COPING AD

COPING AD is a research initiative targeting disease mechanisms in Alzheimer's Disease.

COPING AD was coined in 2013 when it received support from SDU2020, a fund created by the University of Southern Denmark.

Principal Investigators:

Bente Finsen (head)
Institute of Molecular Medicine
University of Southern Denmark
Webside

Martin Røssel Larsen
Institute of Biochemistry & Molecular Biology
University of Southern Denmark
Webside

Daniel Anthony
Department of Pharmacology
Oxford University

Klaus-Peter Lesch
Division of Molecular Psychiatry
University of Würzburg

Sultan Darvesh
Maritime Brain Tissue Bank
Dalhousie University

Trevor Owens
Institute of Molecular Medicine
University of Southern Denmark
Webside

Postdocs:

Current:
Livia Rosa
Institute of Biochemistry & Molecular Biology
University of Southern Denmark

Athanasios Metaxas, PhD
Institute of Molecular Medicine
University of Southern Denmark

Former:
Stefan Kempf, PhD
Institute of Biochemistry & Molecular Biology
University of Southern Denmark

PhD students:

 

Current:

Camilla Thygesen, cand. scient.

Institute of Molecular Medicine &

Institute of Biochemistry and Molecular Biology
University of Southern Denmark

 

Mithula Sivasavaraparan, cand. scient.
Institute of Molecular Medicine
University of Southern Denmark

 

 Former:

Christian Ulrich von Linstow, cand. scient.
Institute of Molecular Medicine
University of Southern Denmark

 

 Maurizio Severino, PhD, MD

Institute of Molecular Medicine
University of Southern Denmark

 

Laura Ilkjaer, PhD, cand. scient.
Institute of Molecular Medicine
University of Southern Denmark


 Recent publications:

Journal articles

Metaxas A, Vaitheeswaran R, Jensen KT, Thugesen C, Ilkjaer L, Darvesh S, Finsen B.
Reduced serotonin transporter levels and inflammation in the midbrain Raphe of 12 month old APPswe/PSEN1dE9 mice.
Curr Alzheimer Res. 2017 Oct. 4 [Epub ahead of print] PMID: 28982335

Von Linstow CU, Waider J, Grebing M, Metaxas A, Lesch KP, Finsen B.Serotonin Augmentation Therapy By Escitalopram has Minor Effects on Amyloid-β Levels In Early Stage Alzheimer's-Like Disease In Mice. Alzheimer's Research & Therapy. Accepted.

Jensen, P, Myhre CL, Lassen, PS, Metaxas, A, Khan, AM, Lamberten, KL, Babcock, AA, Finsen, B*, Larsen MR*, Kempf, SJ. TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget, July 2017. PMID: 28753583. *Equal contribution.

Olesen LØ, Sivasaravanaparan M, Severino M, Babcock AA, Bouzinova E, West MJ, Wiborg O*, Finsen B* (2017). Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine” Neurobiol Dis 104:50-60. PMID: 28461249. *Shared last-authorship.

von Linstow CU, Severino M, Metaxas A, Waider J, Babcock AA, Lesch KP, Gramsbergen JB, Finsen B (2017). Effect of aging and Alzheimer’s disease-like pathology on brain monoamines in mice. Neurochem Int 108: 238-45. PMID: 28414094.

Lassen PS, Thygesen C, Larsen MR, Kempf SJ (2017). Understanding Alzheimer's disease by global quantification of protein phosphorylation and sialylated N-linked glycosylation profiles: A chance for new biomarkers in neuroproteomics? J Proteomics 161: 11-25. PMID: 28396268.

Olesen LO, Bouzinova EV, Severino M, Sivasaravanaparan M, Hasselstrøm JB, Finsen B*, Wiborg O*. Behavioural phenotyping of APPswePS1dE9 mice: Age-related changes and effect of long-term paroxetine treatment. PLoS One 11: e0165144. PMID: 27814403. *Shared last-authorship.

Kempf S, Janik D, Barjaktarovic, Braga-Tanaka I III, Tanaka S, Neff F, Saran A, Larsen MR, Tapio S. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model. Oncotarget. Online September 2016.

Kempf SJ, Metaxas A, Ibáñez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model. Oncotarget 7: 33627-48. PMID: 27144524.

Metaxas A, Kempf SJ (2016). Neurofibrillary tangles in Alzheimer´s disease: elucidation of the molecular mechanism by immunohistochemistry and phospho-proteomics. Neural Regeneration Research  11: 1579-1581. PMID: 27904486.

