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GRADE

A PhD course offered by The Graduate Programme in Physical Activity & Musculoskeletal Health

Course content:
The course will focus on evidence synthesis applicable for Guideline panels, including performing systematic review, meta-analysis and generating evidence profiles. The GRADE methodology incorporates current evidence-based approaches to the appraisal and synthesis of evidence and to the formulation of clinical practice recommendations. The GRADE process begins with asking an explicit question, including specification of all important outcomes. After the evidence is collected and summarized, GRADE provides explicit criteria for rating the quality of evidence that include study design, risk of bias, imprecision, inconsistency, indirectness, magnitude of effect and small study bias.

 Aim:

After the course all students are expected to be able to support guideline panels through a systematic review methodology and analyzing existing evidence available within a specific health research area. Furthermore the students will be able to use Review Manager, and GRADE Profiler (GRADEpro).

Form: 
The course venue will be The University of Southern Denmark, in Odense. The course is structured as an interaction of lectures and practical workshops. The lectures are followed by workshops, illustrating the type of exercise interventions addressed in the lecture. Lectures and workshops are in English. 

Course director: Assistant professor Carsten Bogh Juhl

ECTS-credits: 3,4

Max number of participants: 24

Course material: Handouts, published papers.

Course fee
The course is free of charge for PhD students enrolled at Universities that have joined the "Open market agreement".
For other participants there is a course fee of DKK 8450,-

If you have any questions, please contact:

Carsten Juhl, Ass. Prof. PhD and responsible for the course content: cjuhl@health.sdu.dk Phone: +45 2139 5639

Hans Lund, Professor and amanuensis for the course: hlund@health.sdu.dk Phone: +45 2572 11 25

 

 

Monday 16//2017

 

Basic principles of evidence synthesis

 

Tuesday 17/1/2015

 

GRADING the evidence – Development of the GRADE

Wednesday 18/1/2016

 

Performing and presenting evidence profile

9.00–10.30

Lecture:

 

Carsten Juhl (SDU)

 

Introduction to evidence synthesis – systematic review, meta-analysis and clinical guidelines. How to get hold of the evidence (ref. 1-4, 11)

 

Lecture:

 

Carsten Juhl (SDU)

 

Levels of evidence. Evaluating the quality of a systematic review. Grading the evidence. Downgrading and upgrading (6-10)

Lecture:

 

Julie Bolvig (Parker)

 

Evidence profile – How to create an evidence profile using GRADE profile and Revman (review manager)(5, 15)

10.45–12.15

Lecture:

 

Carsten Juhl (SDU)

 

Development of GRADE – Implementing GRADE –How to use GRADE - the advantage of using GRADE (5-10, 15)

 

Workshop (2 tutors)

 

Julie Bolvig (Parker) / Carsten Juhl (SDU)

 

Levels of evidence. Grading the evidence of a systematic review. Dovngrading and upgrading the evidence (12)

 

Workshop (2 tutors)

 

Julie Bolvig (Parker) / Carsten Juhl (SDU)

 

Evidence profile – How to create an evidence profile using GRADE profiler (12)

 

 

12.15–13-00

 

LUNCH

 

13.00-14.15

Workshop (2 tutors)

 

Hans Lund (SDU) / Carsten Juhl (SDU)

 

Evaluating risk of bias, small study bias, imprecision, inconsistency, indirectness and magnitude of effect in a systematic review (12)

 

Lecture:

 

Hans Lund (SDU)

 

From review to guideline – formulating recommendation in a clinical guideline using the GRADE approach (13-15)

Workshop (2 tutors)

 

Julie Bolvig (Parker) / Carsten Juhl (SDU)

 

Evidence profile – How to create an evidence profile using GRADE profiler (12)

 

14.30–15.30

Workshop (2 tutors)

 

Hans Lund (SDU) / Carsten Juhl (SDU)

 

Evaluating risk of bias, small study bias, imprecision, inconsistency, indirectness and magnitude of effect in a systematic review (12)

