Associate Professor, Ph.D.
Department of Neurobiology Research
Phone: +45 6550 3802
Mobile: +45 2513 8637
Projects targeted at students
The Stem Cell and developmental neurobiology Group is a subgroup within a larger, internationally recognized research unit, with strong international and industrial relations, focusing on injury, protection and repair of CNS nerve cells and glial cells using in vitro and animal models of disease.
The stem cell and developmental neurobiology research program is focused on identifying molecular and biochemical signals regulating cell fate decisions. We place particular emphasis on formation of functional dopaminergic neurons with midbrain identity - the cell type that degenerates in Parkinson’s disease.
Using stem cells derived from developing human brain tissue (neural stem cells) and patients with Parkinson’s disease (induced pluripotent stem cells), we pursue investigating the following topics:
- influence of oxygen on stem cell differentiation
- effect of carbon monoxide on cell fate and neuronal survival
- fate of stem cells exposed to levodopa (therapeutic drug, dopamine precursor)
- interaction between stem cells and microglia secreted factors
- the pathogenesis of Parkinson’s disease by molecular and functional characterization of dopaminergic neurons produced from patient-derived pluripotent stem cells
Our general ambitions are to advance the understanding of the molecular mechanisms underlying Parkinson’s disease and to contribute to the development of a potential future stem cell therapy.
To achieve our goals we use cell cultures and animal models of Parkinson’s disease. Our methods include biochemical/molecular assays (e.g. Western blotting, enzyme assays, HPLC analysis), stereotactic cell transplantation, behavioural analyses (motor assessment) and histological techniques (e.g. cytochemistry, immunocytochemistry).
Krabbe C, Thornby Bak S, Linstow CU, Jensen P, Martinez-Serrano A, Hansen C, Meyer M. (2014). Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin (PLoS ONE 9(5): e96465. doi:10.1371/journal.pone.0096465).
Erichsen JL, Blaabjerg M, Bogetofte H., Martinez Serrano A, Meyer M. (2015). Group I Metabotropic Glutamate Receptors: A Potential Target for Regulation of Proliferation and Differentiation of an Immortalized Human Neural Stem Cell Line (Basic & Clinical Pharmacology & Toxicology, 116, 4, 329-336).
Liechti R, Ducray AD, Jensen P, Di Santo S, Seiler S, Jensen CH, Meyer M, Widmer HR. (2015). Characterization of Fetal Antigen 1/Delta-Like 1 Homologue Expressing Cells in the Rat Nigrostriatal System: Effects of a Unilateral 6-Hydroxydopamine Lesion (PLoS ONE: DOI: 10.1371/journal.pone.0116088).
Braga MNDM, Meyer M, Zeng X, Larsen, M R. (2015). Characterization of human neural differentiation from pluripotent stem cells using proteomics/PTMomics - current state-of-the-art and challenges (Proteomics. 15, 4, 656-674).
Halle B, Marcusson EG, Aaberg-Jessen C, Jensen SS, Meyer M, Schulz MK, Andersen C, Kristensen BW (2015).Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept(Journal of Neuro-Oncology, 10.1007/s11060-015-1947-2).
Jensen P, Ducray AD, Widmer HR, Meyer M (2015). Effects of Forskolin on Trefoil factor 1 expression in cultured ventral mesencephalic dopaminergic neurons (Neuroscience 310, 699-708).