Publications 2013

Andersen, Nicolai K.; Anderson, Brooke A.; Wengel, Jesper; Hrdlicka, Patrick J. Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-l-LNA adenine monomers: High-affinity targeting of single-stranded DNA. Journal of Organic Chemistry (2013), 78(24), 12690-12702. [Abstract]

Olsen; Birgitte Brinkmann; Thisgaard, Helge; Vogel, Stefan; Thomassen, Mads; Kruse, Torben A.; Needham, David; Mollenhauer, Jan; Høilund-Carlsen, Poul Flemming. Novel radioisotope-based nanomedical approaches. European Journal of Nanomedicine (2013), 5(4), 181–193. [Abstract]

Rasmussen, Thomas E.; Jauffred, Liselotte; Brewer, Jonathan; Vogel, Stefan; Torbensen, Esben R.; Lagerholm, B. Christoffer; Oddershede, Lene; Arnspang, Eva C. Single molecule applications of quantum dots. Journal of Modern Physics (2013), 4, 27-42. [Open Access]

Kumar, Pawan; Madsen, Charlotte S.; Nielsen, Poul. Synthesis of 2'-O-(thymin-1-yl)methyluridine and its incorporation into secondary nucleic acid structures. Bioorganic & Medicinal Chemistry Letters (2013), 14(9), 1072-1074. [Abstract]

Fontenete, Sílvia; Guimarães, Nuno; Leite, Marina; Figueiredo, Céu; Wengel, Jesper; Azevedo, Nuno Filipe. Hybridization based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes. PLoS ONE (2013), 8(11), e81230. [Open Access]

Kosbar, Tamer; Sofan, Mamdouh; Abou-Zeid, Laila; Waly, Mohamed; Pedersen, Erik B. Highly efficient synthesis of allopurinol locked nucleic acid monomer by C6 deamination of 8-aza-7-bromo-7-deazaadenine locked nucleic acid monomer. Synthesis (2013), 45(23), 3259–3262. [Abstract]

Xu, Liang; Plouffe, Steven W.; Chong, Jenny; Wengel, Jesper; Wang, Dong. A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids. Angewandte Chemie International Edition, 2013, 39, 12341 –12345 [Abstract] – Hot paper.

Marusic, Maja; Veedu, Rakesh N.; Wengel, Jesper; Plavec, Janez. G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold. Nucleic Acids Research (2013), 41(20), 9524–9536. [Abstract]

Jørgensen, Anna S.; Gupta, Pankaj; Wengel, Jesper; Astakhova, I. Kira. “Clickable” LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies. Chemical Communications (2013), 49(91), 10751-10753. [Abstract]

Sau, Sujay P.; Madsen, Andreas S.; Podbevsek, Peter; Andersen, Nicolai K.; Kumar, T. Santhosh; Andersen, Sanne; Rathje, Rie L.; Anderson, Brooke A.; Guenther, Dale C.; Karmakar, Saswata; Kumar, Pawan; Plavec, Janez; Wengel, Jesper; Hrdlicka, Patrick J. Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA. Journal of Organic Chemistry (2013), 78(19), 9560-9570. [Abstract]

Karlsen, Kasper K.; Okholm, Anders; Kjems, Joergen; Wengel, Jesper. A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid). Bioorganic & Medicinal Chemistry (2013), 21(20), 6186–6190. [Abstract]

Jakobsen, Ulla; Vogel, Stefan. Assembly of liposomes controlled by triple helix formation. Bioconjugate Chemistry, 24(9), 1485-1495. [Abstract]

Kumar, Pawan; Sharma, Pawan K.; Madsen, Charlotte S.; Petersen, Michael; Nielsen, Poul. The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone. ChemBioChem. (2013), 14(9), 1072-1074. [Abstract]

