Research publications

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.

EBioMedicine. 2019. [Epub ahead of print] Pubmed abstract

Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study.

Meluken I, Ottesen NM, Harmer CJ, Scheike T, Kessing LV, Vinberg M, Miskowiak KW.

Psychol Med. 2018. [Epub ahead of print] Pubmed abstract


Is who you ask important? Concordance between survey and registry data on medication use among self- and proxy-respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study.
Oksuzyan A, Sauer T, Gampe J, Höhn A, Wod M, Christensen K, Wastesson JW.
J Gerontol A Biol Sci Med Sci. 2018.  Pubmed abstract [Epub ahead of print].

A major limitation of the direction of causation model: non-shared environmental confounding.

Rasmussen SHR, Ludeke S, Hjelmborg JVB.

Twin Res Hum Genet. 2019. [Epub ahead of print] Pubmed abstract


Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a 1[H]-spectroscopy twin study.

Legind CS, Broberg BV, Mandl RCW, Brouwer R, Anhøj SJ, Hilker R, Jensen MH, McGuire P, Pol HH, Fagerlund B, Rostrup E, Glenthøj BY.

Neuropsychopharmacology. 2019 Feb;44(3):581-589. Pubmed abstract



Self-reported intake of fruit and vegetables and risk of chronic obstructive pulmonary disease: A nation-wide twin study.

Meteran H, Thomsen SF, Miller MR, Hjelmborg J, Sigsgaard T, Backer V.

Respir Med. 2018 Nov;144:16-21. Pubmed abstract


Family occurrence of autoimmune hepatitis: A Danish nationwide registry-based cohort study.

Grønbæk L, Vilstrup H, Pedersen L, Christensen K, Jepsen P.

J Hepatol. 2018 Oct;69(4):873-877. Pubmed abstract


Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.
Mengel-From J, Feddersen S, Halekoh U, Heegaard NHH, McGue M, Christensen K, Tan Q, Christiansen L.
Eur J Hum Genet. 2018 Sep;
26(9):1378-1387. Pubmed abstract

Irving I. Gottesman's Collaboration in Psychiatric. Genetics Research in Denmark.
Christensen K, Bertelsen A.
Twin Res Hum Genet. 2018 Aug;21(4):322-323. Pubmed abstract

Clinical Characteristics, Life Adversities and Personality Traits in Monozygotic Twins With, at Risk of and Without Affective Disorders.

Ottesen NM, Meluken I, Scheike T, Kessing LV, Miskowiak KW, Vinberg M.

Front Psychiatry. 2018 Aug;9:401. Pubmed abstract


Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Savage JE, Nygaard M, Christiansen L, Debrabant B et al.
Nat Genet. 2018 Jul;50(7):912-919. Pubmed abstract


Risk of epilepsy in opposite-sex and same-sex twins: a twin cohort study.
Mao Y, Ahrenfeldt LJ, Christensen K, Wu C, Christensen J, Olsen J, Sun Y.
Biol Sex Differ. 2018 Jun;9(1):21. Pubmed abstract

Epigenetic signature of preterm birth in adult twins.
Tan Q, Li S, Frost M, Nygaard M, Soerensen M, Larsen M, Christensen K, Christiansen L.
Clin Epigenetics. 2018 Jun;10:87. Pubmed abstract

Myeloproliferative Neoplasms in Danish Twins.
Andersen MA, Bjerrum OW, Ranjan A, Skov V, Kruse TA, Thomassen M, Skytthe A, Hasselbalch HC, Christensen K.
Acta Haematol. 2018 May;139(3):195-198. Pubmed abstract

Age-Moderation of Genetic and Environmental Contributions to Cognitive Functioning in Mid- and Late-Life for Specific Cognitive Abilities.

Pahlen S, Hamdi NR, Dahl Aslan AK, Horwitz BN, Panizzon MS, Petersen I, Zavala C, Christensen K, Finkel D, Franz CE, Gatz M, Johnson W, Kremen WS, Krueger RF, Neiderhiser JM, Reynolds CA, Pedersen NL, McGue M.

Intelligence. 2018 May;68:70-81. Pubmed abstract


The relationship between subjective well-being and mortality within discordant twin pairs from two independent samples.
Saunders GRB, Elkins IJ, Christensen K, McGue M.
Psychol Aging. 2018 May;33(3):439-447. Pubmed abstract

Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline.
Wod M, Hallas J, Andersen K, García Rodríguez LA, Christensen K, Gaist D.
Clin Gastroenterol Hepatol. 2018 May;16(5):681-689. Pubmed abstract

Resting Heart Rate Is Not Associated with Cognitive Function.

Wod M, Jensen MT, Galatius S, Hjelmborg JB, Jensen GB, Christensen K.

Neuroepidemiology. 2018 May;50(3-4):160-167. Pubmed abstract


Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins.

Mengel-From J, Rønne ME, Carlsen AL, Skogstrand K, Larsen LA, Tan Q, Christiansen L, Christensen K, Heegaard NHH.

J Alzheimers Dis. 2018 Apr;63(2):591-601. Pubmed abstract


Migraine with visual aura associated with thicker visual cortex.

Gaist D, Hougaard A, Garde E, Reislev NL, Wiwie R, Iversen P, Madsen CG, Blaabjerg M, Nielsen HH, Krøigård T, Østergaard K, Kyvik KO, Hjelmborg J, Madsen K, Siebner HR, Ashina M.

Brain. 2018 Mar;141(3):776-785. Pubmed abstract


Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register.

Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, Nordentoft M, Glenthøj B.
Biol Psychiatry. 2018 Mar;83(6):492-498. Pubmed abstract

No impact of surgery on cognitive function: a longitudinal study of middle-aged Danish twins.
Dokkedal U, Wod M, Thinggaard M, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Ann Epidemiol. 2018 Feb;28(2):95-101.  Pubmed abstract

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB.
Genes (Basel). 2018 Feb;9(2). Pubmed abstract

Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.
Ulff-Møller CJ, Svendsen AJ, Viemose LN, Jacobsen S.
Semin Arthritis Rheum. 2018 Feb;47(4):538-544. Pubmed abstract

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study.
Xu C, Tian X, Sun J, Wu Y, Zhang D, Pang Z, Li S, Petersen I, Mengel-From J, Christiansen L, Christensen K, Tan Q.
Geriatr Gerontol Int. 2018 Feb;18(2):352-359.7. Pubmed abstract

DNA methylation age and perceived age in elderly Danish twins.
Debrabant B, Soerensen M, Christiansen L, Tan Q, McGue M, Christensen K, Hjelmborg J.
Mech Ageing Dev. 2018 Jan;169:40-44. Pubmed abstract

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB.
Heart. 2018 Jan;104(1):30-36. Pubmed abstract

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