8 May 2017
Professor Susanne Mandrup has received 65 million DKK from the Danish National Research Foundation to establish a new Center of Excellence – “Center for Functional Genomics and Tissue Plasticity” – ATLAS.
In this Center of Excellence, we will investigate how specific cell types in the liver and fat tissues change their properties during development of obesity and fatty liver disease. We will use a combination of advanced functional genomics technologies, transgenic mouse models, proteomics and bioinformatics to uncover the fascinating plasticity of cells.
Our vision is to obtain fundamentally new insight into plasticity of cells in the tissue context and to translate this knowledge into the clinical setting to improve our understanding, diagnosis and treatment of obesity-related diseases.
The official announcement of the granting of ATLAS was celebrated at the Department of Biochemistry and Molecular Biology April 19, 2017, where both the Head of Department Peder Thusgaard Ruhoff and the Dean of Faculty of Science Martin Zachariasen used the opportunity to congratulate Susanne and the entire ATLAS team with the outstanding achievement and thank them of getting a Center of Excellence to SDU.
The good news has also been announced on the SDU homepage - New Center of Excellence
The new Center of Excellence consists of researchers from both the Faculty of Science, the Faculty of Health Science and Odense University Hospital:
Research leaders associated with ATLAS:
Department of Biochemistry and Molecular Biology, Faculty of Science:
Prof. Susanne Mandrup, Assoc. Prof. Lars Grøntved, Asst. Professor Kim Ravnskjær, Prof. Blagoy Blagoev
Department of Mathematics and Computer Science, Faculty of Science:
Assoc. Prof. Jan Baumbach
Department of Molecular Medicine, Faculty of Health Science:
Prof. Søren Kragh Moestrup, Assoc. Prof. Jonas Graversen
Department of Clinical research, Medical Gastroenterology, Odense University Hospital:
Prof. and Physician Aleksander Krag
4 May 2017
4 May 2017
Our manuscript “Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation” is now out in Molecular Cell.
In this study, we have used promoter capture Hi-C to for the first time demonstrate a rapid and dynamic rewiring of promoter-enhancer loops in response to differentiation stimuli. We show that rather than being pre-established promoter-anchored chromatin loops are dynamically rewired during early differentiation of 3T3-L1 preadipocytes. The establishment of new promoter-enhancer loops is tightly coupled to activation of enhancers, as evidenced by recruitment of co-activators and acquisition of active histone marks, as well as to activation of gene expression from the promoters. Intriguingly, formation of loops connecting activated enhancers and promoters is also associated with extensive recruitment of corepressors such as NCoR and HDACs, indicating that this class of coregulators may play a previously unrecognized role during enhancer activation.
Please click on the graphical abstract below to read more
27 April 2017
Emilie Kristine Bagge has successfully defended here PhD thesis and got a well deserved place at our Hall of Fame. Congratulations to Emilie, who will continue her scientific career in Japan the next couple of years. We wish you all the best!
25 March 2017
Danish Diabetes Academy Visiting Professor James Granneman from Molecular Medicine and Genetics and Internal Medicine, Wayne State University School of Medicine will arrive and stay until the end of April. Welcome!
10 March 2017
Sofie Traynor successfully defended her PhD thesis "Function and Genomic Interactome of Early Adipogenic Transcription Factor Hotspots "
24 February 2017
Kim Ravnskjær received 200.000 DKK from the Augustinus Foundation for the project: “Identification of fibrose-associated membrane receptors in the liver and investigation of their potential in treatment of chronic liver disease”.
1 February 2017
Sofie Marchsteiner Bendixen is now a PhD student with Kim Ravnskjær as her supervisor.
1 February 2017
Stine Marie Præstholm is now a PhD student with Lars Grøntved as her supervisor.
17 January 2017
Our manuscript “Genome-wide insights into development and function of thermogenic adipocytes” is now out in Trends in Endocrinology and Metabolism. Please click on the cover picture below to read more.
15 January 2017
Lasse Markussen is now a PhD student in the Mandrup Group.
4 January 2017
Results of the annual comptetition of the group's cleanest/ tidiest office and the most welcoming office :
Mette Larsen is now a PhD student in the Mandrup Group.
28 November 2016
We had our yearly Christmas-hygge day in the Group
11 November 2016
James Granneman, Professor of Molecular Medicine and Genetics and of Internal Medicine, Wayne State University School of Medicine is appointed Danish Diabetes Academy Visiting Professor in the group in 2017
7 November 2016
Our manuscript “Genome-wide insights into development and function of thermogenic adipocytes” was accepted by Trends in Endocrinology and Metabolism
3 November 2016
Our manuscript "The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation" has been accepted by Nucleic Acids Research