Associate Professor Thomas Emil Andersen
Department of Clinical Microbiology, Odense University Hospital
Associate Professor Janne Kudsk Klitgaard
Department of Biochemistry and Molecular Biology
Staphylococcus aureus is able to form biofilms on implants or medical devices such as catheters, and from here disseminate to the blood and organs, which may result in life‐threatening infections such as endocarditis.
During the course of vascular spreading and formation of metastatic secondary site foci, the bacterium interacts with human immune effectors and coagulation components via its surface structures and secreted substances.
The mechanisms behind spreading and survival in the vascular system is largely unknown, especially how the bacterium escapes immune effectors and antibiotics in the process.
In this project doctors and molecular microbiologists from the Department of Clinical Microbiology, Odense University Hospital and the Department of Biochemistry and Molecular Biology, SDU, collaborate with the aim to elucidate the interactions between the S. aureus, the human inflammatory and coagulation system, and endothelial cells lining the vascular system and the heart.
Knowing more about these processes will allows us to better prevent and treat patients with difficult S. aureus bloodstream infections.
S. aureus (red)) invading endothelial cells
- The Region of Southern Denmark
- The Danish 3R center