Madsen, Charlotte S.; Nielsen, Lise J.; Pedersen, Nikolai S.; Lauritsen, Anne; Nielsen, Poul. Double-headed nucleotides in DNA-zipper structures; base-base interactions and UV-induced cross-coupling in the minor groove. RSC Advances, (2013), 3(27), 10696-10706. [Abstract]

Lundin Karin E; Hojland Torben; Hansen Bo R; Persson Robert; Bramsen Jesper B; Kjems Jorgen; Koch Troels; Wengel Jesper; Smith C I Edvard. Biological activity and biotechnological aspects of locked nucleic acids. Advances in genetics (2013), 82, 47-107. [Abstract]

Attwater, James; Tagami, Shunsuke; Kimoto, Michiko; Butler, Kyle; Kool, Eric T.; Wengel, Jesper; Herdewijn, Piet; Hirao, Ichiro; Holliger, Philipp. Chemical fidelity of an RNA polymerase ribozyme. Chemical Science (2013), 4(7), 2804-2814.[Abstract]

Astakhova, I. Kira; Hansen, Lykke Haastrup; Vester, Birte; Jesper Wengel. Peptide–LNA oligonucleotide conjugates. Org. Biomol. Chem. (2013), 11(25), 4240-4249. [Abstract]

Hidalgo Laura; Hopkins Katie L; Gutierrez Belen; Ovejero Cristina M; Shukla Suruchi; Douthwaite Stephen; Prasad Kashi N; Woodford Neil; Gonzalez-Zorn Bruno. Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. Journal of Antimicrobial Chemotherapy (2013), 68(7), 1543-1550. [Abstract]

Cogoi, Susanna; Zorzet, Sonia; Rapozzi, Valentina; Geci, Imrich; Pedersen, Erik B.; Xodo, Luigi E. MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice. Nucleic Acids Research (2013), 41(7), 4049-4064. [Abstract]

Barbeyron, Renaud; Wengel, Jesper; Vasseur, Jean-Jacques; Smietana, Michael. Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3'-end ribonucleotidic strand. Monatshefte füer Chemie (2013), 144(4), 495-500. [Abstract]

Moreno, Pedro M. D.; Geny, Sylvain; Pabon, Y. Vladimir; Bergquist, Helen; Zaghloul, Eman M.; Rocha, Cristina S. J.; Oprea, Iulian I.; Bestas, Burcu; Andaloussi, Samir EL; Jørgensen, Per T.; Pedersen, Erik B.; Lundin, Karin E.; Zain, Rula; Wengel, Jesper; Smith, C. I. Edvard. Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA. Nucleic Acids Research (2013) 41(5): 3257-3273. [Abstract]

Osman, Amany M. A.; Pedersen, Erik B.; Bergman, Jan. Synthesis of a new intercalating nucleic acid 6H-indolo[2,3-b] quinoxaline oligonucleotides to improve thermal stability of Hoogsteen-type triplexes. Nucleosides, Nucleotides and Nucleic Acids (2013), 32(2), 98-108. [Abstract]

Astakhova, I. Kira; Pasternak, Karol; Campbell, Meghan A.; Gupta, Pankaj; Wengel, Jesper. A locked nucleic acid-based nanocrawler: Designed and reversible movement detected by multicolor fluorescence. Journal of the American Chemical Society (2013), 135(7), 2423-2426. [Abstract]

Astakhova, I. Kira; Wengel, Jesper. Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes. Chem. Eur. J. (2013), 19(3), 1112-1122. [Abstract]

Astakhova, I. Kira; Santhosh Kumar, T.; Campbell, Meghan A.; Ustinov, Alexey V.; Korshun, Vladimir A.; Wengel, Jesper. Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2'-α-l-amino-LNA FRET pairs. Chemical Communications (2013), 49(5), 511-513. [Abstract]

Hansen, Allan G.; Salvatore, Princia; Karlsen, Kasper K.; Nichols, Richard J.; Wengel, Jesper; Ulstrup, Jens. Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces. Physical Chemistry Chemical Physics (2013), 15(3), 776-786. [Abstract]