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Paolo Ceppi

Cancer metabolism

Phone: +45 6550 4880
Webpage: Paolo Ceppi

Associate Professor

Department and Faculty
Department of Biochemistry and Molecular Biology, Faculty of Science

Novo Nordisk (Hallas Møller Ascending Grant), Danish Cancer Society, Sygeforsikring “danmark”, Danmarks Frie Forskningsfond, Lundbeck, IASLC.

Research vision
The Ceppi lab focuses on the identification of novel fundamental mechanisms of cancer biology using several cell and molecular biology techniques, mouse models, high-throughput approaches and the analysis of human samples. We aim at discovering novel genes and molecular pathways that regulate the plasticity and the aggressiveness of cancer cells, with a special focus on metabolism. The final goal is the development of more effective drugs and therapeutic strategies.

Three key publications
Targeting EMT in Cancer with Repurposed Metabolic Inhibitors
Ramesh V, Brabletz T, Ceppi P.
Trends Cancer, 2020; 6(11):942-950
doi: 10.1016/j.trecan.2020.06.005.

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers
Siddiqui A, Gollavilli PN, Schwab A, Vazakidou ME, Ersan PG, Ramakrishnan M, Pluim D, Coggins S'A, Saatci O, Annaratone L, Schellens JHM, Kim B, Asangani IA, Rasheed SAK, Marchiò C, Sahin O, Ceppi P
Cell Death and Differentiation, 2019; 26(11):2223-2236
doi: 10.1038/s41418-019-0289-6.

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Schwab A, Siddiqui A, Vazakidou ME, Napoli F, Böttcher M, Menchicchi B, Raza U, Saatci Ö, Krebs AM, Ferrazzi F, Rapa I, Dettmer-Wilde K, Waldner MJ, Ekici AB, Rasheed SAK, Mougiakakos D, Oefner PJ, Sahin O, Volante M, Greten FR, Brabletz T, Ceppi P
Cancer Research, 2018; 78(7):1604-1618
doi: 10.1158/0008-5472.CAN-17-2834.