Research aim: Our objective is to assess and apply biochemical markers for early prediction and improved risk stratification and diagnosis of major pregnancy complications such as gestational diabetes and preeclampsia and for breaking the vicious cycle of obesity and diabetes. Additionally, we seek to leverage multi-omics approaches to achieve deep phenotyping of molecular alterations associated with hyperglycemia in placental and umbilical cord vasculature.
Projects
- Multi-omics -based deep phenotyping of molecular alterations associated with hyperglycemia in placental and umbilical cord vasculature (GDMB project)
- Development of a risk engine for prediction of gestational diabetes and adverse pregnancy outcomes in the prospective cohorts SugarMum and Odense Child Cohort
- Identifying Cardiometabolic Risk Markers for Obesity-Related Diseases -Analysis of the South Danish Obesity Initiative Cohort
- Placental biomarkers for prediction of preeclampsia
- Implementation and retrospective performance of the ratio of angiogenic factors sFlt-1/PlGF in women with suspected preeclampsia
Available cohorts and infrastructures
- SugarMum (biobank wk 12, wk 24-28)
- Danish Diabetes Birth Registry 2 (DDBR2) (biobank wk 12, wk 24-28) (Prof. Dorte Møller Jensen)
- Odense GDM (biobank wk 8-12)
- PRESIDE-OUH (biobank wk 12)
- Odense Child Cohort (Prof. Marianne Skovsager Andersen)
Collaborators
- Steno Diabetes Center Odense, OUH - Dorte Møller Jensen, Kurt Højlund Thomas Bastholm Olesen, Claus Bogh Juul
- Department of Obstetrics and Gynecology, OUH - Christina Vinter, Lene Sperling Lise Lotte Torvin Andersen
- Department of Endocrinology, OUH - Dorte Glintborg, Louise Lehmann Christensen, Marianne Skovsager Andersen
- SDU - Lasse Bach Steffensen, Nils Færgeman, Richard Röttger
- External and international - Line Rode, Iben Riishede, Charlotte Ekelund, Caroline Lilliecreutz, Gernot Desoye, David McIntyre
Selected publications
- Bastiansen SO, Nielsen TM, Rode L, Lynggaard R, Vinholt PJ, Sperling L, Vinter CA, Jensen DM, Andersen LLT, Overgaard M. Diabetes in pregnancy attenuates the sFlt-1/PlGF ratio for prediction of preeclampsia. Pregnancy Hypertens. 2026 Feb 17;43:101430.
- Faarvang AA, Overgaard M, Jensen PS, Riber LPS, Wod M, Steffensen LB, Rasmussen LM. Arterial collagen IV and laminin levels associate with type 2 diabetes, glycemic control, major adverse cardiac events, and mortality in coronary bypass patients. Cardiovasc Diabetol. 2025 Dec 17;24(1):458.
- Hallig SJ, Aalders J, Christensen MH, Andersen MS, Vinter CA, Dunne F, Højlund K, Jensen DM, Overgaard M. (2025) The cardio-metabolic protein profile is associated with development of type 2 diabetes at long term follow-up after gestational diabetes mellitus: Results from the OGFUS study. Diabetes Obes Metab. 2025 Mar;27(3):1456-1465.
- Faurø KK, Obel LM, Christesen HT, Jensen DM, Jensen TK, Glintborg D, Andersen MS, Overgaard M. (2025) Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort. Endocr Pract. 17:S1530-891X(25)00049-7.
- Riishede I, Rode L, Sperling L, Overgaard M, Ravn JD, Sandager P, Skov H, Wagner SR, Norgaard P, Clausen TD, Jensen CAJ, Pihl K, Jorgensen FS, Munk JK, Zingenberg HJ, Pedersen NG, Andersen MR, Wright A, Wright D, Tabor A, Ekelund CK. Pre-eclampsia screening in denmark (preside): National validation study. Ultrasound Obstet Gynecol. 2023;61:682-690.
- Andersen LLT, Helt A, Sperling L, Overgaard M Decision Threshold for Kryptor sFlt‐1/PlGF Ratio in Women With Suspected Preeclampsia: Retrospective Study in a Routine Clinical Setting,J Am Heart Assoc (2021) Sep 7;10(17).
- Ravnsborg T, Svaneklink S, Andersen LLT, Larsen MR, Jensen DM, Overgaard M. First-trimester proteomic profiling identifies novel predictors of gestational diabetes mellitus. PLoS One (2019) Mar 27;14(3).