The Department of Chemistry was established in 1966, and in the following years the departments of Biochemistry (1967), Molecular Biology (1968) Physics (1970) were established. Until 1972, these departments provided teaching solely for medical students while simultaneously planning a number of degree programmes within Science which meant that in 1972, 300 students were admitted to a joint basic degree programme in Science and Medicine.
The Department of Mathematics was founded in 1972, followed by the Department of Biology in 1973. With these additions, a full Science palette was represented at the university. In 1974 the Danish Ministry of Education sent out a ministerial order on the Master's degree programmes in Science, and an independent Faculty of Science was established subsequently.
In the 1990s the number of Engineering degree programmes increased. Therefore, the Department of Data Technology was established in the mid-1990s, and the Faculty of Science changed its name into the Faculty of Science and Engineering. In 1997 the Department of Data Technology was rebranded as the Maersk Mc-Kinney Moller Institute when A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal granted DKK 80 million to the building and running of the department. The new building was inaugurated in 1999.
Meanwhile, the University of Southern Denmark was established as a merger in August 1998. As a consequence of the merger, the Faculty of
Science and Engineering became responsible for the university's engineering activities in Sønderborg, including the then newly established (1999) Mads Clausen Institute, which was established on the basis of a multi-annual grant from Bitten & Mads Clausen's Foundation.
When the Odense University College of Engineering merged with SDU in 2006, an independent Faculty of Engineering was established, taking over several activities, including the Maersk Mc-Kinney Moller Institute and the Mads Clausen Institute. This resulted in an adjustment of the faculty's activities and a return to its original name: The Faculty of Science.
Over the years, several other organisational changes have taken place. In 1988 the Department of Mathematics was renamed the Department of Mathematics and Computer Science. In 2000, the Department of Biochemistry and the Department of Molecular Biology merged into the Department of Biochemistry and Molecular Biology, and in 2006 the Department of Physics and the Department of Chemistry were joined in what is presently the Department of Physics, Chemistry and Pharmacy.