Research publications 2013-18

Data Resource Profile: Danish Conscription Registry Data (DCRD).
Christensen GT, Skogstad S, Nissen LR, Osler M.
Int J Epidemiol. 2018 Aug;47(4):1023-1024e. Pubmed abstract

Young adult cognitive ability and subsequent major depression in a cohort of 666,804 Danish men.
Christensen GT, Rozing MP, Mortensen EL, Christensen K, Osler M.
J Affect Disord. 2018 Aug;235:162-167. Pubmed abstract

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions.

Dato S, Soerensen M, Rango FD, Rose G, Christensen K, Christiansen L, Passarino G.
Aging Cell. 2018 Jun;17(3):e12755. Pubmed abstract 

DNA methylation age and perceived age in elderly Danish twins.

Debrabant B, Soerensen M, Christiansen L, Tan Q, McGue M, Christensen K, Hjelmborg J.
Mech Ageing Dev. 2018 Jan;169:40-44. Pubmed abstract

No impact of surgery on cognitive function: a longitudinal study of middle-aged Danish twins.
Dokkedal U, Wod M, Thinggaard M, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Ann Epidemiol. 2018 Feb;28(2):95-101.  Pubmed abstract

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA.
Proc Natl Acad Sci U S A. 2018 Feb;115(8):E1876-E1885. Pubmed abstract

Is male factor infertility associated with midlife low-grade inflammation? A population based study.
Hærvig KK, Kierkegaard L, Lund R, Bruunsgaard H, Osler M, Schmidt L.
Hum Fertil (Camb). 2018 Jun;21(2):146-154. Pubmed abstract

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB.
Heart 2018 Jan;104(1):30-36. Pubmed abstract

A novel healthy blood pressure phenotype in the Long Life Family Study.
Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB.
J Hypertens. 2018 Jan;36(1):43-53. Pubmed abstract

A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities.
Oksuzyan A, Singh PK, Christensen K, Jasilionis D.
Gerontologist. 2018 Nov;58(6):1156-1165. Pubmed abstract

A bidirectional association between cognitive ability in young adulthood and epilepsy: a population-based cohort study.
Osler M, Mortensen EL, Christensen K, Christensen GT.
Int J Epidemiol. 2018 Aug 1;47(4):1151-1158. Pubmed abstract

Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study.
Osler M, Rozing MP, Christensen GT, Andersen PK, Jørgensen MB.
Lancet Psychiatry. 2018 Apr;5(4):348-356. Pubmed abstract

Improvement in activities of daily living among Danish centenarians?
Rasmussen SH, Thinggaard M, Højgaard MB, Jeune B, Christensen K, Andersen-Ranberg K.
J Gerontol A Biol Sci Med Sci. 2018 Jul;73(8):1125-1131. Pubmed abstract

Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline.

Wod M, Hallas J, Andersen K, García Rodríguez LA, Christensen K, Gaist D.
Clin Gastroenterol Hepatol. 2018 May;16(5):681-689. Pubmed abstract

 

2017

Midlife Cognitive Ability, Education, and Tooth Loss in Older Danes.
Bachkati KH, Mortensen EL, Brønnum-Hansen H, Holm-Pedersen P.
J Am Geriatr Soc. 2017 Jan;65(1):194-9. Pubmed abstract

Aldringsteorier.
Christensen K, Holm E, Henriksen L.
I: Jastrup S og Holm E (red.): Sygepleje til Ældre, Kbh., Munksgaard. 2017: s. 43-52.