Khan AM, Babcock AA, Saeed H, Myhre CL, Kassem K, Finsen B (2015). Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype. Neurobiol Aging 36:2164-75. PMID: 25892207.

Babcock AA*, Ilkjær L*, Clausen BH, Villadsen B, Dissing-Olesen L, Bendixen ATM, Lyck L, Lambertsen KL, Finsen B (2015) Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Beh Immun 48:86-101. PMID: 25774009. *Shared first-authorship.

Heneka MT, Carson MJ, Khoury JE, Landreth GE, Brosseron F, Feinstein DL, Jacobs AJ, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GA, Town T, Morgan D, Shinohara ML, Perry HV, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP (2015) Neuroinflammation in Alzheimer’s disease. Lancet Neurol 14: 389-405. PMID: 25792098 (Review).

Published conference abstracts

Sivasaravanaparan M, Severino M, Olesen LO, et al. Treatment of Ab Pathology and Microgliosis in the APPswePS1ΔE9 Mouse Model of Alzheimer's Disease. Glia, Vol 63 Suppl: 1, E181-E181, 2015 

Poster presentations at meetings and conferences:

*Presenting author

2017
Finsen B, Sivasaravanaparan M, Severino M, Olesen LØ, Metaxas A*, Bouzinova E, Babcock AA, Hasselstrøm J, Gramsbergen JB, Wiborg O. Effect of paroxetine treatment on established amyloid pathology in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Neuroscience 2017, Society for Neuroscience, Washington DC, USA.

Thygesen C*, Metaxas A, Kempf SJ, Darvesh S, Larsen MR, Finsen B. Highly increased expression of astrocytic cytokine in neocortex of Alzheimer’s patients investigated by proteomics. Keystone symposia Neuroinflammation: concepts, characteristics, consequences, Keystone, Denver, USA.

Ilkjaer L, Thygesen C, Babcock AA, Kempf SJ, Larsen MR, Finsen B*. Chronic lipopolysaccharide treatment affects cerebral amyloidosis and pathways of inflammation and synaptic plasticity in an APPswe/PS1dE9 mouse model of Alzheimer’s Disease. Keystone symposia Neuroinflammation: concepts, characteristics, consequences, Keystone, Denver, USA.

Thygesen C*, Kempf SJ, Ilkjaer L, Babcock AA, Larsen MR, Finsen B. The effect of chronic inflammation on molecular pathways of long-term potentiation in an APP/PS1 mouse model of Alzheimer Disease. Brain Prize meeting 2017, Rungsted, Denmark.
Briting S*, Metaxas A, Darvesh S, Finsen B. Association between microglial markers of neuroinflammation and translocator protein expression in neocortical tissue of patients with Alzheimer’s disease. 16th Annual OAK Meeting, Danish Brain Research Laboratories Meeting, Copenhagen, 2017.

Finsen B*, Larsen AE, Babcock AA, Darvesh S. Stereological estimation of microglial and neuronal cell numbers in Alzheimer’s disease and control brains. XIII European Meeting on Glial Cells in Health and Disease (GLIA), Edinburg, UK.

Thygesen C*, Finsen B, Larsen MR. Neuroproteomics. Bioagora 2017 - Biomarker agora 2017. University of Copenhagen, Copenhagen, Denmark.

2016:

Severino M, Sivasaravanaparan M, Ørum Olesen L, von Linstow CU, Metaxas A, Bouzinova E, Lambertsen KL, Babcock AA, Hasselstrøm J, Gramsbergen JB, Wiborg O, Finsen B*. Modulation of serotonin signaling has no effect on established amyloid pathology in the APPswePS1ΔE9 mouse model of Alzheimer's disease. Neuroprotection and Repair, Leipzig, Germany, 2016.

Kempf SJ*, Metaxas A, Ibanez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model. EMBO workshop: Mechanisms of neuronal remodeling, Seeon, Germany, 2016.

Kempf SJ*, Metaxas A, Ibanez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model. EMBO workshop: Dendritic anatomy, molecules and function, Heraklion, Greece, 2016.

Metaxas A*, Vaitheeswaran R, Jensen KT, Ilkjær L, Anzalone M, Finsen B. Examination of Alzheimer’s-related positive, negative and reactive pathology in the brainstem of APPswe/PS1ΔE9 mice. 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.

Sivasaravanaparan M*, Olesen LO, Severino M, Bouzinova E, Hajjaj AM, Metaxas A, Babcock AA, Hasselstrøm J, Wiborg O, Finsen B. Effect of Long-term Paroxetine Treatment on Aβ Pathology in the hippocampus in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease. 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.

