Andersen, Nicolai K.; Wengel, Jesper; Hrdlicka, Patrick J. N2'-Functionalized 2'-amino-α-L-LNA adenine derivatives - Efficient targeting of single stranded DNA. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1415-1417. [Abstract]
Højland, Torben; Babu, B. Ravindra; Bryld, Torsten; Wengel, Jesper. Triplex-forming ability of modified oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1411-1414. [Abstract]
Umemoto, Tadashi; Hrdlicka, Patrick J.; Babu, B. Ravindra; Wengel, Jesper. Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1261-1263. [Abstract]
Prasad, Ashok K.; Kalra, Neerja; Yadav, Yogesh; Singh, Sunil K.; Sharma, Sunil K.; Patkar, Shamkant; Lange, Lene; Olsen, Carl E.; Wengel, Jesper; Parmar, Virinder S. Selective biocatalytic deacylation studies on furanose triesters: A novel and efficient approach towards bicyclo-nucleosides. Organic & Biomolecular Chemistry (2007), 5(21), 3524-3530. [Abstract]
Bramsen, Jesper B.; Laursen, Maria B.; Damgaard, Christian K.; Lena, Suzy W.; Babu, B. Ravindra; Wengel, Jesper; Kjems, Jørgen. Improved silencing properties using small internally segmented interfering RNAs. Nucleic Acids Research (2007), 35(17), 5886-5897. [Abstract]
Wengel, Jesper; Kjems, Joergen. Small internally segmented interfering RNA (sisiRNA) for therapeutic use. PCT Int. Appl. (2007), 114 pp. WO 2007107162 A1.
Madsen, Andreas S.; Lindegaard, Dorthe; Astakhova, Irina V.; Malakhov, Andrei D.; Babu, B. Ravindra; Korshun, Vladimir A.; Wengel, Jesper. Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
Wengel, Jesper. LNA as a modification for siRNA designs and applications. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
Cogoi, Susanna; Paramasivan, Manikandan; Xodo, L. E.; Filichev, Vyacheslav V.; Pedersen, Erik B. The effect of INA [(R)-1-O-(1-Pyrenylmethyl)Glycerol] insertions on the structure and biological activity of a G-Quadruplex from a critical Kras G-Rich sequence. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1641-1643. [Abstract]
Loksha, Yasser M.; Pedersen, Erik B.; La Colla, Paolo; Loddo, Roberta. Synthesis of some novel 2,6-disubstituted pyridazin-3-ones as TMC120 analogues. Journal of Heterocyclic Chemistry (2007), 44(6), 1351-1356.
Andersen, Charlotte; Pedersen, Soren L.; Nielsen, Poul. Synthesis of nucleosides with additional nucleobases. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1435-1438. [Abstract]
Sharma, Pawan K.; Kumar, Surender; Nielsen, Poul. Synthesis of a branched locked nucleic acid (LNA) analogue. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1505-1508. [Abstract]
Albaek, Nanna; Petersen, Michael; Nielsen, Poul. Two carbocyclic locked nucleic acid analogues give structural information about the role of hydration in A-type duplexes. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1529-1532. [Abstract]
Sharma, Pawan K.; Nielsen, Poul; Bond, Andrew D. (1R,4R,7R,8R,9R)-8-Benzyloxy-7-benzyloxymethyl-2,5,10-trioxatricyclo[5.2.1.04,8]decan-9-ol. Acta Crystallographica, Section E: Structure Reports Online (2007), E63(12), o4537. [Abstract]
Sharma, Pawan K.; Kumar, Surender; Kumar, Pawan; Nielsen, Poul. Selective reduction of mono- and disubstituted olefins by NaBH4 and catalytic RuCl3. Tetrahedron Letters (2007), 48(49), 8704-8708. [Abstract]
Kocalka, Petr; Andersen, Nicolai Krog; Nielsen, Poul. Synthesis, molecular modeling studies and properties of oligonucleotides containing 5-(1H-1,2,3-triazol-4-yl)-2'-deoxyuridine derivatives. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
Steffansen, Signe Inglev; Albek, Nanna; Nielsen, Poul. Synthesis of conformationally restricted nucleic acid fragments using Ring-closing alkene, alkyne and enyne metathesis reactions. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
