Nielsen, Poul; Wengel, Jesper. Locked nucleic acids: properties, applications, and perspectives. Modified Nucleosides (2008), 133-152.
Pedersen, Erik Bjerregaard; Van Daele, Ineke; Filichev, Vyachelsav V.; Bomholt, Niels. Hoogsteen-type triplex formation of pyrene labeled probes for nucleic acid detection in fluorescence assay. PCT Int. Appl. (2008), 52pp, WO2008067825. [Abstract]
Wengel, Jesper. Hydroxymethyl substituted RNA oligonucleotides and RNA complexes. PCT Int. Appl. (2008), 92 pp, WO2008147824. [Abstract]
Kumar, Niti; Patowary, Ashok; Sivasubbu, Sridhar; Petersen, Michael; Maiti, Souvik. Silencing c-MYC expression by targeting quadruplex in P1 promoter using locked nucleic acid trap. Biochemistry (2008), 47(50), 13179-13188. [Abstract]
Irina V. Astakhova, Vladimir A. Korshun, Jesper Wengel. Highly fluorescent conjugated pyrenes in nucleic acid probes: (Phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids. Chem. Eur. J. (2008), 14, 11010-11026. [Abstract]
Filichev, Vyacheslav V.; Astakhova, Irina V.; Malakhov, Andrei D.; Korshun, Vladimir A.; Pedersen, Erik B. 1-, 2-, and 4-Ethynylpyrenes in the structure of twisted intercalating nucleic acids: Structure, thermal stability, and fluorescence relationship. Chem. Eur. J. (2008), 14(32), 9968 – 9980. [Abstract]
Osman, Amany M. A.; Jørgensen, Per T.; Bomholt, Niels; Pedersen, Erik B. Using an aryl phenanthroimidazole moiety as a conjugated flexible intercalator to improve the hybridization efficiency of a triplex-forming oligonucleotide. Bioorganic & Medicinal Chemistry (2008), 16(23), 9937-9947. [Abstract]
Monshupanee Tanakarn; Gregory Steven T; Douthwaite Stephen; Chungjatupornchai Wipa; Dahlberg Albert E. Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications. Journal of bacteriology (2008), 190(23), 7754-7761. [Abstract]
Purta, Elzbieta; Kaminska, Katarzyna H.; Kasprzak, Joanna M.; Bujnicki, Janusz M.; Douthwaite, Stephen. YbeA is the m3Y methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA (2008), 14(10), 2234-2244. [Abstract]
Sunita, S.; Tkaczuk, Karolina L.; Purta, Elzbieta; Kasprzak, Joanna M.; Douthwaite, Stephen; Bujnicki, Janusz M.; Sivaraman, J. Crystal structure of the Escherichia coli 23S rRNA:m5C Methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. Journal of Molecular Biology (2008), 383(3), 652-666. [Abstract]
Purta, Elzbieta; O'Connor, Michelle; Bujnicki, Janusz M.; Douthwaite, Stephen. YccW is the m5C Methyltransferase specific for 23S rRNA nucleotide 1962. Journal of Molecular Biology (2008), 383(3), 641-651. [Abstract]
Astakhova, Irina V.; Korshun, Vladimir A.; Jahn, Kasper; Kjems, Jorgen; Wengel, Jesper. Perylene attached to 2'-amino-LNA: Synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture. Bioconjugate Chemistry (2008), 19(10), 1995-2007. [Abstract]
Bomholt, Niels; Osman, Amany M. A.; Pedersen, Erik B. High physiological thermal triplex stability optimization of twisted intercalating nucleic acids (TINA). Org. Biomol. Chem. (2008), 6(20), 3714-3722. [Abstract]
Andersen Charlotte; Sharma Pawan K; Christensen Mikkel S; Steffansen Signe I; Madsen Charlotte M; Nielsen Poul. Nucleic acid secondary structures containing the double-headed nucleoside 5'(S)-C-(2-(thymin-1-yl)ethyl)thymidine. Org. Biomol. Chem. (2008), 6(21), 3983-3988. [Abstract]
Kumar, T. Santhosh; Madsen, Andreas S.; Ostergaard, Michael E.; Wengel, Jesper; Hrdlicka, Patrick J. Nucleic acid structural engineering using pyrene-functionalized 2'-amino-α-L-LNA monomers and abasic sites. Journal of Organic Chemistry (2008), 73(18), 7060-7066. [Abstract]
