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Ming Ding

Professor
Department of Clinical Research, Orthopedics

Phone: +4565413598
Email: ming.ding@rsyd.dk
Webpage: Home page

The Orthopedic Research Unit web page

In vivo micro-CT and semi nano-CT scanners at the Orthopaedic Research Lab., Department of Orthopaedic Surgery & Traumatology, OUH, and the Department of Clinical Research, SDU

 

Contact person: Professor Ming Ding ming.ding(at)rsyd.dk

1. vivaCT 40 - Small animal in vivo preclinical micro-CT scanner

vivaCT 40 is a fast and flexible in-vivo microCT (micro-computed tomography) scanner for preclinical studies (SCANCO Medical AG, Switzerland). The low X-ray dose allows serial measurements of individuals. Whole-body scans or scans from selected regions of mice can be made, while head and hind limbs of larger rodents can be scanned using beds supplied with the system.

Specifications:

Type: Cone-beam in vivo microCT, Fully shielded

X-ray source: Sealed, Air-cooled, 30 - 70 kVp

Detector: 2048 x 256 elements, 26 µm pitch

Resolution: ‹ 14 µm (10% MTF), 5 - 76 µm nominal isotropic (pixel size)

Image matrix: 512 x 512 to 4096 x 4096 pix

Max. scan size: 38.9 x 145 mm (ØxL)

Max. specimen size: 80 x 500 mm (ØxL)

Electrical: 100 - 230 V / 50 - 60 Hz, 370 W

Location: Biomedicine Laboratory, SDU, J.B. Winsløws Vej 23, 5000 Odense C (shared with KMEB).

Figure 1: 3-D illustrations of micro-CT images of various bone tissues & biomaterials

Our research directions:

  1. Monitor changes in 3-D microarchitecture over times in mouse and rat in vivo.
  2. Quantify 3-D microarchitecture of bone tissues and biomaterials.
  3. Quantify bone damage and regeneration in e.g. osteoporosis & osteoarthritis etc.

2. Semi-nano-CT sample scanner

Semi-nano-CT50 combines submicron pixel size (nanoCT) with a large field-of-view, making this system extremely versatile (SCANCO Medical AG, Switzerland). The optional sample changer accommodates up to 12 sample holders, and a filter changer offering 4 different materials can be fitted. Variable filter and X-ray power settings greatly increase the range of materials that can be scanned.

Specifications:

Type: Cabinet cone-beam microCT Fully shielded

X-ray source: 5 - 30 µm spot size (4 - 18 W), 20 - 100 kVp (45, 55, 70, 90 kVp)

Detector: 3400 x 1200 elements, 20 µm pitch

Resolution: 0.5 µm (nanoCT) - 100 µm nominal isotropic (pixel size)

Image matrix: 512 x 512 to 8192 x 8192 pixels

Max. scan size: 50 x 120 mm (ØxL)

Max. specimen size: 100* x 160 mm (ØxL)

Electrical:     100 - 230 V / 50 - 60 Hz, max. 400 W

 

Location: Orthopaedic Research Laboratory, OUH J.B.Winsløws Vej 15, st. th. 5000 Odense C.

 

Figure 2: Semi-nano-CT with 3-D illustrations of the osteocyte lacunae (upper) and haversian canals (lower) of cortical bone

Our research directions:

  1. 3-D microarchitecture of trabecular bone and biomaterials.
  2. Morphometric parameters of rod and plate trabeculae
  3. Ultrastructure of cortical bone and biomaterials.
  4. Bone titanium implant interface.
  5. Soft tissue and blood vessel formation.
  6. Quantify bone damage and regeneration in e.g. osteoporosis & osteoarthritis etc.

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