Thygesen C*, Ilkjaer L, Babcock A, Finsen B. Chronic, systemic LPS treatment reduces cortical Aβ levels in APP/PS1 Tg mice of two backgrounds. 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.

Thygesen C*, Kempf S, Ilkjaer L, Babcock A, Larsen M, Finsen B. Elucidation of the brain inflammatory network in an APP/PS1 mouse model of Alzheimer disease. EMBO workshop in Advanced Proteomics, Varna, Italy, 2016.

2015:

Kempf SJ*, Metaxas A, Ibanez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model. Human Proteome Organization (HUPO), Vancouver, Canada, 2015.

Kempf SJ*, Metaxas A, Ibanez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model. EMBO workshop: Targeted proteomics – Experimental design and data analysis, Barcelona, Spain, 2015.

Sivasaravanaparan M*, Severino M, Olesen L O, Tenney RJ, Bouzinova E, Babcock AA, Hasselstrøm J, Gramsbergen JB, Wiborg O, Finsen B. Effect of long-term Paroxetine treatment on Amyloid Pathology and microgliosis in the APPSWE/PSDE9 mouse model of Alzheimer’s disease. Brain Prize meeting,  Middelfart, Denmark, 2015.

Sivasaravanaparan M*, Severino M, Olesen L O, Tenney RJ, Bouzinova E, Babcock AA, Hasselstrøm J, Gramsbergen JB, Wiborg O, Finsen B. Effect of Long-term Paroxetine Treatment on A Pathology and Microgliosis in the APPswePS1ΔE9 Mouse Model of Alzheimer's Disease. XII European Meeting on Glial Cells in Health and Disease, Bilbao, Spain, 2015.

 

Oral presentations at meetings and conferences:

*Presenting author

2017

Metaxas A*. Tauopathy in a mouse model of amyloidosis: Translational implications. 7th Translational Reserach Meeting on Neurological Diseases, Odense, 2017.

Metaxas A*, Vaitheeswaran R, Li S, Lamberten KL, Finsen B. Modeling progressive cognitive impairment in APPswe/PS1ΔE9 mice by using the Barnes maze test. Neuroscience 2017, Society for Neuroscience, Washington DC, USA.

Thygesen C*, Metaxas A, Kempf SJ, Darvesh S, Larsen MR, Finsen B. Quantitative proteome and PTM analysis of cerebral cortex identifies pathways of inflammation and oxidative stress to be regulated in Alzheimer’s disease cases. International student research forum, Omaha, Nebraska, USA.

Thygesen C*, Kempf SJ, Ilkjaer L, Babcock AA, Larsen MR, Finsen B. The effect of chronic inflammation on molecular pathways of long-term potentiation in an APP/PS1 mouse model of Alzheimer Disease. Brain Prize Meeting 2017, Rungsted, Denmark (Selected for poster-blitz session).
Vaitheeswaran R*, Lambertsen K, Metaxas A, Finsen B. Modeling progressive cognitive impairment in APP/PS1 mice using the Barnes Maze test. 16th Annual OAK Meeting, Danish Brain Research Laboratories Meeting, Copenhagen.
Thygesen C*, Metaxas A, Kempf SJ, Darvesh S, Larsen MR, Finsen B. Quantitative proteome and PTM analysis of cerebral cortex tissue identifies pathways of inflammation and oxidative stress to be regulated in Alzheimer’s disease cases. 16th Annual OAK Meeting, Danish Brain Research Laboratories Meeting, Copenhagen.

Finsen B*. Innate Cytokines and Serotonin as Modulators of Pathology in Alzheimer’s Disease and in Stroke’, Glia Symposium ’Grooming Glia to Nurture Neurons. Trinity College Institute of Neuroscience, Dublin. Invited talk.

2016:

Kempf SJ*, Metaxas A, Ibanez-Vea M, Darvesh S, Finsen B, Larsen MR. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model. European Proteomics Association (EuPA), Istanbul, Turkey, 2016.

Sivasaravanaparan M. Treatment with SSRI does not affect established neuropathology and behaviour in the APP/PS1 mouse model of Alzheimer's disease. Translational meeting, Odense, Denmark, 2016.

2015:

Metaxas A. ‘PET imaging of the NMDA receptor using [18F]PK209. OAK meeting, Aarhus, Denmark, 2015.

 

 

 

 

 

 

 

 


 

 

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