Why do stem cells age and lose their ability to maintain and regenerate tissues?
People worldwide are living longer. A longer life brings new opportunities, yet the extent of these depends heavily on one component - health. Stem cells replace worn or damaged cells and maintain healthy tissues. As stem cells age, their function deteriorates, which contributes to age-related disorders.
Deeper understanding of the mechanisms involved in stem cells ageing is crucial not only for appreciation of the pathophysiology of aging, but also in future development of stem cell-based therapies to treat aging-associated disorders. My research focuses on uncovering molecular pathways and mechanisms underlying ageing of skeletal muscle stem cells and their impact on muscle tissue regeneration.
I use state-of-art phosphoproteomics and redox-proteomics technologies that have reached unprecedented sensitivity levels allowing us, for the first time, to work with very small amounts of isolated stem cells.