The association between depression and mortality - a comparison of survey- and register-based measures of depression.
Christensen GT, Maartensson S, Osler M.
J Affect Disord. 2017 Mar;210:111-4.  Pubmed abstract

NAD+ in Aging: Molecular Mechanisms and Translational Implications.
Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.
Trends Mol Med. 2017 Oct;23(10):899-916. Pubmed abstract

Mitophagy in neurodegeneration and aging.
Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner TV, Nilsen H, Bohr VA, Fang EF.
Neurochem Int. 2017 Oct;109:202-209. Pubmed abstract

Heritability of the Number of Teeth in Middle-Aged and Older Danish Twins.
Kurushima Y, Silventoinen K, Dokkedal U, Skytthe A, Mucci LA, Christensen K, Hjelmborg JVB.
J Dent Res. 2017 Dec;96(13):1513-1517. Pubmed abstract

Handgrip strength and its prognostic value for mortality in Moscow, Denmark, and England.
Oksuzyan A, Demakakos P, Shkolnikova M, Thinggaard M, Vaupel JW, Christensen K, Shkolnikov VM.
PLoS One. 2017 Sep 1;12(9):e0182684. Pubmed abstract

Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins.
Osler M, Christensen GT, Garde E, Mortensen EL, Christensen K.
Alzheimers Dement. 2017 Dec;13(12):1355-1363. Pubmed abstract

Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density.
Morris JA, Tsai PC, Joehanes R, Zheng J, Trajanoska K, Soerensen M, Forgetta V, Castillo-Fernandez JE, Frost M, Spector TD, Christensen K, Christiansen L, Rivadeneira F, Tobias JH, Evans DM, Kiel DP, Hsu YH, Richards JB, Bell JT.
J Bone Miner Res. 2017 Aug;32(8):1644-1650. Pubmed abstract

Investigation of the 5q33.3 longevity locus and age-related phenotypes.
Nygaard M, Thinggaard M, Christensen K, Christiansen L.
Aging (Albany NY). 2017 Jan 13;9(1):247-255. Pubmed abstract

The Survival of Spouses Marrying Into Longevity-Enriched Families.
Pedersen JK, Elo IT, Schupf N, Perls TT, Stallard E, Yashin AI, Christensen K.
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Pubmed abstract

Cohort Profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies - secular trends in the health and functioning of the very old.
Rasmussen SH, Andersen-Ranberg K, Thinggaard M, Jeune B, Skytthe A, Christiansen L, Vaupel JW, McGue M, Christensen K.
Int J Epidemiol. 2017 Dec 1;46(6):1746-1746j. Pubmed abstract

Limitations and risks of meta-analyses of longevity studies.
Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT.
Mech Ageing Dev. 2017 Jul;165(Pt B):139-146. Pubmed abstract

Telomeres and the natural lifespan limit in humans.
Steenstrup T, Kark JD, Verhulst S, Thinggaard M, Hjelmborg JVB, Dalgård C, Kyvik KO, Christiansen L, Mangino M, Spector TD, Petersen I, Kimura M, Benetos A, Labat C, Sinnreich R, Hwang SJ, Levy D, Hunt SC, Fitzpatrick AL, Chen W, Berenson GS, Barbieri M, Paolisso G, Gadalla SM, Savage SA, Christensen K, Yashin AI, Arbeev KG, Aviv A.
Aging (Albany NY). 2017 Apr;9(4):1130-1142. Pubmed abstract

2016

The association between intelligence and lifespan is mostly genetic.
Arden R, Luciano M, Deary IJ, Reynolds CA, Pedersen NL, Plassman BL, McGue M, Christensen K, Visscher PM.
International Journal of Epidemiology 2016;45(1):178-85. Pubmed abstract 

Healthy ageing, the genome and the environment
Christensen K & McGue M.
Nat Rev Endocrinol 2016 Jul;12(7):378-80. Pubmed abstract

Cognitive functioning after surgery in middle-aged and elderly Danish twins.
Dokkedal U, Hansen TG, Rasmussen LS, Mengel-From J, Christensen K.
Anesthesiology 2016;124(2):312-21. Pubmed abstract

Leucocyte Telomere Length and risk of cardiovascular disease in a cohort of 1397 Danish men and women.
Ellehøj H, Bendix L, Osler M. 
Cardiology 2016;133(3):173-7. Pubmed abstract

