Research publications

The Danish Twin Registry: An Updated Overview

Pedersen DA, Larsen LA, Nygaard M, Mengel-From J, McGue M, Dalgård C, Hvidberg L, Hjelmborg J, Skytthe A, Holm NV, Kyvik KO, Christensen K.

Twin Res Hum Genet. 2019 Dec;22(6):499-507. Pubmed abstract

A genome-wide integrative association study of DNA methylation and gene expression data and later life cognitive functioning in monozygotic twins.
Soerensen M, Hozakowska-Roszkowska DM, Nygaard M, Larsen MJ, Schwämmle V, Christensen K, Christiansen L, Tan Q. 
Frontiers in Neuroscience. 2020. (Accepteret/In press)


Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits.

Ahrenfeldt LJ, Christensen K, Segal NL, Hur YM.

Neurosci Biobehav Rev. 2020 Jan;108:322-340. Pubmed abstract


Clonal hematopoiesis in elderly twins: concordance, discordance and mortality.
Hansen JB, Pedersen DA, Larsen LA, Husby S, Clemmensen SB, Hjelmborg J, Favero F, Weischenfeldt J, Christensen K, Grønbæk K.
Blood J. 2020 Jan;135 (4): 261–268. Online version



The Nordic Twin Study on Cancer - NorTwinCan.

Harris JR, Hjelmborg J, Adami HO, Czene K, Mucci L, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration.

Twin Res Hum Genet. 2019 Dec;22(6):817-823. Pubmed abstract 


DNA methylome profiling in identical twin pairs discordant for body mass index.

Li W, Zhang D, Wang W, Wu Y, Mohammadnejad A, Lund J, Baumbach J, Christiansen L, Tan Q.

Int J Obes (Lond). 2019 Dec;43(12):2491-2499. Pubmed abstract


IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.

Pedersen NL, Gatz M, Finch BK, Finkel D, Butler DA, Dahl Aslan A, Franz CE, Kaprio J, Lapham S, McGue M, Mosing MA, Neiderhiser J, Nygaard M, Panizzon M, Prescott CA, Reynolds CA, Sachdev P, Whitfield KE.

Twin Res Hum Genet. 2019 Dec;22(6):809-816. Pubmed abstract


Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies.

Mengel-From J, Svane AM, Pertoldi C, Nygaard Kristensen T, Loeschcke V, Skytthe A, Christensen K, Lindahl-Jacobsen R, Hjelmborg J, Christiansen L.

J Gerontol A Biol Sci Med Sci. 2019 Nov;74(12):1853-1860. Pubmed abstract


Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.

Soerensen M, Li W, Debrabant B, Nygaard M, Mengel-From J, Frost M, Christensen K, Christiansen L, Tan Q.
Biogerontology. 2019 Oct;20(5):627-647. Pubmed abstract


Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.

Starnawska A, Tan Q, Soerensen M, McGue M, Mors O, Børglum AD, Christensen K, Nyegaard M, Christiansen L.

Transl Psychiatry. 2019 Sep;9(1):214. Pubmed abstract


The association between depressive mood and ischemic heart disease: a twin study.

Wium-Andersen MK, Wium-Andersen IK, Jørgensen MB, McGue M, Jørgensen TSH, Christensen K, Osler M.

Acta Psychiatr Scand. 2019 Sep;140(3):265-274. Pubmed abstract


The risk of asthma is increased among women with polycystic ovary syndrome: a twin study.
Zierau L, Meteran H, Backer V, Lindenberg S, Skytthe A, Thomsen SF.
ERJ Open Res. 2019 Sep;5(3). Pubmed abstract


Epigenome-wide association study of leukocyte telomere length.

Lee Y, Sun D, Ori APS, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li S, Harris JR, Magnus P, Aviv A, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Aug;11(16):5876-5894.  Pubmed abstract


Global expression profiling of cognitive level and decline in middle-aged monozygotic twins.

Nygaard M, Larsen MJ, Thomassen M, McGue M, Christensen K, Tan Q, Christiansen L.

Neurobiol Aging. 2019 Aug;84:141-147. Pubmed abstract


The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.

Silventoinen K, Hjelmborg JVB, Christensen K, Skytthe A, Kyvik KO, Tan Q, McGue M, Kaprio J. et al

Twin Res Hum Genet. 2019 Jul 31:1-9. Pubmed abstract 


Tupakoinnin vaikutus geneettiseen keuhkosyöpäalttiuteen - tutkimuksen tuloksia Nordic Twin Study of Cancer (NorTwinCan)
Kaprio J, Brandt I, Harris J R,  Hjelmborg JB.
BestPractice Nordic. 2019 Apr.

Enriched power of disease-concordant twin-case-only design in detecting interactions in genome-wide association studies.

Li W, Baumbach J, Mohammadnejad A, Brasch-Andersen C, Vandin F, Korbel JO, Tan Q.

Eur J Hum Genet. 2019 Apr;27(4):631-636. Pubmed abstract


Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study.

Meluken I, Ottesen NM, Harmer CJ, Scheike T, Kessing LV, Vinberg M, Miskowiak KW.

Psychol Med. 2019 Apr;49(6):987-996. Pubmed abstract


Is who you ask important? Concordance between survey and registry data on medication use among self- and proxy-respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study.

Oksuzyan A, Sauer T, Gampe J, Höhn A, Wod M, Christensen K, Wastesson JW.
J Gerontol A Biol Sci Med Sci. 2019 Apr;74(5):742-747.  Pubmed abstract 

Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers.

Skytthe A, Harris JR, Czene K, Mucci L, Adami HO, Christensen K, Hjelmborg J, Holm NV, Nilsen TS, Kaprio J, Pukkala E.

Twin Res Hum Genet. 2019 Apr;22(2):99-107. Pubmed abstract


Lifespans of Twins: Does Zygosity Matter?

Hjelmborg J, Larsen P, Kaprio J, McGue M, Scheike T, Hougaard P, Christensen K.

Genes (Basel). 2019 Feb 20;10(2). Pubmed abstract


Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.

EBioMedicine. 2019 Feb;40:710-716. Pubmed abstract

Hvordan røyking påvirker den genetiske disposisjonen for lungekreft - resultater fra Nordic Twin Study of Cancer (NorTwinCan)

Kaprio J, Brandt I, Harris J R, Hjelmborg JB.
BestPractice Nordic: Onkologia/Hematologia. 2019 Feb. 

A major limitation of the direction of causation model: non-shared environmental confounding.

Rasmussen SHR, Ludeke S, Hjelmborg JVB.

Twin Res Hum Genet. 2019 Feb;22(1):14-26. Pubmed abstract


White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study.

Svendsen AJ, Tan Q, Jakobsen MA, Thyagarajan B, Nygaard M, Christiansen L, Mengel-From J.

J Autoimmun. 2019 Jan;96:142-146. Pubmed abstract

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