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Molekylær Epidemiologi: Udvalgte publikationer

On the power of epigenome-wide association studies using a disease-discordant twin design.
Li W, Christiansen L, Hjelmborg J, Baumbach J, Tan Q.
Bioinformatics. 2018 Jun. [Epub ahead of print] Pubmed abstract

 Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.

Mengel-From J, Feddersen S, Halekoh U, Heegaard NHH, McGue M, Christensen K, Tan Q, Christiansen L.

Eur J Hum Genet. 2018 May. [Epub ahead of print] Pubmed abstract

 

2017

Identification and characterization of two functional variants in the human longevity gene FOXO3.

Flachsbart F, Dose J, Gentschew L, Geismann C, Caliebe A, Knecht C, Nygaard M, Badarinarayan N, ElSharawy A, May S, Luzius A, Torres GG, Jentzsch M, Forster M, Häsler R, Pallauf K, Lieb W, Derbois C, Galan P, Drichel D, Arlt A, Till A, Krause-Kyora B, Rimbach G, Blanché H, Deleuze JF, Christiansen L, Christensen K, Nothnagel M, Rosenstiel P, Schreiber S, Franke A, Sebens S, Nebel A.

Nat Commun. 2017 Dec;8(1):2063. Pubmed abstract

 

Disease-Concordant Twins Empower Genetic Association Studies.

Tan Q, Li W, Vandin F.

Ann Hum Genet. 2017 Jan;81(1):20-26. Pubmed abstract

 

2016

DNA methylation age is associated with mortality in a longitudinal Danish twin study.

Christiansen L, Lenart A, Tan Q, Vaupel JW, Aviv A, McGue M, Christensen K.

Aging Cell. 2016 Feb;15(1):149-54. Pubmed abstract

 

Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group.

Mengel-From J, Soerensen M, Nygaard M, McGue M, Christensen K, Christiansen L.

J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1151-9. Pubmed abstract

 

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment.

Nygaard M, Debrabant B, Tan Q, Deelen J, Andersen-Ranberg K, de Craen AJ, Beekman M, Jeune B, Slagboom PE, Christensen K, Christiansen L.

Aging Cell. 2016 Feb;15(1):49-55. Pubmed abstract

 

No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.

Soerensen M, Nygaard M, Debrabant B, Mengel-From J, Dato S, Thinggaard M, Christensen K, Christiansen L.

Exp Gerontol. 2016 Jun;78:57-61. Pubmed abstract

 

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

Tan Q, Heijmans BT, Hjelmborg JV, Soerensen M, Christensen K, Christiansen L.

Int J Epidemiol. 2016 Aug;45(4):1146-1158. Pubmed abstract

 

2014

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly.

Mengel-From J, Thinggaard M, Dalgård C, Kyvik KO, Christensen K, Christiansen L.

Hum Genet. 2014 Sep;133(9):1149-59. Pubmed abstract

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