Research publications

The Danish Twin Registry: An Updated Overview

Pedersen DA, Larsen LA, Nygaard M, Mengel-From J, McGue M, Dalgård C, Hvidberg L, Hjelmborg J, Skytthe A, Holm NV, Kyvik KO, Christensen K.

Twin Res Hum Genet. 2019. [Epub ahead of print] Pubmed abstract

DNA methylome profiling in identical twin pairs discordant for body mass index.

Li W, Zhang D, Wang W, Wu Y, Mohammadnejad A, Lund J, Baumbach J, Christiansen L, Tan Q.

Int J Obes (Lond). 2019. Pubmed abstract  [Epub ahead of print]


The risk of asthma is increased among women with polycystic ovary syndrome: a twin study.
Zierau L, Meteran H, Backer V, Lindenberg S, Skytthe A, Thomsen SF.


Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.

Soerensen M, Li W, Debrabant B, Nygaard M, Mengel-From J, Frost M, Christensen K, Christiansen L, Tan Q.
Biogerontology. 2019 Oct;20(5):627-647. Pubmed abstract


Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.

Starnawska A, Tan Q, Soerensen M, McGue M, Mors O, Børglum AD, Christensen K, Nyegaard M, Christiansen L.

Transl Psychiatry. 2019 Sep;9(1):214. Pubmed abstract


The association between depressive mood and ischemic heart disease: a twin study.

Wium-Andersen MK, Wium-Andersen IK, Jørgensen MB, McGue M, Jørgensen TSH, Christensen K, Osler M.

Acta Psychiatr Scand. 2019 Sep;140(3):265-274. Pubmed abstract


Epigenome-wide association study of leukocyte telomere length.

Lee Y, Sun D, Ori APS, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li S, Harris JR, Magnus P, Aviv A, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Aug;11(16):5876-5894.  Pubmed abstract


The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.

Silventoinen K, Hjelmborg JVB, Christensen K, Skytthe A, Kyvik KO, Tan Q, McGue M, Kaprio J. et al

Twin Res Hum Genet. 2019 Jul 31:1-9. Pubmed abstract 


Is who you ask important? Concordance between survey and registry data on medication use among self- and proxy-respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study.

Oksuzyan A, Sauer T, Gampe J, Höhn A, Wod M, Christensen K, Wastesson JW.
J Gerontol A Biol Sci Med Sci. 2019 Apr;74(5):742-747.  Pubmed abstract 

Tupakoinnin vaikutus geneettiseen keuhkosyöpäalttiuteen - tutkimuksen tuloksia Nordic Twin Study of Cancer (NorTwinCan)
Kaprio J, Brandt I, Harris J R,  Hjelmborg JB.
BestPractice Nordic. 2019 Apr.

Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study.

Meluken I, Ottesen NM, Harmer CJ, Scheike T, Kessing LV, Vinberg M, Miskowiak KW.

Psychol Med. 2019 Apr;49(6):987-996. Pubmed abstract


Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers.

Skytthe A, Harris JR, Czene K, Mucci L, Adami HO, Christensen K, Hjelmborg J, Holm NV, Nilsen TS, Kaprio J, Pukkala E.

Twin Res Hum Genet. 2019 Apr;22(2):99-107. Pubmed abstract


Lifespans of Twins: Does Zygosity Matter?

Hjelmborg J, Larsen P, Kaprio J, McGue M, Scheike T, Hougaard P, Christensen K.

Genes (Basel). 2019 Feb 20;10(2). Pubmed abstract


Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.

EBioMedicine. 2019 Feb;40:710-716. Pubmed abstract

Hvordan røyking påvirker den genetiske disposisjonen for lungekreft - resultater fra Nordic Twin Study of Cancer (NorTwinCan)

Kaprio J, Brandt I, Harris J R, Hjelmborg JB.
BestPractice Nordic: Onkologia/Hematologia. 2019 Feb.

Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a 1[H]-spectroscopy twin study.

Legind CS, Broberg BV, Mandl RCW, Brouwer R, Anhøj SJ, Hilker R, Jensen MH, McGuire P, Pol HH, Fagerlund B, Rostrup E, Glenthøj BY.

Neuropsychopharmacology. 2019 Feb;44(3):581-589. Pubmed abstract


A major limitation of the direction of causation model: non-shared environmental confounding.

Rasmussen SHR, Ludeke S, Hjelmborg JVB.

Twin Res Hum Genet. 2019 Feb;22(1):14-26. Pubmed abstract



Self-reported intake of fruit and vegetables and risk of chronic obstructive pulmonary disease: A nation-wide twin study.

Meteran H, Thomsen SF, Miller MR, Hjelmborg J, Sigsgaard T, Backer V.

Respir Med. 2018 Nov;144:16-21. Pubmed abstract


Family occurrence of autoimmune hepatitis: A Danish nationwide registry-based cohort study.

Grønbæk L, Vilstrup H, Pedersen L, Christensen K, Jepsen P.

