Department and Faculty
Department of Biochemistry and Molecular Biology, Faculty of Science
Our cancer research programme is funded by the Danish Cancer Society and the Novo Nordisk foundation.
Our group is interested in the transcriptional and epigenetic mechanisms controlling progression of breast cancer. We use an integrated omics-approach involving both functional genomics and proteomics methods to investigate the molecular mechanisms controlling breast cancer growth, treatment responses and metastasis. In addition, we are interested in studying the dynamic interplay between cancer cells and the tumour microenvironment using single-cell technologies.
Three key publications
IL6 /STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis
Siersbæk R*, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D’Santos C, Zwart W, Russell A, Brisken C, Carroll JS*
Cancer Cell, 2020. 38(3):412-423.e9.
A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.
Papachristou EK, Kishore K, Holding AN, Harvey K, Roumeliotis TI, Chilamakuri CSR, Omarjee S, Chia KM, Swarbrick A, Lim E, Markowetz F, Eldridge M, Siersbæk R*, D'Santos CS*, Carroll JS*
Nat Commun., 2018, 9(1):2311.
Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
Siersbæk R*, Kumar S, Carroll JS*
Genes Dev., 2018, 32(17-18):1141-1154.