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Louise Aarup Duus

Clinical outcome after nephron sparing treatment of renal cancer

Louise Aarup Duus, MD, PhD student

Surgery is the gold standard curable treatment of renal cancer. Minimally invasive nephron sparing treatments such as ablation (destruction of cancer cells with heat or cold) were developed approximately 15 years ago as a treatment option for comorbid patients that could not undergo surgery. Cryoablation has proved to be a good alternative to surgery.

Today, cryoablation is also offered patients that are otherwise healthy.

In this project we investigate clinical, oncological and kidney functional outcome in patients with renal cancer treated with partial nephrectomy or cryoablation.

The project includes four studies:

  1. A retrospective study of oncological outcome and complications after CT-guided cryoablation of renal cancer performed in 2012-2017 at Odense University Hospital.
  2. A retrospective study of renal functional outcome after CT-guided cryoablation of renal tumors performed in 2014-2018 at Odense University Hospital.
  3. Systematic literature review of renal functional outcome after minimally invasive partial nephrectomy or CT-guided cryoablation of renal cancer.
  4. A prospective cohort study of renal functional outcome in patients with renal cancer treated with minimally invasive partial nephrectomy or cryoablatiton. Renal function is investigated with DTPA clearance and renography before and 6 months after treatment.

Main supervisor:

Ole Graumann, Associate Professor, MD, PhD

Co-supervisors:

Benjamin S Rasmussen, MD, PhD, Post Doc

Lars Lund, Professor, MD, DMSc

Michael Petersen, Professor, MSc, PhD

Time span:

2018-2021

 

Sidst opdateret: 07.02.2020