RNA Drugs and Targets
NAC Center Seminar 60
Department of Chemistry and Applied Biosciences
Institute of Pharmaceutical Sciences, ETH Zürich
Research at the Institute of Pharmaceutical Sciences at the ETH is guided by the mission statement: "Targets - therapeutics - diagnostics: From concepts to prototypes“. The long-term objective of our Group is to demonstrate the drugability of RNA. RNA is considered undrugable with small compounds in the pharmaceutical industry because it is difficult to identify molecules that bind RNAs with sufficient affinity and selectivity. Furthermore, clinically-important RNA targets for diseases are probably very rare. Single-stranded oligoribonucleotides bind to RNAs with tight affinity and phenomenal selectivity but they have very poor pharmacokinetics properties and are difficult to develop as drugs. Recent data representing some of the efforts to address these challenges will be presented and discussed.
31.07.2012Back to the news list