Madsen Andreas Stahl; Langkjaer Niels; Wengel Jesper. Nucleosides with 1,4-dioxane as sugar moiety. Nucleic acids symposium series (2008), 52(1), 269-270. [Abstract]
Jensen Troels Bundgaard; Langkjaer Niels; Wengel Jesper. Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies. Nucleic acids symposium series (2008), 52(1), 133-34. [Abstract]
Kaur Harleen; Arora Amit; Wengel Jesper; Maiti Souvik. Thermodynamic, counterion and hydration effects for the incorporation of locked nucleic acid (LNA) nucleotides in duplex. Nucleic acids symposium series (2008), 52(1), 425-426. [Abstract]
Arora Amit; Kaur Harleen; Wengel Jesper; Maiti Souvik. Effect of locked nucleic acid (LNA) modification on hybridization kinetics of DNA duplex. Nucleic acids symposium series (2008), 52(1), 417-418. [Abstract]
Singh Sunil K; Sharma Raman K; Maity Jyotirmoy; Wengel Jesper; Parmar Virinder S; Prasad Ashok K. Greener biocatalytic approach to the synthesis of nucleosides and their precursors. Nucleic acids symposium series (2008), 52(1), 273-274. [Abstract]
Hojland Torben; Babu B Ravindra; Wengel Jesper. New conformationally restricted DNA mimics. Nucleic acids symposium series (2008), 52(1), 271-272. [Abstract]
Andersen Charlotte; Sharma Pawan K; Christensen Mikkel S; Pedersen Nikolai S; Nielsen Poul. Synthesis of double-headed nucleosides with the additional nucleobase in the 5'-C-position. Nucleic acids symposium series (2008), 52(1), 275-276. [Abstract]
Andersen Nicolai K; Spacilova Lucie; Jensen Michael D; Kocalka Petr; Jensen Frank; Nielsen Poul. A click chemistry approach towards nucleic acid major groove functionalization. Nucleic acids symposium series (2008), 52(1), 149-150. [Abstract]
Sharma Pawan K; Enderlin Gerald; Kumar Surender; Nielsen Poul. Synthesis of 3'- and 6'-functionalized locked nucleic acid (LNA) analogues. Nucleic acids symposium series (2008), 52(1), 135-136. [Abstract]
Nielsen Poul; Shaikh Khalil I; Nielsen Lise J; Andersen Nicolai K; Spacilova Lucie; Nielsen Henrik; Kocalka Petr; Christensen Mikkel S. Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove. Nucleic acids symposium series (2008), 52(1), 5-6. [Abstract]
Pedersen Erik B; Osman Amany M A; Globisch Daniel; Paramasivam Manikandan; Cogoi Susanna; Bomholt Niels; Jorgensen Per T; Xodo Luigi E; Filichev Vyacheslav V. Triplex glue by synthesizing conjugated flexible intercalators. Nucleic acids symposium series (2008), 52(1), 37-38. [Abstract]
Filichev Vyacheslav V; Astakhova Irina V; Malakhov Andrei D; Korshun Vladimir A; Pedersen Erik B. DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids (TINAs), DNA duplexes/triplexes and interstrand excimer formation. Nucleic acids symposium series (2008), (52), 347-348. [Abstract]
Jakobsen Ulla; Simonsen Adam C; Vogel Stefan. DNA controlled assembly of soft nanoparticles. Nucleic acids symposium series (2008), 52(1), 225-226. [Abstract]
Jakobsen Ulla; Vogel Stefan. Lipophilic DNA-conjugates: DNA controlled assembly of liposomes. Nucleic acids symposium series (2008), 52(1), 223-224. [Abstract]
Jakobsen Ulla; Simonsen Adam C; Vogel Stefan. DNA controlled assembly of liposomes. Nucleic acids symposium series (2008), 52(1), 21-22. [Abstract]
Vogel, Stefan; Simonsen, Adam Cohen. Use of amphiphilic oligonucleotides to promote liposome formation on nucleic acid in the detection of amplification products. PCT Int. Appl. (2008), 67pp. WO 2008089771.
