Title
Professor
Department and Faculty
Department of Molecular Medicin, Faculty of Health Sciences
Funding
Novo Nordisk Foundation, Danish National Research Foundation, BRIDGE
Research vision
The research in Tiwari lab aims at achieving an integrated molecular and systems-level understanding of the communication between genetic and epigenetic information in determining cell identity and how this communication is altered in cancer and neurological disorders. To address these questions, his lab employs a multidisciplinary approach combining cutting-edge genomics and epigenetics together with computational biology tools in defined animal and cellular models and the observations are further validated in clinical samples.
Three key publications
A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development
Sahu SK, Agirre E, Inayatullah M, Mahesh A, Tiwari N, Lavin DP, Singh A, Strand S, Diken M, Luco RF, Belmonte JCI, Tiwari VK
Nat Cell Biol, 2022, 24(8):1265-1277
doi: 10.1038/s41556-022-00971-3.
Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition
Lavin DP, Abassi L, Inayatullah M, Tiwari VK
Molecular and Cellular Biology. 2021; 41(11):e0018321
doi: 10.1128/MCB.00183-21.
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P, Tiwari VK
Nature Commun, 2017; 15;8(1):1523.
doi: 10.1038/s41467-017-01366-x.
