Skip to main content

Publications 2020

20. Heidtmann, Christoffer V.; Voukia, Faidra; Hansen, Louise N.; Sørensen, Stine H.; Urlund, Brian; Nielsen, Salli; Pedersen, Mona; Kelawi, Noor; Andersen, Brian N.; Pedersen, Maria; Reinholdt, Peter; Kongsted, Jacob; Nielsen, Carsten U.; Klitgaard, Janne K.; Nielsen, Poul. Discovery of a potent adenine-benzyltriazolo-pleuromutilin conjugate with pronounced antibacterial activity against MRSA. Journal of Medicinal Chemistry (2020), 63(24), 15693-15708. [Abstract]

19. Omer, Marjan; Andersen, Veronica Liv; Nielsen, Jesper Sejrup; Wengel, Jesper; Kjems, Jørgen. Improved cancer targeting by multimerizing aptamers on nanoscaffolds. Molecular Therapy - Nucleic Acids (2020), 22, 994-1003. [Open Access]

 

18. El-Saidi, Manal Mohamed Talaat, El-Sayed, Ahmed Ali, Pedersen, Erik Bjerregaard, Tantawy, Mohamed Abdelhamid, Mohamed, Nadia Ragab, Gad, Wafaa Ahmed. Synthesis, characterization and docking study of novel pyrimidine derivatives as anticancer agents. Indonesian Journal of Chemistry (2020), 20, 1163-1177. [Abstract]

 

17. Beck, Kasper M.; Krogh, Marie B.; Hornum, Mick; Ludford, Paul T.; Tor, Yitzhak; Nielsen, Poul. Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition. Organic & Biomolecular Chemistry (2020), 18, 7213–7223. [Abstract]

 

 

16. Carreras-Badosa, Gemma; Maslovskaja, Julia; Periyasamy, Kapilraj; Urgard, Egon; Padari, Kart; Vaher, Helen; Tserel, Liina; Gestin, Maxime; Kisand, Kai; Arukuusk, Piret; Lou, Chenguang; Langel, Ulo; Wengel, Jesper; Pooga, Margus; Rebane, Ana. NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation. Biomaterials (2020), 262, 120316. [Abstract]

 

15. Gouda, Alaa S.; Przypis, Lukasz; Walczak, Krzysztof; Jørgensen Per T.; Wengel, Jesper. Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties. Organic & Biomolecular Chemistry(2020), 18, 6935-6948. [Abstract]

 

 

14. Fatthalla, Maha I.; Pedersen, Erik B. Evaluation of the base‐pairing properties of 5‐(5‐indolylethynyl) and 5‐(5‐indolyl)‐2′‐deoxyuridine modified triplex and duplex. ChemistrySelect (2020), 5, 10067–10071. [Abstract]

 

13. Cai, Yunpeng; Lou, Chenguang; Wengel, Jesper; Howard, Kenneth A. Albumin-binding fatty acid–modified gapmer antisense oligonucleotides for modulation of pharmacokinetics. Book chapter in: Yokota T., Maruyama R. (eds), Gapmers. Methods in Molecular Biology (Humana, New York, NY) (2020), 2176, 163-174. [Abstract]

 

12. Cinque, Giorgio; Ferino, Annalisa; Pedersen, Erik B.; Xodo, Luigi E. Role of poly [ADP-ribose] polymerase 1 in activating the Kirsten ras (KRAS) gene in response to oxidative stress. International Journal of Molecular Sciences(2020), 21, 6237. [Open Access].

