Ulrike Muscha Steckelings

Ulrike Muscha Steckelings
Professor Dr.med.
Position: Professor WSR in Integrative Pharmacology, University of Southern Denmark, Institute of Molecular Medicine / Dept. of Cardiovascular and Renal Research

Phone: +45 65503718
Email: usteckelings@health.sdu.dk

Research interest

The major research interest of Muscha Steckelings’ group is the angiotensin AT2-receptor, which – in contrast to the AT1-receptor – mediates tissue protective actions. Since the spectrum of protective effects of this receptor is broad (e.g. vasodilation, anti-inflammation, anti-fibrosis, anti-apoptosis, neuroregeneration), the AT2-receptor can be regarded as a potential drug target for the treatment of various diseases.

Research in the Steckelings group addresses many aspects of AT2-receptor physiology and pharmacology ranging from AT2-receptor signaling and interaction with other receptors (primarily the receptor MAS) over in vivo models for testing therapeutic efficacy of AT2-receptor stimulation (e.g. in models of diabetic or hypertensive end-organ damage, CNS diseases, fibrotic diseases, chronic inflammatory diseases, cardiovascular diseases, dermatological diseases) to the preclinical and clinical development of AT2-receptor agonists for potential future clinical use.

Methods and Techniques

Cell culture, mRNA and protein analysis, in vitro nitric oxide measurement, Immunoblotting, Immunolocalization, and Immunflorescence microscopy, ELISA techniques, Knock-out animal models.

Staff

PhD student: Antonio Augusto Bastos Peluso

Pre-graduate/Master Students: Jesper Bork Bertelsen, Camilla Bengtsen, Emil Tofte-Hansen

Technicians: Tenna Pavia Mortensen

Courses

Pharmacology and physiology for medical, biomedical and pharmacy students.

Collaborations

USA:           Prof. Colin Sumners, Prof. Michael Katovich, University of Florida, Gainesville

                  Prof. Tahir Hussain, University of Houston

Sweden:      Prof. Anders Hallberg, Prof. Mats Larhed, Uppsala University

                   Assoc. Prof. Lena Lindblad & Prof. Björn Dahlöf, University of Gothenburg

Australia:     Prof. Robert Widdop, Prof. Kate Denton, Dr. Lucinda Hilliard, Monash University

                   Prof. Karin Jandeleit-Dahm, Prof. Terri Allen, Baker IDI Heart and Diabetes Institute, Melbourne

Brazil:          Prof. Robson Santos, Federal University of Minas Gerais, Belo Horizonte

                   Assis. Prof. Daniel Villela, University of Diamantina

Austria:        Dr. Marko Poglitsch, Attoquant

Germany:     Prof. Michael Bader, Max-Delbrück Center for Molecular Medicine

                    Prof. Jonel Trebicka, University Clinics Bonn

                    Prof. Reinhard Voll and Dr. Bettina Sehnert, University of Freiburg

                    Dr. Metin Artuc, Charité – Medical Faculty Berlin

                    Dr. Mario Menk, Charité – Medical Faculty Berlin

Netherlands: Prof. Thomas Unger, Maastricht University

Italy:            Dr. Giovanna Castoldi & Prof. Andrea Stella, Università degli Studi di Milano-Bicocca

                    Prof. Carmine Savoia, Sapienza University of Rome

Slovakia:      Prof. Ludovit Paulis, University of Bratislava

                Japan:          Prof. Masatsugu Horiuchi, Ehime University

 

Membership in Societies

European Council for Cardiovascular Research (Past-President, Advisory Board)

American Heart Association

International Society of Hypertension (Committee on Women in Hypertension)

European Society of Hypertension

Danish Heart Foundation

Working group on Dermato-endocrinology

Selected publications   

84 peer-reviewed publications; 44 publications 2010 - 2015

1 book (editor); 13 book chapters

To give you the best possible experience, this site uses cookies Read more about cookies

Accept cookies