Kirsten Madsen

Kardiovaskulaer

Kirsten Madsen
Assistant Professor, MD, Ph.D.
Cardiovascular and Renal Research

Phone: +45 65503756
Email: kmadsen@health.sdu.dk

Research interest

The research group is closely associated with the Odense University Hospital and performs research at the translational level within two main areas: 

Chronic kidney injury and mechanisms of renal fibrosis

Renal fibrosis is the final common pathway in all chronic kidney diseases and is associated with loss of kidney function. Our research group focuses on elucidating novel mechanisms of renal fibrogenesis with the aim of identifying new targets for renoprotective treatment and to increase basic knowledge of extracellular matrix homeostasis. We collaborate with the Department of Nephrology, Urology and Pathology, Odense University Hospital, and we perform research projects using samples collected from patients diagnosed with chronic kidney disease, human kidney tissue, animal models of chronic kidney injury and cell culture experiments.  

Tyrosine kinase inhibitor-induced hypertension

Tyrosine kinase inhibitors (TKIs) are new drugs used in the medical treatment of several cancer diseases. A common side effect is hypertension due to an unknown mechanism. Our research group focuses on elucidating mechanisms of TKI-induced hypertension with the aim of improving anti-hypertensive treatment in this group of patients and to increase basic knowledge of blood pressure regulation. We collaborate with the Department of Oncology, Odense University Hospital, and we perform research projects using samples collected from TKI-treated patients, human kidney tissue, animal models of TKI-induced hypertension and cell culture experiments.

                   

Methods and Techniques

In vivo studies of kidney development in mice and rats

Blood pressure measurements in rats

Chronic kidney injury models in mice and rats

Transgenic animal models

Blood pressure measurements, plasma and urinary analyses in patients

Ex vivo slice culture of human kidney tissue

Analyses of human kidney tissue

Cell culture models

Stereology

RT-PCR and quantitative PCR

Western blotting, immunohistochemistry and immunofluorescence

ELISA and RIA

Staff

Ph.d. student M.sc. Anne Robdrup Tinning

Master student Tenna Gundlach Pedersen

Laboratory technician Tenna Pavia Mortensen

Courses

Bachelor module B5 ”Heart, Circulation and Respiration” (Medicine and Biomechanics)

Human Pathophysiology (Science)

Bachelor module B12 “From Health to Sick” (Medicine and Biomechanics)

Renal pathology, specialist training (hoveduddannelse) in forensic medicine

Renal developmental pathology, specialist training (hoveduddannelse) in nephrology

Animal research in experimental pathology, specialist training (hoveduddannelse) in pathology

Collaborations

Consultant Lars Bastholt, Department of Oncology, Odense University Hospital

Consultant Claus Bistrup, Department of Nephrology, Odense University Hospital

Professor Niels Marcussen, Department of Pathology, Odense University Hospital

Associate Professor Rikke Nørregaard, Institute of Clinical Medicine, Aarhus University

Professor Thomas M. Coffman, Division of Nephrology, Duke University, USA

Vladimir T. Todorov, Head of Experimental Nephrology, University of Dresden, Germany

Selected publications   

Nilsson L,  Madsen K, Krag S, Frøkiær J, Jensen BL, Nørregaard R. Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy. Am J Physiol Renal Physiol [Epub ahead of print] 

Tinning AR, Jensen BL, Schweda F, Muchara K, Hansen PB, Stubbe J, Gramsbergen J, Madsen K. The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production. Am J Physiol Renal Physiol 307:F1215-F1226,2014

Madsen K, Reddy RN, Price SR, Williams CR, Gooch JL. Nutritional intervention restores muscle but not kidney phenotypes in adult calcineurin A-alpha null mice. PLoS One 8:e62503,2013

Madsen K, Tinning AR, Marcussen N, Jensen BL. Postnatal development of the renal medulla; role of the renin-angiotensin system. Acta Physiol Scan 208:41-49,2013 

Kjærsgaard G, Madsen K, Marcussen N, Christensen S, Walter S, Jensen BL. Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase-3beta positive epithelium. Am J Physiol Renal Physiol 302:F455-F465,2012 

Nørregaard R, Madsen K, Hansen PB, Bie P, Thalingam S, Frøkiær J, Jensen BL. COX-2 disruption leads to increased central vasopressin stores in and impaired urinary concentrating ability in mice. Am J Physiol Renal Physiol 301:F1303-F1313,2011 

Madsen K, Marcussen N, Pedersen M, Kjærsgaard G, Facemire C, Coffman TM, Jensen BL. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. J Am Soc Nephrol 21:448-459,2010

Madsen K, Friis UG, Gooch JL, Hansen PB, Holmgaard L, Skøtt O, Jensen BL. Inhition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells. Kidney Int 77:110-117,2010

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