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity.
Flachsbart F, Ellinghaus D, Gentschew L, Heinsen FA, Caliebe A, Christiansen L, Nygaard M, Christensen K, Blanché H, Deleuze JF, Derbois C, Galan P, Büning C, Brand S, Peters A, Strauch K, Müller-Nurasyid M, Hoffmann P, Nöthen MM, Lieb W, Franke A, Schreiber S, Nebel A.
Aging Cell. 2016 Jun;15(3):585-8. Pubmed abstract

Mortality is written on the face.
Gunn DA, Larsen LA, Lall JS, Rexbye H, Christensen K.
Journal of Gerontology. Series A, Biological Sciences and Medical Sciences 2016; 71(1):72-7. Pubmed abstract

The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks.
Hyun M, Choi S, Stevnsner T, Ahn B.
Cell Signal. 2016 Mar;28(3):214-23. Pubmed abstract

Somatically acquired structural genetic differences: a longitudinal study of elderly Danish twins.
Magaard Koldby K, Nygaard M, Christensen K, Christiansen L.
Eur J Hum Genet. 2016 Oct;24(10):1506-10. Pubmed abstract

Is Intelligence in Early Adulthood Associated With Midlife Physical Performance Among Danish Males?
Meincke RH, Osler M, Mortensen EL, Hansen ÅM.
J Aging Health. 2016 Apr;28(3):530-45. Pubmed abstract

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment.
Nygaard M, Debrabant B, Tan Q, Deelen J, Andersen-Ranberg K, de Craen AJ, Beekman M, Jeune B, Slagboom PE, Christensen K, Christiansen L.
Aging Cell 2016; 15(1):49-55. Pubmed abstract

Cancer and aging: Epidemiology and methodological challenges.
Pedersen JK, Engholm G, Skytthe A, Christensen K; Academy of Geriatric Cancer Research (AgeCare).
Acta Oncologica 2016;55 Suppl 1:7-12. Pubmed abstract

G×E Interaction Influences Trajectories of Hand Grip Strength.
Petersen I, Pedersen NL, Rantanen T, Kremen WS, Johnson W, Panizzon MS, Christiansen L, Franz CE, McGue M, Christensen K, Hamdi NR, Krueger RF, Reynolds C.
Behavior Genetics 2016; 46(1):20-30. Pubmed abstract

Gene-environment interplay in physical, psychological, and cognitive domains in mid to late adulthood: Is APOE a variability gene?
Reynolds CA, Gatz M, Christensen K, Christiansen L, Dahl Aslan AK, Kaprio J, Korhonen T, Kremen WS, Krueger R, McGue M, Neiderhiser JM, Pedersen NL; IGEMS
consortium.
Behavior Genetics 2016; 46(1):4-19. Pubmed abstract

No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.
Sørensen M, Nygaard M, Debrabant B, Mengel-From J, Dato S, Thinggaard M, Christensen K, Christiansen L.
Experimental Gerontology 2016;1;78:57-61. Pubmed abstract

Survival prognosis in very old adults.
Thinggaard M, McGue M, Jeune B, Osler M, Vaupel JW, Christensen K.
Journal of the American Geriatrics Society 2016;64(1):81-8. Pubmed abstract

Novel loci and pathways significantly associated with longevity.
Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW.
Scientific Reports, 2016; 6:21243.Pubmed abstract

Unilateral ureteral obstruction induces DNA repair by APE1.
Aamann MD, Norregaard R, Kristensen ML, Stevnsner T, Frøkiær J.
Am J Physiol Renal Physiol. 2016 Apr;310(8):F763-F776. Pubmed abstract

2015

Risk of sex-specific cancers in opposite-sex and same-sex twins in Denmark and Sweden.
Ahrenfeldt LJ, Skytthe A, Möller S, Czene K, Adami HO, Mucci LA, Kaprio J, Petersen I, Christensen K, Lindahl-Jacobsen R.
Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1622-8. Pubmed abstract

Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study.
Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):971-6. Pubmed abstract

Operational Definition of Active and Healthy Ageing (AHA): A Conceptual Framework.
Bousquet J, Andersen Ranberg K et al.
J Nutr Health Aging. 2015;19(9):955-60. Pubmed abstract

Educational inequalities in health expectancy during the financial crisis in Denmark.
Brønnum-Hansen H, Baadsgaard M, Eriksen ML, Andersen-Ranberg K, Jeune B.
Int J Public Health. 2015 Dec;60(8):927-35. Pubmed abstract

Gender-specific modifying effect on the educational disparities in the impact of smoking on health expectancy.
Brønnum-Hansen H, Jeune B.
Eur J Public Health. 2015 Jun;25(3):477-81. Pubmed abstract

Cohort Profile: The Danish Conscription Database(DCD): A cohort of 728 160 men born from 1939 through 1959.
Christensen GT, Molbo D, Angquist LH, Mortensen EL, Christensen K, Sørensen TI, Osler M.
Int J Epidemiol. 2015 Apr;44(2):432-40. Pubmed abstract

Tremor in the elderly: Essential and aging-related tremor.
Deuschl G, Petersen I, Lorenz D, Christensen K.
Mov Disord. 2015 Sep;30(10):1327-34. Pubmed abstract

A Population-Based Study of Cholesterol Measurements in the Oldest Old.
Gils C, Christensen K, Nybo M.
Curr Aging Sci. 2015;8(3):282-7. Pubmed abstract

Paternal age and telomere length in twins: the germ stem cell selection paradigm.
Hjelmborg JB, Dalgård C, Mangino M, Spector TD, Halekoh U, Möller S, Kimura M, Horvath K, Kark JD, Christensen K, Kyvik KO, Aviv A.
Aging Cell. 2015 Aug;14(4):701-3. Pubmed abstract

Heritability of telomere length in a study of long-lived families.
Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N.
Neurobiol Aging. 2015 Oct;36(10):2785-90. Pubmed abstract

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
Jelenkovic A, Christensen K, Skytthe A, Kyvik KO, Tan Q, McGue M et al.
Twin Res Hum Genet. 2015 Oct;18(5):557-70. Pubmed abstract

Improvement in health expectancy at ages 50 and 65 in Denmark during the period 2004-2011.
Jeune B, Eriksen ML, Andersen-Ranberg K, Brønnum-Hansen H.
Scand J Public Health. 2015 May;43(3):254-9. Pubmed abstract

Når kroppen reparerer DNA.
[When the body is reparing it's own DNA]
Lautrup SH, Stevnsner T.
Aktuel Naturvidenskab. 2015;6(28-33).

DCAF4, a novel gene associated with leucocyte telomere length.
Mangino M, Christiansen L, Stone R, Hunt SC, Horvath K, Eisenberg DT, Kimura M, Petersen I, Kark JD, Herbig U, Reiner AP, Benetos A, Codd V, Nyholt DR, Sinnreich R, Christensen K, Nassar H, Hwang SJ, Levy D, Bataille V, Fitzpatrick AL, Chen W, Berenson GS, Samani NJ, Martin NG, Tishkoff S, Schork NJ, Kyvik KO, Dalgård C, Spector TD, Aviv A.
J Med Genet. 2015 Mar;52(3):157-62. Pubmed abstract

Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance.
Maynard S, Keijzers G, Hansen AM, Osler M, Molbo D, Bendix L, Møller P, Loft S, Moreno-Villanueva M, Bürkle A, Hvitby CP, Schurman SH, Stevnsner T, Rasmussen LJ, Avlund K, Bohr VA.
Acta Physiol (Oxf). 2015 Jan;213(1):156-70. Pubmed abstract

Intelligence in early adulthood and mortality from natural and unnatural causes in middle-aged Danish men.
Meincke RH, Mortensen EL, Avlund K, Rosthøj S, Sørensen HJ, Osler M. 
J Epidemiol Community Health. 2014 ;68:130-6. Pubmed abstract

