Department and Faculty
Department for Molecular Medicine, Faculty of Health Sciences
Region of Southern Denmark, Danish Cancer Society, The Novo Nordisk Foundation etc.
Aims of research:
1. Understand how epigenetic activation of genes, normally only expressed in male germ cells (i.e. cancer/testis antigens), support hallmark phenotypes of cancer cells.
2. Understand the complex interactions between cancer cells and immune cells in the tumor microenvironment and find novel ways to modulate these to enhance anti-tumor immunity.
Three key publications
DNA methyltransferase inhibition promotes recruitment of myeloid-derived suppressor cells to the tumor microenvironment through induction of tumor cell- intrinsic interleukin-1
Traynor S, Terp MG, Nielsen AY, Guldberg P, Jakobsen M, Pedersen PG, Gammelgaard OL, Pedersen CB, Pedersen MT, Rattenborg S, Ditzel HJ, Gjerstorff MF.
Cancer Lett. 2022 Oct 26:215982.
SSX addiction in melanoma propagates tumor growth and metastasis
Traynor S, Ebstrup ML, Gammelgaard O, Mansoori B, Terp MG, Rein CRH, Rattenborg S, Pedersen CB, Ditzel HJ and Gjerstorff MF.
Front Oncol. 2022 Oct 7;12:998000.
Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins
Traynor S, Møllegaard NE, Jørgensen MG, Brückmann NH, Pedersen CB, Terp MG, Johansen S, Dejardin J, Ditzel HJ, Gjerstorff MF.
Nucleic Acids Res. 2019 Jul 26;47(13):6668-6684.