Lolk, Line; Pohlsgaard, Jacob; Jepsen, Anne Sofie; Hansen, Lykke H.; Nielsen, Henrik; Steffansen, Signe I.; Sparving, Laura; Nielsen, Annette B.; Vester, Birte; Nielsen, Poul. A click chemistry approach to Pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome. Journal of Medicinal Chemistry (2008), 51(16), 4957-4967. [Abstract]
Enderlin, Gerald; Nielsen, Poul. Synthesis of 6'-branched locked nucleic acid by a radical TEMPO-scavanged stereoselective mercury cyclization. Journal of Organic Chemistry (2008), 73(17), 6891-6894. [Abstract]
Dutkiewicz, Mariola; Grunert, Hans-Peter; Zeichhardt, Heinz; Lena, Suzy W.; Wengel, Jesper; Kurreck, Jens. Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3. FEBS Letters (2008), 582(20), 3061-3066. [Abstract]
Wengel, Jesper. Modified nucleic acids: Locked or unlocked? 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008), CARB-035.
Jakobsen, Ulla; Simonsen, Adam C.; Vogel, Stefan. DNA-Controlled assembly of soft nanoparticles. Journal of the American Chemical Society, (2008), 130(32), 10462-10463. [Abstract].
Wengel, Jesper. LNA (Locked Nucleic Acid) and functionalized LNA: toward efficient gene targeting. Chemistry and Molecular Aspects of Drug Design and Action (2008), 239-244.
Astakhova, Irina V.; Korshun, Vladimir A.; Wengel, Jesper. (Phenylethynyl)pyrenes attached to 2'-amino-LNA: novel fluorescent dyes with the advantages of long-wave emission, high fluorescence quantum yields and excimer formation. Collection Symposium Series (2008), 10 (Chemistry of Nucleic Acid Components), 491-495.
Astakhova, Irina V.; Korshun, Vladimir A.; Wengel, Jesper. Novel long-wave emission fluorochrome based upon perylen-3-ylcarbonyl-functionalized 2'-amino-LNA. Collection Symposium Series (2008), 10 (Chemistry of Nucleic Acid Components), 307-308.
Veedu, Rakesh N.; Vester, Birte; Wengel, Jesper. Enzymatic synthesis of LNA oligonucleotides using polymerases. Collection Symposium Series (2008), 10 (Chemistry of Nucleic Acid Components), 254-257.
Loksha, Yasser M.; Globisch, Daniel; Pedersen, Erik B.; La Colla, Paolo; Collu, Gabriella; Loddo, Roberta. Synthesis and anti-HIV-1 evaluation of 1,5-disubstituted pyrimidine-2,4-diones. Journal of Heterocyclic Chemistry (2008), 45(4), 1161-1166.
Veedu, Rakesh N.; Vester, Birte; Wengel, Jesper. Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates. Journal of the American Chemical Society (2008), 130(26), 8124-8125. [Abstract]
Paramasivam, Manikandan; Cogoi, Susanna; Filichev, Vyacheslav V.; Bomholt, Niels; Pedersen, Erik B.; Xodo, Luigi E. Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation. Nucleic Acids Research (2008), 36(10), 3494-3507. [Abstract]
Globisch, Daniel; Bomholt, Niels; Filichev, Vyacheslav V.; Pedersen, Erik B. Stability of Hoogsteen-type triplexes - electrostatic attraction between duplex backbone and triplex-forming oligonucleotide (TFO) using an intercalating conjugate. Helvetica Chimica Acta (2008), 91(5), 805-818. [Abstract]
Stanchev, Stancho; Momekov, Georgi; Jensen, Frank; Manolov, Ilia. Synthesis, computational study and cytotoxic activity of new 4-hydroxycoumarin derivatives. European Journal of Medicinal Chemistry (2008), 43(4), 694-706. [Abstract]
Kumar, T. Santhosh; Madsen, Andreas S.; Andersen, Nicolai K.; Wengel, Jesper; Hrdlicka, Patrick J. N2'-Functionalized 2'-amino-α-L-LNA: A novel class of locked nucleic acids as emerging tools for nucleic acid therapeutics and diagnostics. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008.
