Inflammatory cells and mechanisms contribute to shape the nervous system during development, and inflammation is involved in the pathogenesis of the majority of neurologic as well as psychiatric disorders.
In the BRIDGE Neuroinflammation Team we bring together basic and clinical scientists to understand how inflammation can be of benefit to the central and peripheral nervous system, in particular in development, and as part of homeostatic processes, and neural plasticity and repair, through normal aging and in disease. Inflammation also contributes to neuropathology, and can aggravate and even induce pathology. We want to understand how this dysregulation occurs and how to restore normal homeostasis.
Neuroinflammation research is at the interface between neurobiology and immunology. Our multidisciplinary Team takes advantage of insights and material from clinical cohorts/biobanks for direct application to animal and in vitro systems and for combining cellular, molecular and ‘omics’ technologies with state-of-the-art imaging and behavioral studies.
The ambition is that the synergy resulting from these collaborations will lead to improved therapies for neurologic disease and deeper understanding of the mechanisms underlying normal health and aging.