Jan-Wilhelm Kornfeld

Jan-Wilhelm Kornfeld studied Biochemistry and received undergraduate training in Physiology, Immunology, and Cancer Biology and in 2008 obtained a PhD in Cell Biology from University of Kiel, Germany. 

Between 2009-2013 he worked as postdoctoral researcher with Professor Jens Brüning at the Institute for Genetics, Köln, Germany where he delineated novel noncoding RNA (microRNA) signaling pathways controlling liver glucose homeostasis in transgenic mice and human type 2 diabetic mellitus (T2D) patients (Kornfeld 2013 Nature). 

In 2014, he obtained a Emmy-Noether Programme Grant for Scientific Excellence from the German Research Foundation DFG, and started his independent research group at the Max Planck Institute for Metabolism Research (MPI-MR) in Köln. At the MPI-MR, his work focussed on noncoding RNA regulatory principles in adipose tissue plasticity and thermogenesis and how these affect energy homeostasis and the development of metabolic diseases like obesity and T2D. 

In 2016, he obtained an European Research Council (ERC) Starting Grant for his interest in liver metabolic regulation by long noncoding RNAs and intergenerational epigenetic programming of metabolism by germline noncoding RNAs.  

Since 2018, Jan-Wilhelm Kornfeld was recruited as Full Danish Diabetes Academy (DDA) Professor for Molecular Biology of Metabolic Disease and is Co-Founder of the NNF-funded Center for Adipocyte Signaling (ADIPOSIGN).


Research Group:
Professor Jan-Wilhelm Kornfeld
Lab Manager Bjørk Ditlev Larsen 
Senior Scientist Eduardo Fernandez-Rebollo 
Postdoc Ajeetha Josephrajan 
Postdoc Joo Hyun Park 
Postdoc Marta Pradas-Juni 
Postdoc Hande Topel 
Postdoc Bernardo Moreira Suares Oliveria 
PhD project student Chien Huang 
PhD fellow Christoph Kiefer 
PhD fellow Rocio Valdebenito Malmros 
Research Assistant Laura Ingebord Davidsen 
MSc project student Elma Barudzija 
BSc project student Anne Katherine Søgaard Terp  
Laboratory Technician Maibrith Wishoff (with ADIPOSIGN partner Mandrup) 


Core technologies:
• Gene delivery by adeno-associated viruses (AAV) and development of novel AAV vector systems for targeted somatic gene transfer.
• Generation and phenotypisation of transgenic animal models of obesity and T2D. 
• Next Generation (mRNA, microRNA, and Nanopore Full RNA) Sequencing.
• Antisense oligonucleotide and LNA GapmeR mediated gene silencing in mice.
• Chromatin immunoprecipitation coupled to Sequencing (ChiP-Seq).
• Cell surface proteomics by Mass Spectrometry.
• Seahorse bioenergetic analyses.
• Primary hepatocyte and adipocyte cell culture.
• Automated indirect calorimetric interrogation of energy metabolism in mice.
• Bioinformatic data analysis and multi -OMICS data integration.
• CRISPR/Cas9 mediated gene activation and deletion.


Key collaborations:
Professor Madan Babu (MRC-LMB, Cambridge, United Kingdom, ADIPOSIGN partner)
Professor Blagoy Blagoyev (SDU, Odense, Denmark)
Professor Hildegard Büning (Medical School Hannover, Germany)
Professor Ivan G Costa (Centre for Medical Technology, Aachen, Germany)
Professor Nils J Færgeman (SDU, Odense, Denmark)
Professor Jörg Heeren (University Clinic Hamburg-Eppendorf, Germany)
Professor Ole Nørregård Jensen (SDU, Odense, Denmark)
Professor Susanne Mandrup (SDU, Odense, Denmark, ADIPOSIGN partner)
Professor Dagmar Wachten (University Clinic Bonn, Germany)
Professor Daniel Wüstner (SDU, Odense, Denmark)
Associate Professor Romain Barres (Center for Basic Metabolic Research, Copenhagen, Denmark)
Associate Professor Zach Gerhart-Hines (Center for Basic Metabolic Research, Copenhagen, Denmark, ADIPOSIGN partner)
Associate Professor Radek Sedlacek (Czech Center for Phenogenomics Prague, Czech Republic)
Assistant Professor Thomas A. Valim (UCLA, Los Angeles, USA)
Priv. Doz Dr. Martin Bilban (University Clinic, Vienna, Austria).
Dr. Haiming Cao (NIH/NHLB, Bethesda, USA)

 

You can read more about Jan-Wilhelm and his research at www.kornfeldlab.com