The APP A673T frequency differs between Nordic countries.
Mengel-From J, Jeune B, Pentti T, McGue M, Christensen K, Christiansen L.
Neurobiol Aging. 2015 Oct;36(10):2909.e1-4. Pubmed abstract

Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.
Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8. Pubmed abstract

Perceived age is associated with bone status in women aged 25-93 years.
Nielsen BR, Linneberg A, Christensen K, Schwarz P.
Age (Dordr). 2015 Dec;37(6):106. Pubmed abstract

Association between leukocyte telomere length and bone mineral density in women 25-93years of age.
Nielsen BR, Linneberg A, Bendix L, Harboe M, Christensen K, Schwarz P.
Exp Gerontol. 2015 Jun;66:25-31. Pubmed abstract

Sex Differences in Biological Markers of Health in the Study of Stress, Aging and Health in Russia.
Oksuzyan A, Shkolnikova M, Vaupel JW, Christensen K, Shkolnikov VM.
PLoS One. 2015 Jun 29;10(6):e0131691. Pubmed abstract

Lifetime socio-economic position and depression: an analysis of the influence of cognitive function, behaviour and inflammatory markers.
Osler M, Bruunsgaard H, Lykke Mortensen E.
Eur J Public Health. 2015 Dec;25(6):1065-9. Pubmed abstract

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
Pedersen JK, Skytthe A, McGue M, Honig LS, Franceschi C, Kirkwood TB, Passarino G, Slagboom PE, Vaupel JW, Christensen K.
Ann Epidemiol. 2015 Aug;25(8):569-574.e3. Pubmed abstract

Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.
Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, Liu Y, Christensen K, Kammerer CM.
Am J Epidemiol. 2015 Dec 1;182(11):926-35. Pubmed abstract

Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals.
Soerensen M, Nygaard M, Dato S, Stevnsner T, Bohr VA, Christensen K, Christiansen L.
Aging Cell. 2015 Feb;14(1):60-6. Pubmed abstract

Regulation of the human Suv3 helicase on DNA by inorganic cofactors.
Venø ST, Witt MB, Kulikowicz T, Bohr VA, Stevnsner T.
Biochimie. 2015 Jan;108:160-8. Pubmed abstract

Physical and mental decline and yet rather happy? A study of Danes aged 45 and older.
Vestergaard S, Thinggaard M, Jeune B, Vaupel JW, McGue M, Christensen K.
Aging Ment Health. 2015 May;19(5):400-8. Pubmed abstract 

2014

The Danish Centenarian Program: Cardiovascular diseases in Danish Centenarians.
Andersen-Ranberg K, Christensen K, Jeune B.
Eur Geriatr Med. 2014 Sep;5:Suppl 1, p.S15.

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: The Long Life Family Study (LLFS).
An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WH, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA.
Metabolism. 2014 Apr;63(4):461-8. Pubmed abstract

Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly.
Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R; for the Long Life Family Study.
JAMA Neurol. 2014 Dec;71(12):1514-9. Pubmed abstract

Longitudinal changes in leukocyte telomere length and mortality in humans.
Bendix L, Thinggaard M, Fenger M, Kolvraa S, Avlund K, Linneberg A, Osler M.
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):231-9. Pubmed abstract

Association of leukocyte telomere length with fatigue in nondisabled older adults.
Bendix L, Thinggaard M, Kimura M, Aviv A, Christensen K, Osler M, Avlund K.
J Aging Res. 2014;2014:403253. Pubmed abstract

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing).
Cevenini E, Cotichini R, Stazi MA, Toccaceli V, Palmas MG, Capri M, De Rango F, Dato S, Passarino G, Jeune B, Franceschi C; GEHA Project Consortium.
Age (Dordr). 2014 Apr;36(2):949-66. Pubmed abstract

