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Muscle pathology group

Group name
Muscle Group

Group leader
Henrik Daa Schrøder  professor MD, DMSc

Group description
The group includes students and researchers from medicine, science and sports.

Introduction to research area
The group deals with aspects of muscle biology.
Two major fields are focused on:
Muscle stem cell transplantation. The group works with aspects of preparation of cell material for transplantation, delivery and distribution in muscle tissue including use of scaffolds and application of supporting, bioactive compounds, and basic biology of the muscle stem cell niche.
Idiopathic inflammatory myopathies. The group is working in the field of digital pathology with development of tools to automatized quantitation of inflammatory events and application of these to describe types and activity in muscle from this group of patients. More over the tools are applied to studies on effects of treatments, in first line physical training.

Aim
The aim of our research in the field of regenerative medicine is to develop muscle derived cell transplantation as a treatment of striated sphincter muscles, to restore these in patients with incontinence.
The aim of research on Idiopathic inflammatory myopathies is to obtain a more objective and standardized way to characterize inflammatory myopathies in order to be able to better identify the subtypes and record changes following treatment

Research topics
Delivery of myogenic cells by use of hydrogels
Animal Models for sphincter treatment
Expression profile of interstitial cells in skeletal muscle
Validation of automized cell counts in Idiopathic inflammatory myopathies
Composition of inflamatory infiltrates in Idiopathic inflammatory myopathies

Methods
Cell culturing
Animal models and surgical techniques
Molecular biology
Immunohistochemistry including multiple labeling
Digital pathology

Last Updated 09.11.2020