Susanne Mandrup has been Professor at Department of Biochemistry and Molecular Biology, University of Southern Denmark since 2008. She obtained her PhD in Biochemistry from Odense University in 1992 and worked as a post doc among others in Prof. M. Daniel Lane’s group, Department of Biological Chemistry, Johns Hopkins University, Baltimore 1995-96. In 1996 she was recruited back to Odense as Assistant Professor, and in 1999 she was promoted to Associate Professor.
Susanne Mandrup received a Sapere Aude Advanced Grant in 2012 from the Danish Independent Research Council and is heading several other large scale research initiatives. She is one of the leading figures in the newly established Danish Diabetes Academy and is involved in several other national and international research consortia. She was member of the Danish Natural Science Research Council (2005 – 2010) and has since 2009 been member of The Medical and Natural Science Committee of the Novo Nordisk Foundation. In addition, she has served on several grant review panels under FP6 and FP7 and is currently member of the European Research Council panel for Genetics, Genomics, Bioinformatics and Systems Biology, from 2015 as Panel Chair for the Consolidator Panel.
Head of research: Professor Susanne Mandrup
Postdoc Alexander Rauch
Postdoc Rasmus Siersbæk
Postdoc Søren Fisker Schmidt
Postdoc Sungmin Lee
Postdoc Anders Kristian Haakonsson
Academic staff (Laboratory Manager) Ronni Nielsen
Secretary Vibeke Jensen
Laboratory trainee Niels Mahler Kristiansen
PhD fellow Ann-Britt Marcher
PhD fellow Anne Loft
PhD fellow Bjørk Ditlev Larsen
PhD fellow Sofie Traynor
PhD student Emilie Kristine Bagge
PhD student Jesper Grud Skat Madsen
PhD fellow Signe Bek (co-supervisor)
PhD fellow Ann-Sofie Bøgh Larsen
PhD fellow Isabel Forss
Research Assistant Maria Stahl Madsen
Guest PhD student Christian Bindesbøll
Transcriptional networks in the regualtion of differentiation and metabolism
The research in the Mandrup Group focuses on understanding transcriptional networks regulating metabolism and stem cell development of mammalian cells. We are specifically interested in the molecular cross-talk between transcriptional regulation and metabolism in fat cells and the insulin-produing beta-cells in the pancreas, and in the transcriptional network regulating fat cell development. Fat cells and beta-cells play a central role in the etiology of insulin resistance and type II diabetes, and maintenance of proper carbohydrate/lipid homeostasis in these cells are of outmost importance for whole body physiology. The mechanisms of action and the gene regulatory programs initiated by members of the peroxisome proliferator activated receptor (PPAR) family and their associated co-factors are of particular interest. In addition, the Mandrup laboratory has a long-standing interest in the acyl-CoA binding protein (ACBP).
Current research projects
For more information on current research projects in the Mandrup group pelase visit the Mandrup group website.
Extensive chromatin remodeling and establishment of transcription factor ‘hotspots’ during early adipogenesis
Siersbæk, R.; Nielsen, R.; John, S.; Sung, M.-H.; Baek, S.; Loft, A.; Hager, G. L.; Mandrup, S., EMBO J, 2011, 30, 1459-72
Delayed hepatic adaptation to weaning in ACBP-/- mice is caused by disruption of the epidermal barrier
Neess, D.; Bek, S.; Marcher, A.-B.; Bloksgaard, M.; Færgeman, N.; Mandrup, S., Cell Reports, 2013, 5, 1403-1412
Transcription factor cooperativity in early adipogenic hotspots and super-enhancers
Siersbæk, R.; Rabiee, A.; Nielsen, R.; Sidoli, S.; Loft, A.; Poulsen, L. L. C.; Rogowska-Wrzesinska, A.; Jensen, O. N.; Mandrup, S., Cell Reports, 2014, 7(5), 1413-1455
A full list of publications by professor Susanne Mandrup can be found here.