 

Workshop (2 tutors)

 

Julie Bolvig (Parker) / Carsten Juhl (SDU)

 

Levels of evidence. Grading the evidence of a systematic review. Dovngrading and upgrading the evidence (12)

Workshop (2 tutors)

 

Julie Bolvig (Parker) / Carsten Juhl (SDU)

 

Evidence profile – How to create an evidence profile using GRADE profiler (12)

 

    1.  O’Connor C, Green S, Higgins JPT (eds.). Defining the review question and developing criteria for including studies. Chapter 5 pp. 83-94, in Higgins JPT, Green S (eds.) Cochrane Handbook for Systematic Reviews of Interventions Cochrane Book Series, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England.
    2. Deeks JJ, Higgins JPT (eds.). Selecting studies and collecting data. Chapter 7 pp. 151- 185, in Higgins JPT, Green S (eds.) Cochrane Handbook for Systematic Reviews of Interventions Cochrane Book Series, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England.
    3. Deeks JJ, Higgins JPT, Altman DG on behalf of the Cochrane Statistical Methods Group (eds.). Analysing data and undertaking meta-analyses. Chapter 9 pp. 243-296, in Higgins JPT, Green S (eds.) Cochrane Handbook for Systematic Reviews of Interventions Cochrane Book Series, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England.
    4. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, Jaeschke R, Rind D, Meerpohl J, Dahm P, Schünemann HJ. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011 Apr;64(4):383-94.
    5. Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, Norris SL, Williams JW Jr, Atkins D, Meerpohl J, Schünemann HJ. GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias). J Clin Epidemiol. 2011 Apr;64(4):407-15.
    6. Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ,  Montori VM, Freyschuss B, Vist G, Jaeschke R, Williams JW Jr, Murad MH, Sinclair  D, Falck-Ytter Y, Meerpohl J, Whittington C, Thorlund K, Andrews J, Schünemann HJ. GRADE guidelines 6. Rating the quality of evidence -imprecision. J Clin Epidemiol. 2011;64(12):1283-93. 
    7. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, Norris S, Vist G, Dahm P, Shukla VK, Higgins J, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. GRADE guidelines: 7. Rating the quality of evidence -inconsistency. J Clin Epidemiol. 2011;64(12):1294-302. 
    8. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, Akl EA, Post PN, Norris S, Meerpohl J, Shukla  VK, Nasser M, Schünemann HJ; GRADE Working Group. GRADE guidelines: 8. Rating the quality of evidence -indirectness. J Clin Epidemiol 2011;64(12):1303-10.
    9. Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, Alonso-Coello P, Djulbegovic B, Atkins D, Falck-Ytter Y, Williams JW Jr, Meerpohl J, Norris SL, Akl EA, Schünemann HJ. GRADE guidelines: 5. Rating the quality of evidence -publication bias. J Clin Epidemiol. 2011;64(12):1277-82.
    10. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009 Oct;62(10):e1-34.
    11. Puhan MA, Gimeno-Santos E, Scharplatz M, Troosters T, Walters EH, Steurer J. Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2011 Oct 5;(10):CD005305.
    12. Andrews J, Guyatt G, Oxman AD, Alderson P, Dahm P, Falck-Ytter Y, Nasser M, Meerpohl J, Post PN, Kunz R, Brozek J, Vist G, Rind D, Akl EA, Schünemann HJ. GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol. 2013 Jul;66(7):719-25.
    13. Christensen R, Singh JA, Wells GA, Tugwell PS. Do "Evidence-Based Recommendations" Need to Reveal the Evidence? Minimal Criteria Supporting an "Evidence Claim". J Rheumatol. 2015 Oct;42(10):1737-9.
    14. Schünemann H, Brożek J, Guyatt G, Oxman A, editors. GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013. The GRADE Working Group, 2013. Available from www.guidelinedevelopment.org/handbook.

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