The Genome and ageing.
Christiansen L, Christensen K.
Ugeskr Laeger. 2014 Nov;176(46). Pubmed abstract

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.
Dato S, Soerensen M, Lagani V, Montesanto A, Passarino G, Christensen K, Tan Q, Christiansen L.
Exp Gerontol. 2014 Apr;52:23-9. Pubmed abstract

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.
Debrabant B, Soerensen M, Flachsbart F, Dato S, Mengel-From J, Stevnsner T, Bohr VA, Kruse TA, Schreiber S, Nebel A, Christensen K, Tan Q, Christiansen L.
Eur J Hum Genet. 2014 Sep;22(9):1131-6. Pubmed abstract

Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol.
Feitosa MF, Wojczynski MK, Straka R, Kammerer CM, Lee JH, Kraja AT, Christensen K, Newman AB, Province MA, Borecki IB.
Front Genet. 2014 Jun 3;5:159. Pubmed abstract

Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis.
Friis-Ottessen M, Bendix L, Kølvraa S, Norheim-Andersen S, De Angelis PM, Clausen OP.
BMC Gastroenterol. 2014 Jan 9;14:8. Pubmed abstract

Gender and telomere length: systematic review and meta-analysis.
Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, De Meyer T, Deary I, Der G, Diez Roux A, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li C, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y; Halcyon study team.
Exp Gerontol. 2014 Mar;51:15-27. Pubmed abstract

Occupational characteristics and cognitive aging in the Glostrup 1914 cohort.
Gow A, Avlund K, Mortensen EL.
J Gerontol Psych Sci.
2014 Mar;69(2):228-36. Pubmed abstract

Psychosocial factors at work and the development of mobility limitations among adults in Denmark.
Hansen AM, Darsø L, Manty M, Nilsson C, Christensen U, Lund R, Holtermann A, Avlund K.
Scand J Public Health. 2014 Mar 17;42(5):417-424. Pubmed abstract

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
Kulminski AM, Arbeev KG, Culminskaya I, Arbeeva L, Ukraintseva SV, Stallard E, Christensen K, Schupf N, Province MA, Yashin AI.
PLoS Genet. 2014 Jan;10(1):e1004141. Pubmed abstract

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R.
Front Genet. 2014 Jan;4:310. Pubmed abstract

Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study.
Madsen M, Andersen PK, Gerster M, Andersen AM, Christensen K, Osler M.
Soc Sci Med. 2014 Oct;118:182-90. Pubmed abstract

The nature of behavioural correlates of healthy ageing: a twin study of lifestyle in mid to late life.
McGue M, Skytthe A, Christensen K.
Int J Epidemiol. 2014 Jun;43(3):775-82. Pubmed abstract

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly.
Mengel-From J, Thinggaard M, Dalgård C, Kyvik KO, Christensen K, Christiansen L.
Hum Genet. 2014 Sep;133(9):1149-59. Pubmed abstract

Best lung function equations for the very elderly selected by survival analysis.
Miller MR, Thinggaard M, Christensen K, Pedersen OF, Sigsgaard T.
Eur Respir J. 2014 May;43(5):1338-46. Pubmed abstract

Indoor mobility-related fatigue and muscle strength in nonagenarians: a prospective longitudinal study.
Mänty M, Ekmann A, Thinggaard M, Christensen K, Avlund K.
Aging Clin Exp Res. 2014 Feb;26(1):39-46. Pubmed abstract

Musculoskeletal pain and physical functioning in the oldest old.
Mänty M, Thinggaard M, Christensen K, Avlund K.
Eur J Pain. 2014 Apr;18(4):522-9. Pubmed abstract

Genetic determinants of healthy aging - Studies of genetic variation associated with human longevity
Nygaard M.
Ph.d.-afhandling, Syddansk Universitet, 2014 Jul.

Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.
Nygaard M, Lindahl-Jacobsen R, Soerensen M, Mengel-From J, Andersen-Ranberg K, Jeune B, Vaupel JW, Tan Q, Christiansen L, Christensen K.
Exp Gerontol. 2014 Sep;57C:41-6. Pubmed abstract

Sex differences in health and mortality in Moscow and Denmark.
Oksuzyan A, Shkolnikova M, Vaupel JW, Christensen K, Shkolnikov VM.
Eur J Epidemiol. 2014 Apr;29(4):243-52. Pubmed abstract

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.
Raule N, Sevini F, Li S, Barbieri A, Tallaro F, Lomartire L, Vianello D, Montesanto A, Moilanen JS, Bezrukov V, Blanché H, Hervonen A, Christensen K, Deiana L, Gonos ES, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Eline Slagboom P, Spazzafumo L, Antonietta Stazi M, Toussaint O, Vaupel JW, Rose G, Majamaa K, Perola M, Johnson TE, Bolund L, Yang H, Passarino G, Franceschi C.
Aging Cell. 2014 Jun;13(3):401-7. Pubmed abstract

Heritability of and mortality prediction with a longevity phenotype: The Healthy Aging Index.
Sanders JL, Minster RL, Barmada MM, Matteini AM, Boudreau RM, Christensen K, Mayeux R, Borecki IB, Zhang Q, Perls T, Newman AB.
J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):479-85. Pubmed abstract

Associations between xerostomia, histopathological alterations, and autonomic innervation of labial salivary glands in men in late midlife.
Sørensen CE, Larsen JO, Reibel J, Lauritzen M, Mortensen EL, Osler M, Pedersen AM.
Exp Gerontol. 2014 Sep;57:211-7. Pubmed abstract

Hierarchical linear modelling of longitudinal pedigree data for genetic association analysis.
Tan Q, Hjelmborg J, Thomassen M, Jensen AK, Christiansen L, Christensen K, Zhao JH, Kruse TA.
BMC Proceedings. 2014 Jun, 8(Suppl 1):S82.

Power estimation for gene-longevity association analysis using concordant twins.
Tan Q, Zhao JH, Kruse T, Christensen K.
Genet Res Int. 2014 Sep;2014:154204. Pubmed abstract

Genetic variants associated with lung function: the long life family study.
Thyagarajan B, Wojczynski M, Minster RL, Sanders J, Barral S, Christiansen L, Barr RG, Newman A; CHARGE consortium, SpiroMeta consortium.
Respir Res. 2014 Nov 1;15(1):134. Pubmed abstract

Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.
Aamann MD, Hvitby C, Popuri V, Muftuoglu M, Lemminger L, Skeby CK, Keijzers G, Ahn B, Bjørås M, Bohr VA, Stevnsner T.
Mech Ageing Dev. 2014 Jan;135:1-14. Pubmed abstract

2013

Avlund K.
Fatigue, fatigability and aging.
Fatigue: Biomedicine, Health and Behavior. 2013; 1: 43-63.

Christensen K, Thinggaard M, Oksuzyan A, Steenstrup T, Andersen-Ranberg K, Jeune B, McGue M, Vaupel JW.
Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart.
Lancet. 2013 Nov;382(9903):1507-13. Pubmed abstract

Engberg H, Jeune B, Andersen-Ranberg K, Martinussen T, Vaupel JW, Christensen K.
Optimism and survival: does an optimistic outlook predict better survival at advanced ages? A twelve-year follow-up of Danish nonagenarians.
Aging Clin Exp Res. 2013 Oct;25(5):517-25. Pubmed abstract

Ekmann A, Petersen I, Mänty M, Christensen K, Avlund K.
Fatigue, General Health, and Ischemic Heart Disease in Older Adults.
J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):279-85. Pubmed abstract

Fieo RA, Mortensen EL, Rantanen T, Avlund K.
Improving a measure of mobility-related fatigue (the mobility-tiredness scale) by establishing item intensity.
J Am Geriatr Soc. 2013 Mar;61(3):429-33. Pubmed abstract

