Cancer
Lund, R. R., Terp, M. G., Laenkholm, A. V., Jensen, O. N., Leth-Larsen, R., and Ditzel, H. J. (2012) Quantitative proteomics of primary tumors with varying metastatic capabilities using stable isotope-labeled proteins of multiple histogenic origins. Proteomics 12, 2139-2148.
Leth-Larsen, R., Lund, R. R., and Ditzel, H. J. (2010) Plasma membrane proteomics and its application in clinical cancer biomarker discovery. Mol Cell Proteomics 9, 1369-1382.
Lund, R., Leth-Larsen, R., Jensen, O. N., and Ditzel, H. J. (2009) Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers. J Proteome Res 8, 3078-3090.
Metabolism
Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., De Filippis, E. A., Roberts, C., Smoke, C. C., Meyer, C., Hojlund, K., Yi, Z., and Mandarino, L. J. (2010) Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes 59, 33-42.
Hojlund, K., Bowen, B. P., Hwang, H., Flynn, C. R., Madireddy, L., Geetha, T., Langlais, P., Meyer, C., Mandarino, L. J., and Yi, Z. (2009) In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res 8, 4954-4965.
Lefort, N., Yi, Z., Bowen, B., Glancy, B., De Filippis, E. A., Mapes, R., Hwang, H., Flynn, C. R., Willis, W. T., Civitarese, A., Hojlund, K., and Mandarino, L. J. (2009) Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. J Proteomics 72, 1046-1060.
Method development
Engholm-Keller, K., Hansen, T. A., Palmisano, G., and Larsen, M. R. (2011) Multidimensional strategy for sensitive phosphoproteomics incorporating protein prefractionation combined with SIMAC, HILIC, and TiO(2) chromatography applied to proximal EGF signaling. J Proteome Res 10, 5383-5397.
Parker, B. L., Palmisano, G., Edwards, A. V., White, M. Y., Engholm-Keller, K., Lee, A., Scott, N. E., Kolarich, D., Hambly, B. D., Packer, N. H., Larsen, M. R., and Cordwell, S. J. (2011) Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment. Mol Cell Proteomics 10, M110 006833.
Palmisano, G., Lendal, S. E., Engholm-Keller, K., Leth-Larsen, R., Parker, B. L., and Larsen, M. R. (2010) Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry. Nat Protoc 5, 1974-1982.
Biomarker discovery
Kristensen, L. P., Chen, L., Nielsen, M. O., Qanie, D. W., Kratchmarova, I., Kassem, M., and Andersen, J. S. (2012) Temporal profiling and pulsed SILAC labeling identify novel secreted proteins during ex vivo osteoblast differentiation of human stromal stem cells. Mol Cell Proteomics.
Cangemi, C., Skov, V., Poulsen, M. K., Funder, J., Twal, W. O., Gall, M. A., Hjortdal, V., Jespersen, M. L., Kruse, T. A., Aagard, J., Parving, H. H., Knudsen, S., Hoilund-Carlsen, P. F., Rossing, P., Henriksen, J. E., Argraves, W. S., and Rasmussen, L. M. (2011) Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes. Clin Chem 57, 1556-1565.