Østergaard, Michael E.; Maity, Jyotirmoy; Wengel, Jesper; Hrdlicka, Patrick J. 2'-N-(Pyren-1-yl)carbonyl-2'-amino-LNA (locked nucleic acid): A versatile label for nucleic acid detection. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008.
Guterstam, Peter; Lindgren, Maria; Johansson, Henrik; Tedebark, Ulf; Wengel, Jesper; El andaloussi, Samir; Langel, Uelo. Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers. Biochemical Journal (2008), 412(2), 307-313. [Abstract]
Dahl, Troels; Tornoee, Christian W.; Bang-Andersen, Benny; Nielsen, Poul; Joergensen, Morten. Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds. Angewandte Chemie, International Edition (2008), 47(9), 1726-1728. [Abstract]
Kalek, M., Benediktson, P., Vester, B. and Wengel, J. Identification of Efficient and Sequence Specific Bimolecular Artificial Ribonucleases by a Combinatorial Approach. Chem. Commun. (2008) 6, 762-764. [Abstract]
Douthwaite, S., Jakobsen, L., Yoshizawa, S. & Fourmy, D. Interaction of the tylosin-resistance methyltransferase RlmAII at its rRNA target differs from the orthologue RlmAI. J. Mol. Biol. (2008) 378, 969-975. [Abstract]
Van Daele Ineke; Bomholt Niels; Filichev Vyacheslav V; Van Calenbergh Serge; Pedersen Erik B. Triplex formation by pyrene-labelled probes for nucleic acid detection in fluorescence assays. ChemBioChem (2008), 9(5), 791-801. [Abstract]
Vester, Birte; Boel, Anne Marie; Lobedanz, Sune; Babu, B. Ravindra; Raunkjaer, Michael; Lindegaard, Dorthe; Raunak; Hrdlicka, Patrick J.; Hojland, Torben; Sharma, Pawan K.; Kumar, Surender; Nielsen, Poul; Wengel, Jesper. Chemically modified oligonucleotides with efficient RNase H response. Bioorganic & Medicinal Chemistry Letters (2008), 18(7), 2296-2300. [Abstract]
Wolter, N., Smith, A.M., Farrell, D.J., Northwood, J.B., Douthwaite, S. and Klugman, K.P. Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. Antimicrob. Agents Chemother. (2008), 52, 435-440. [Abstract]
Douthwaite, S., Jensen, R. L., and Kirpekar, F. The activity of rRNA resistance methyltransferases assessed by MALDI mass spectrometry. Methods in Mol. Medicine, (2008), vol. 142: New Antibiotic Targets (Ed.) W. S. Champney, Humana Press Inc. Totowa, NJ. 223-237.
Kaur, Harleen; Wengel, Jesper; Maiti, Souvik. Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA Strand. Biochemistry (2008), 47(4), 1218-1227. [Abstract]
Desnous, Celine; Babu, B. Ravindra; Moriou, Celine; Ortiz Mayo, Javier Ulises; Favre, Alain; Wengel, Jesper; Clivio, Pascale. The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level. Journal of the American Chemical Society (2008), 130(1), 30-31. [Abstract]
Danel, Krzysztof; Larsen, Louise M.; Pedersen, Erik B.; Sanna, Giuseppina; La Colla, Paolo; Loddo, Roberta. Synthesis and antiviral activity of new dimeric inhibitors against HIV-1. Bioorganic & Medicinal Chemistry (2008), 16(1), 511-517. [Abstract]
El-Brollosy Nasser R; Sorensen Esben R; Pedersen Erik B; Sanna Giuseppina; La Colla Paolo; Loddo Roberta. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs Emivirine and GCA-186. Archiv der Pharmazie (2008), 341(1), 9-19. [Abstract]
Christensen, Mikkel S.; Bond, Andrew D.; Nielsen, Poul. Synthetic nucleic acid secondary structures containing the four stereoisomers of 1,4-bis(thymine-1-yl)butane-2,3-diol. Organic & Biomolecular Chemistry (2008), 6(1), 81-91. [Abstract]
Lindegaard, D., Madsen, A. S., Astakhova, I. V., Malakhov, A. D., Babu, B. R., Korshun, V. A. and Wengel, J. Pyrene-perylene as a FRET pair coupled to the N2-functionaity of 2'-amino-LNA. Bioorg. Med. Chem. (2008) 94-99 [Abstract]