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Susanne Mandrup

Susanne Mandrup is Professor at Department of Biochemistry and Molecular Biology, University of Southern Denmark, Director of Center of Excellence in Functional Genomics and Tissue Plasticity (ATLAS) and head of the Functional Genomics & Metabolism Research Unit. In addition, she is Chair of Biochemistry and Molecular Biology in the Danish Institute of Advanced Study

Susanne Mandrup obtained her PhD in Biochemistry from University of Southern Denmark (former Odense University) in 1992 and worked among others as a post doc in Prof. M. Daniel Lane’s group, Department of Biological Chemistry, Johns Hopkins University, Baltimore 1995-96. In 1996, she was recruited back to Odense as Assistant Professor and has since 2008 been full professor.

She has received numerous awards and major grants including a Sapere Aude Advanced Grant from the Danish Independent Research Council in 2012, the Advanced Grant from the Novo Nordisk Foundation in 2015. In 2017 she received a grant from the Danish National Research Foundation for the establishment of a Center of Excellence, ATLAS. She is member of the Royal Danish Academy of Sciences and Letters and European Molecular Biology Organization (EMBO).

She was member of the Danish Natural Science Research Council (2005-2010) and has since 2009 been member of committees under the Novo Nordisk Foundation, recently as chair of the Committee on Bioscience and Basic Biomedicine. Since 2013 she has been involved with European Research Council panels and is currently chair of the Consolidator Panel for Genetics, Genomics, Bioinformatics and Systems Biology.

You can read more about the Mandrup Group at the Mandrup Group website.

Head of research: Professor Susanne Mandrup

Research group: 
HCA Academy Professor Gordon Hager

Center administrator Louise Cathrine Braun Elmelund-Præstekær

Postdoc Maria Stahl Madsen
Postdoc Jesper Grud Skat Madsen 
Postdoc Lingzi Li
Postdoc Anitta KInga Sarvari

Academic staff (Laboratory Manager) Ronni Nielsen
Academic staff Alexander Rauch

PhD Fellow Martin Rønn Madsen
PhD Fellow Elvira Laila van Hauwaert
PhD Fellow Lasse Kruse Markussen
PhD Fellow Kari Østerli Frafjord

PhD student Lasse Lehtonen
PhD student Mike Krogh Terkelsen
PhD student Maja Worm Andersen
PhD student Mette Larsen
Business PhD student Julia Peics

Research Associate & PA to Susanne Mandrup Ann-Britt Marcher

Research assistant Maria Victoria Mikkelsen

Laboratory technician Tenna Pavia Mortensen
Laboratory technician intern Sarah Wædele-Albrektsen
Laboratory technician MaibrithWishoff

 

Transcriptional networks in the regualtion of differentiation and metabolism

The research in the Mandrup Group focuses on understanding transcriptional networks regulating metabolism and stem cell development of mammalian cells. We are specifically interested in the molecular cross-talk between transcriptional regulation and metabolism in fat cells and the insulin-producing beta-cells in the pancreas, and in the transcriptional network regulating fat cell development. Fat cells and beta-cells play a central role in the etiology of insulin resistance and type II diabetes, and maintenance of proper carbohydrate/lipid homeostasis in these cells are of outmost importance for whole body physiology. The Mandrup Group investigates these regulatory mechanisms in cell culture and murine model systems as well as in human biopsies. They use a combination of detailed molecular studies and genome-wide next generation sequencing-based approaches.

Current research projects

For more information on current research projects in the Mandrup group please visit the Mandrup group website.

Selected publications

Extensive chromatin remodeling and establishment of transcription factor ‘hotspots’ during early adipogenesis 
Siersbæk, R.; Nielsen, R.; John, S.; Sung, M.-H.; Baek, S.; Loft, A.; Hager, G. L.; Mandrup, S.EMBO J, 2011, 30, rel="noopener noreferrer" 1459-72

Delayed hepatic adaptation to weaning in ACBP-/- mice is caused by disruption of the epidermal barrier 
Neess, D.; Bek, S.; Marcher, A.-B.; Bloksgaard, M.; Færgeman, N.; Mandrup, S.Cell  Reports, 2013, 5, 1403-1412

Transcription factor cooperativity in early adipogenic hotspots and super-enhancers 
Siersbæk, R.; Rabiee, A.; Nielsen, R.; Sidoli, S.; Loft, A.; Poulsen, L. L. C.; Rogowska-Wrzesinska, A.; Jensen, O. N.; Mandrup, S., Cell Reports, 2014, 7(5), 1413-1455

A full list of publications by professor Susanne Mandrup can be found here.


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