Kedar Natarajan is a Danish-Institute of Advanced Study (D-IAS) Assistant Professor at the Department of Biochemistry and Molecular Biology (BMB) since March 2018. He received his PhD from Imperial College London in 2013, followed by a joint postdoctoral appointment at Wellcome Sanger Institute and European Bioinformatics Institute, Cambridge, UK. His educational background includes a Master’s and Bachelor’s degree in Biotechnology and a Dual Bachelor’s in Computer Sciences from India.
During PhD and postdoc, Kedar has utilised systems approaches to understanding fundamental process during embryonic development. He has extensive experience with high–throughput single-cell genomics approaches and computational analysis including important publications from his postdoc. Kedar has also been a recipient of prestigious funding’s and awards including Medical Research Council (MRC)-Centenary Award, MRC-Career Development Fellowship and Marie Curie PhD fellowship among others.
Head of research: Kedar Natarajan
Kedar’s research investigates the fundamental process of cell cycle during embryonic development (embryonic stem cells) at single-cell resolution using state-of-art imaging, genome editing, next-generation sequencing and functional genomics technologies. Simply, understanding how a single fertilized cell during development divides, scales and generates the incredible complexity of cell types, tissues and organs within human body. Kedar and his team focus on understanding how the crosstalk between cell cycle and gene expression influences cell-fate decisions in embryonic stem cells. The lab utilizes a wide variety of wet- and dry-lab tools to explore the mechanisms involved during cell-fate decisions and during dysregulation in genetic defects and diseases.
For more details on research work and current projects contact PI directly: firstname.lastname@example.org
You can find the D-IAS profile here
Single cell transcriptomics of pluripotent stem cells: reprogramming and differentiation.
Natarajan KN#, Teichmann SA, Kolodziejczyk AA.
Curr Opin Genet Dev. 2017 Oct;46:66-76. Epub 2017 Jul 1. Review.
Power analysis of single-cell RNA-sequencing experiments.
Svensson V, Natarajan KN1*, Ly LH, Miragaia RJ, Labalette C, Macaulay IC, Cvejic A, Teichmann SA.
Nat Methods. 2017 Apr;14(4):381-387. Epub 2017 Mar 6.
1*Joint first author
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.
Kolodziejczyk AA, Kim JK, Tsang JC, Ilicic T, Henriksson J, Natarajan KN, Tuck AC, Gao X, Bühler M, Liu P, Marioni JC, Teichmann SA.
Cell Stem Cell. 2015 Oct 1;17(4):471-85.
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.
Buettner F1*, Natarajan KN1*, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC, Stegle O.
Nat Biotechnol. 2015 Feb;33(2):155-60. Epub 2015 Jan 19.
1*Joint first author
Full list of publications can be found here.