11. Matta, Akanksha; Sharma, Ajendra Kumar; Tomar, Shilpi; Cao, Pei; Kumar, Sandeep; Balwani, Sakshi; Ghosh, Balaram; Prasad, Ashok K.; Van der Eycken, Erik V.; DePass, Antony L.; Wengel, Jesper; Parmar, Virinder S.; Len, Christophe; Singh, Brajendra Kumar. Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives. New Journal of Chemistry (2020), 44, 13716-13727. [Abstract]

 

10. Arias-Alpizar, Gabriela; Kong, Li; Vlieg, Redmar C; Rabe, Alexander; Papadopoulou, Panagiota; Meijer, Michael S; Bonnet, Sylvestre; Vogel, Stefan; van Noort, John; Kros, Alexander; Campbell, Frederick. Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo. Nature Communications (2020), 11, 3638.[Open Access]

9. Zeng, Dongdong; Salvatore, Princia; Karlsen, Kasper K.; Zhang, Jingdong; Wengel, Jesper; Ulstrup, Jens. Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces. Journal of Electroanalytical Chemistry (2020) 865, 114138. [Abstract]

8.Lou Chenguang; Boesen Josephine Tuborg; Christensen Niels Johan; Sørensen Kasper K; Jensen Knud Jørgen; Thulstrup Peter Waaben; Pedersen Martin Nors; Giralt Ernest; Wengel Jesper. Self-assembly of DNA-peptide supermolecules: Coiled-coil peptide structures templated by D-DNA and L-DNA triplexes exhibit chirality-independent but orientation-dependent stabilizing cooperativity. Chemistry - A European Journal (2020), 26(25), 5676-5684. [Abstract]

 

 

7. Abdelrahman, Asmaa; Gouda, Alaa S.; Jørgensen, Per T.; Wengel, Jesper. Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers. Nucleosides, Nucleotides & Nucleic Acids (2020), 39(1-3), 82-96. [Abstract]

 

6. Raguraman, Prithi; Wang, Tao; Ma, Lixia; Jørgensen, Per T.; Wengel, Jesper; Veedu, Rakesh N. Alpha-L-locked nucleic acid-modified antisense oligonucleotides induce efficient splice modulation in vitro. International Journal of Molecular Sciences(2020) 21(7), 2434. [Abstract]

 

5. Christou, Melina; Wengel, Jesper; Sokratous, Kleitos; Kyriacou, Kyriacos; Nikolaou, Georgios; Phylactou, Leonidas A.; Mastroyiannopoulos, Nikolaos P. Systemic evaluation of chimeric LNA/2’O-methyl steric blockers for Myotonic Dystrophy type 1 therapy. Nucleic acid therapeutics. (2019), 30(2), 80-93 [Abstract

 

4. Löffler, Philipp M. G.; Rabe, Alexander; Vogel, Stefan. Lipid-modified peptide nucleic acids: Synthesis and application to programmable liposome fusion. Book chapter in: Peter E. Nielsen (ed.), Peptide Nucleic Acids: Methods and Protocols. Methods in Molecular Biology (Clifton, N.J.) (2020), 2105, 75-96. [Abstract]

 

3. Danielsen, Mathias B.; Lou, Chenguang; Lisowiec-Wachnicka, Jolanta; Pasternak, Anna; Jørgensen, Per T.; Wengel, Jesper.Gapmer antisense oligonucleotides containing 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-D-lyxofuranosyl nucleotides display site-Specific RNase H cleavage and induce gene silencing. Chemistry - A European Journal (2020), 26(6), 1368-1379. [Abstract]

 

2. Löffler, Philipp M. G.; Ries, Oliver; Vogel, Stefan. DNA-Mediated liposome fusion observed by fluorescence spectrometry. Book chapter in: Astakhova K., Bukhari S. (eds) Nucleic Acid Detection and Structural Investigations. Methods in Molecular Biology (Clifton, N.J.) (2020), 2063, 101-118. [Abstract]

1. Duschmale, Jörg; Bleicher, Konrad; Hansen, Henrik Frydenlund; Albaek, Nanna; Møller, Marianne Ravn; Jensen, Klaus; Koch, Troels; Duschmale, Martina; Koller, Erich; Wengel, Jesper; Konrad, Bleicher. In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages. Nucleic Acids Research (2020), 48(1), 63-74. [Open Access]