Frost M, Petersen I, Hegedüs L, Christiansen L, Brix T, Christensen K.
Regulation of the pituitary-thyroid axis in adulthood is not related to birth weight: Evidence from extremely birth weight-discordant monozygotic Danish twin pairs.
Thyroid. 2013 Jul;23(7):785-90. Pubmed abstract

Garm C, Moreno-Villanueva M, Bürkle A, Petersen I, Bohr VA, Christensen K, Stevnsner T.
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells.
Aging Cell. 2013 Feb;12(1):58-66. Pubmed abstract 

Garm C, Moreno-Villanueva M, Bürkle A, Larsen LA, Bohr VA, Christensen K, Stevnsner T.
Genetic and environmental influence on DNA strand break repair: A twin study.
Environ Mol Mutagen. 2013 Jul;54(6):414-20. Pubmed abstract

Harbo M, Delaisse JM, Kjaersgaard-Andersen, Soerensen FB, Koelvraa S, Bendix L.
The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis.
Mech Ageing Dev. 2013 Sep;134(9):367-72. Pubmed abstract

Idland G, Pettersen R, Avlund K, Bergland A.
Physical performance as long-term predictor of onset of ADL disability: A nine-year longitudinal study among community-living older women.
Arch Gerontol Geriatr. 2013 Jan; S0167-4943(12)00244-0. Pubmed abstract

Kristensen U, Epanchintsev A, Rauschendorf MA, Laugel V, Stevnsner T, Bohr VA, Coin F, Egly JM.
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2261-70. Pubmed abstract

Lindahl-Jacobsen R, Hanson HA, Oksuzyan A, Mineau GP, Christensen K, Smith KR.
The male-female health-survival paradox and sex differences in cohort life expectancy in Utah, Denmark, and Sweden 1850-1910.
Ann Epidemiol. 2013 Apr;23(4):161-6. Pubmed abstract

Lindahl-Jacobsen R, Tan Q, Mengel-From J, Christensen K, Nebel A, Christiansen L.
Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):389-94. Pubmed abstract

Maynard S, Keijzers G, Gram M, Desler C, Bendix L, Budtz-Jørgensen E, Molbo D, Croteau DL, Osler M, Stevnsner T, Rasmussen LJ, Dela F, Avlund K, Bohr VA.
Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells.
Aging (Albany NY). 2013 Nov;5(11):850-64. Pubmed abstract

Oksuzyan A, Jeune B, Juel K, Vaupel JW, Christensen K.
Changes in hospitalisation and surgical procedures among the oldest-old: A follow-up study of the entire Danish 1895 and 1905 cohorts from ages 85 to 99 years.
Age Ageing. 2013 Jul;42(4):476-81. Pubmed abstract

Steenstrup T, Hjelmborg JV, Mortensen LH, Kimura M, Christensen K, Aviv A.
Leukocyte telomere dynamics in the elderly.
Eur J Epidemiol. 2013 Feb;28(2):181-7. Pubmed abstract

Steenstrup T, Hjelmborg JV, Kark JD, Christensen K, Aviv A.
The telomere lengthening conundrum - artifact or biology?
Nucleic Acids Res. 2013 Jul;41(13):e131. Pubmed abstract

Tan Q, Christiansen L, Thomassen M, Kruse TA, Christensen K.
Twins for epigenetic studies of human aging and development.
Ageing Res Rev. 2013 Jan;12(1):182-7. Pubmed abstract

Tan Q, Sørensen M, Kruse TA, Christensen K, Christiansen L.
A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family.
Ageing Cell. 2013 Aug;12(4):690-4. Pubmed abstract

Aamann MD, Muftuoglu M, Bohr VA, Stevnsner T.
Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance.
Mech Ageing Dev. 2013 May-Jun;134(5-6):212-24. Pubmed abstract

To give you the best possible experience, this site uses cookies Read more about cookies

Accept cookies