD, Tarnoki DL, Derom CA, Vlietinck RF, Loos RJ, Hopper JL, Sung J, Maes HH, Turkheimer E, Boomsma DI, Sørensen TI, Kaprio J.
Am J Clin Nutr. 2017 Aug;106(2):457-466. Pubmed abstract

The oldest-old in China - Authors' reply.
Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW.
Lancet. 2017 Aug 26;390(10097):847.

Twin-singleton early-life survival in sub-Saharan Africa.
Christensen K, Bjerregaard-Andersen M.
Lancet Glob Health. 2017 Jul;5(7):e636-e637. Pubmed abstract

Epigenetic Consequences of Low Birth-Weight and Preterm Birth in Adult Twins.
Qihua Tan.
In: Handbook of Nutrition, Diet, and Epigenetics. Springer Reference LIVE. Jul 2017. pp 1-13.

Chromosomal aberrations in monozygotic and dizygotic twins born in Denmark during 1968-2009.
Kroeldrup L, Larsen LA, Fagerberg C, Hertz JM, Christensen K.
Twin Res Hum Genet. 2017 Jun;20(3):216-225.  Pubmed abstract

Comparison of Late Mortality among Twins versus Singletons with Congenital Heart Defects.
Herskind AM, Larsen LA, Pedersen DA,  Christensen K.
Am J Cardiol. 2017 May 15;119(10):1680-1686. Pubmed abstract

Early-life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis.
Ahrenfeldt LJ, Larsen LA, Lindahl-Jacobsen R, Skytthe A, Hjelmborg JV, Möller S, Christensen K.
Ann Epidemiol. 2017 Feb;27(2):115-120.e2. Pubmed abstract

Faith Moves Mountains-Mountains Move Faith: Two Opposite Epidemiological Forces in Research on Religion and Health.
Hvidt NC, Hvidtjørn D, Christensen K, Nielsen JB, Søndergaard J.
J Relig Health. 2017 Feb;56(1):294-304. Pubmed abstract

Genetic and Environmental Influences on Pulmonary Function and Muscle Strength: The Chinese Twin Study of Aging.
Tian X, Xu C, Wu Y, Sun J, Duan H, Zhang D, Jiang B, Pang Z, Li S, Tan Q.
Twin Res Hum Genet. 2017 Feb;20(1):53-59. Pubmed abstract

Genetic and Environmental Basis in Phenotype Correlation Between Physical Function and Cognition in Aging Chinese Twins.
Xu C, Zhang D, Tian X, Wu Y, Pang Z, Li S, Tan Q.
Twin Res Hum Genet. 2017 Feb;20(1):60-65. Pubmed abstract

The influence of familial factors on the intelligence-mortality association: A twin approach.
Christensen GT, Osler M, Madsen M, McGue M, Mortensen EL, Christensen K.
Intelligence. 2017;64:60-66.

Exploring Subclinical Phenotypic Features in Twin Pairs Discordant for Cleft Lip and Palate.

Leslie EJ, Carlson JC, Cooper ME, Christensen K, Weinberg SM, Marazita ML.
Cleft Palate Craniofac J. 2017 Jan;54(1):90-93. Pubmed abstract

Investigating heredity in cutaneous T-cell lymphoma in a unique cohort of Danish twins.
Odum N, Lindahl L, Wod M, Krejsgaard T, Skytthe A, Woetmann A, Iversen L, Christensen K.
Blood Cancer Journal 2017 Jan;7(1):e517. 

Disease-Concordant Twins Empower Genetic Association Studies.
Tan Q, Li W, Vandin F.
Ann Hum Genet. 2017 Jan;81(1):20-26. Pubmed abstract

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