Andersen, Charlotte; Nielsen, Poul. Double-headed nucleosides with thymine in the 2'-position. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
Kumar, Niti; Nielsen, Jakob T.; Maiti, Souvik; Petersen, Michael. i-motif formation with locked nucleic acid (LNA). Angewandte Chemie, International Edition (2007), 46(48), 9220-9222. [Abstract]
Lebars, Isabelle; Husson, Clotilde; Yoshizawa, Satoko; Douthwaite, Stephen; Fourmy, Dominique. Recognition elements in rRNA for the tylosin resistance methyltransferase RlmAII. Journal of Molecular Biology (2007), 372(2), 525-534. [Abstract]
Umemoto, T., Hrdlicka, P. J., Babu, B. R., Wengel, J. "Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: Lessons to be learned", ChemBioChem (2007), 8, 2240-2248 [Abstract]
Prasad, A. K., Singh, S. K., Kalra, N., Singhal, N., Wengel, J. and Parmar, V. S. "Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides", Nucleosides Nucleotides Nucleic Acids, (2007) 1517-1521 [Abstract]
Kumar, T. S., Madsen, A. S., Wengel, J., Hrdlicka, P.J. "Synthesis and biophysical studies of N2'-functionalized 2'-amino-α-L-LNA", Nucleosides Nucleotides Nucleic Acids, (2007), 26, 1403-1405 [Abstract]
Kumar, T. S., Wengel, J., Hrdlicka, P.J. "Pyrene-functionalized 2'-amino-α-L-LNA as potentioal diagnostic probes", Nucleosides Nucleotides Nucleic Acids, (2007), 26, 1407-1409 [Abstract]
Donini, S., Clerici, M., Wengel, J., Vester, B. and Peracchi, A. "The advantages of being locked: assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes" JBC, (2007), 282, 35510-35518 [Abstract]
Veedu, R. N., Vester, B., Wengel J. “In vitro incorporation of LNA nucleotides“, Nucleosides Nucleotides Nucleic Acids (2007), 26, 1207-1210 [Abstract]
Kocalka, P., Andersen, N. K., Jensen, F. and Nielsen, P. Synthesis of 5-(1,2,3-Triazol-4-yl)-2'-deoxyuridines by a click chemistry approach: stacking of triazoles in the major groove gives increased nucleic acid duplex stability. ChemBioChem (2007), 8, 2106-2116 [Abstract]
Umemoto, T., Hrdlicka, P. J., Babu, B. R. and Wengel, J. Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned. ChemBioChem (2007), Articles online in advance of print [Abstract]
Veedu, R. N., Vester, B. and Wengel, J. Novel applications of locked nucleic acids. Nucleic Acids Symposium Series (2007), 51, 29-30. [Abstract]
Geci, I., Filichev, V.V., Pedersen, E. B. Stabilization of parallel triplexes by twisted intercalating nucleic acids (TINAs) incorporating 1,2,3-triazole units and prepared by microwave-accelerated click chemistry. Chem. Eur. J. (2007), 13, 6379-6386. [Abstract]
Aly, Y. L., Pedersen, E. B., La Colla, P., Loddo, R. Novel synthesis and anti-HIV-1 activity of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs). Synthesis (2007), 13, 1955-1960. [Abstract]
Kalek, M., Madsen, A. S., Wengel, J. Effective Modulation of DNA Duplex Stability by Reversible Transition Metal Complex Formation in the Minor Groove. J. Am. Chem. Soc. (2007), 129, 9392-9400. [Abstract]
Nishimura, K., Johansen, S. K., Inaoka, T., Hosaka, T., Tokuyama, S., Tahara, Y., Okamoto, S., Kawamura, F., Douthwaite, S., Ochi, K. Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants. J. Bact. (2007), 189, 6068-6073. [Abstract]
Douthwaite, S., Johansen, S. K., Van Wezel, G. P. Antibiotics and methods for producing them. PCT Int. Appl. (2007), 90pp, WO 2007084002.
Auxilien, S., El Khadali, F., Rasmussen, A., Douthwaite, S., Grosjean, H. Archease from Pyrococcus abyssi Improves Substrate Specificity and Solubility of a tRNA m5C Methyltransferase. J. Bio. Chem. (2007), 282, 18711-18721. [Abstract]
Douthwaite, S., Kirpekar, F. Identifying Modifications in RNA by MALDI Mass Spectrometry. Methods in Enzymology (2007), 425, 1-20. [Abstract]
Christiansen, J.K., Lobedanz, S., Arar, K., Wengel, J. and Vester, B.
LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes. Bio. Med. Chem. (2007), 15, 6135-43. [Abstract]
Kumar, T.S., Wengel, J. and Hrdlicka, P.J. 2’-N-(Pyren-1-yl)acetyl-2’-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets. ChemBioChem (2007), 8, 1122-25 [Abstract]
Højland, T., Kumar, S., Babu, B. R., Umemoto, T., Albæk, N., Sharma, P.K., Nielsen, P. and Wengel, J. LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides. Org. Biomol. Chem., Advance articles, June 2007. [Abstract]
Holm, A. I. S., Worm, E. S., Ckakraborty, T., Babu, B. R., Wengel, J., Vrønning Hoffmann, S., Brøndsted Nielsen, S. On the influence of conformational locking of sugar moieties on the absorption and circular dichroism of nucleosides from synchrotron radiation experiments. J. Photochem. Photobiol. A. (2007), 187, 293-298. [Abstract]
Veedu, Rakesh N.; Vester, Birte and Wengel, Jesper. Enzymatic Incorporation of LNA Nucleotides into DNA Strands. ChemBioChem (2007), 8, 490-492. [Abstract]
Aly, Youssef L.; Pedersen, Erik B.; La Colla, Paolo; Loddo, Roberta. Synthesis and anti-HIV-1 activity of 1,3-phenylene bis-uracil analogs of MKC-442. J. Hetero. Chem. (2007), 44, 381-387.
Therkelsen, Frans; Jorgensen, Per T.; Nielsen, Claus; Pedersen, Erik B.. New Emivirine (MKC-442) Analogues Containing a Tetrahydronaphthalene at C-6 and their Anti-HIV Activity. Monatshefte fuer Chemie (2007), 138, 495-503. [Abstract]
Aly, Youssef L.; Pedersen, Erik B.; La Colla, Paolo; Loddo, Roberta. Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group. Archiv der Pharmazie (2007), 340, 225-235. [Abstract]
Jakobsen, Martin R.; Haasnoot, Joost; Wengel, Jesper; Berkhout, Ben; Kjems, Joergen. Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology (2007), 4, 29 [Abstract]
Prasad, Ashok K.; Kalra, Neerja; Yadav, Yogesh; Kumar, Rajesh; Sharma, Sunil K.; Patkar, Shamkant; Lange, Lene; Wengel, Jesper; Parmar, Virinder S. Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides. Chem. Comm. (2007), 25, 2616-2617. [Abstract]
Holm, Anne I. S.; Worm, Esben S.; Chakraborty, Tapas; Babu, B. Ravindra; Wengel, Jesper; Hoffmann, Soren Vronning; Nielsen, Steen Brondsted. On the influence of conformational locking of sugar moieties on the absorption and circular dichroism of nucleosides from synchrotron radiation experiments. Journal of Photochemistry and Photobiology, A: Chemistry (2007), 187, 293-298. [Abstract]
Christensen, Mikkel S.; Madsen, Charlotte M. and Nielsen, Poul. Synthesis and modelling of DNA junction and minor groove zipper motifs incorporating the double-headed nucleoside 5 (S)–C-(thymine-1-ylmethyl)thymidine. Org. Biomol. Chem. (2007) 5, 1586–1594. [Abstract]
Grubb, Mikala; Wackerbarth, Hainer; Wengel, Jesper; Ulstrup, Jens. Direct Imaging of Hexaamine-Ruthenium(III) in Domain Boundaries in Monolayers of Single-Stranded DNA. Langmuir (2007), 23, 1410-1413. [Abstract]
Veedu Rakesh N; Vester Birte; Wengel Jesper. Enzymatic Incorporation of LNA Nucleotides into DNA Strands. ChemBioChem (2007), 8, 490-492.[Abstract]
Kaur, Harleen; Wengel, Jesper; Maiti, Souvik. LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state. Biochemical and Biophysical Research Communications (2007), 352(1), 118-122. [Abstract]
Jensen Søren S; Ariza Xavier; Nielsen Poul; Vilarrasa Jaume; Kirpekar Finn Collision-induced dissociation of cytidine and its derivatives. Journal of mass spectrometry: JMS (2007), 42(1), 49-57. [Abstract]