J Hepatol. 2018 Oct;69(4):873-877. Pubmed abstract


Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.
Mengel-From J, Feddersen S, Halekoh U, Heegaard NHH, McGue M, Christensen K, Tan Q, Christiansen L.
Eur J Hum Genet. 2018 Sep;
26(9):1378-1387. Pubmed abstract

Irving I. Gottesman's Collaboration in Psychiatric. Genetics Research in Denmark.
Christensen K, Bertelsen A.
Twin Res Hum Genet. 2018 Aug;21(4):322-323. Pubmed abstract

Clinical Characteristics, Life Adversities and Personality Traits in Monozygotic Twins With, at Risk of and Without Affective Disorders.

Ottesen NM, Meluken I, Scheike T, Kessing LV, Miskowiak KW, Vinberg M.

Front Psychiatry. 2018 Aug;9:401. Pubmed abstract


Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Savage JE, Nygaard M, Christiansen L, Debrabant B et al.
Nat Genet. 2018 Jul;50(7):912-919. Pubmed abstract


Risk of epilepsy in opposite-sex and same-sex twins: a twin cohort study.
Mao Y, Ahrenfeldt LJ, Christensen K, Wu C, Christensen J, Olsen J, Sun Y.
Biol Sex Differ. 2018 Jun;9(1):21. Pubmed abstract

Epigenetic signature of preterm birth in adult twins.
Tan Q, Li S, Frost M, Nygaard M, Soerensen M, Larsen M, Christensen K, Christiansen L.
Clin Epigenetics. 2018 Jun;10:87. Pubmed abstract

Myeloproliferative Neoplasms in Danish Twins.
Andersen MA, Bjerrum OW, Ranjan A, Skov V, Kruse TA, Thomassen M, Skytthe A, Hasselbalch HC, Christensen K.
Acta Haematol. 2018 May;139(3):195-198. Pubmed abstract

Age-Moderation of Genetic and Environmental Contributions to Cognitive Functioning in Mid- and Late-Life for Specific Cognitive Abilities.

Pahlen S, Hamdi NR, Dahl Aslan AK, Horwitz BN, Panizzon MS, Petersen I, Zavala C, Christensen K, Finkel D, Franz CE, Gatz M, Johnson W, Kremen WS, Krueger RF, Neiderhiser JM, Reynolds CA, Pedersen NL, McGue M.

Intelligence. 2018 May;68:70-81. Pubmed abstract


The relationship between subjective well-being and mortality within discordant twin pairs from two independent samples.
Saunders GRB, Elkins IJ, Christensen K, McGue M.
Psychol Aging. 2018 May;33(3):439-447. Pubmed abstract

Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline.
Wod M, Hallas J, Andersen K, García Rodríguez LA, Christensen K, Gaist D.
Clin Gastroenterol Hepatol. 2018 May;16(5):681-689. Pubmed abstract

Resting Heart Rate Is Not Associated with Cognitive Function.

Wod M, Jensen MT, Galatius S, Hjelmborg JB, Jensen GB, Christensen K.

Neuroepidemiology. 2018 May;50(3-4):160-167. Pubmed abstract


Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins.

Mengel-From J, Rønne ME, Carlsen AL, Skogstrand K, Larsen LA, Tan Q, Christiansen L, Christensen K, Heegaard NHH.

J Alzheimers Dis. 2018 Apr;63(2):591-601. Pubmed abstract


Migraine with visual aura associated with thicker visual cortex.

Gaist D, Hougaard A, Garde E, Reislev NL, Wiwie R, Iversen P, Madsen CG, Blaabjerg M, Nielsen HH, Krøigård T, Østergaard K, Kyvik KO, Hjelmborg J, Madsen K, Siebner HR, Ashina M.

Brain. 2018 Mar;141(3):776-785. Pubmed abstract


Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register.

Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, Nordentoft M, Glenthøj B.
Biol Psychiatry. 2018 Mar;83(6):492-498. Pubmed abstract

No impact of surgery on cognitive function: a longitudinal study of middle-aged Danish twins.
Dokkedal U, Wod M, Thinggaard M, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Ann Epidemiol. 2018 Feb;28(2):95-101.  Pubmed abstract

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB.
Genes (Basel). 2018 Feb;9(2). Pubmed abstract

Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.
Ulff-Møller CJ, Svendsen AJ, Viemose LN, Jacobsen S.
Semin Arthritis Rheum. 2018 Feb;47(4):538-544. Pubmed abstract

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study.
Xu C, Tian X, Sun J, Wu Y, Zhang D, Pang Z, Li S, Petersen I, Mengel-From J, Christiansen L, Christensen K, Tan Q.
Geriatr Gerontol Int. 2018 Feb;18(2):352-359.7. Pubmed abstract

DNA methylation age and perceived age in elderly Danish twins.
Debrabant B, Soerensen M, Christiansen L, Tan Q, McGue M, Christensen K, Hjelmborg J.
Mech Ageing Dev. 2018 Jan;169:40-44. Pubmed abstract

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB.
Heart. 2018 Jan;104(1):30-36. Pubmed abstract

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