Forskningsområder
Forskningsområder
Genetisk epidemiologi, tvillingstudier, aldringsforskning, aldersrelaterede sygdomme, reproduktionsepidemiologi, medfødte misdannelser, læbe-ganespalte og føtal programmering.
Udvalgte faglige tillidsposter
- Leder af Det Danske Tvillingregister, 2007-
- Leder af Dansk Center for Aldringsforskning, 2008-
- Medlem af styregruppen for NIA- LLFS Long Life Family Study, National Institutes of Health, National Institute on Aging, USA, 2004-
- Work package leader for projektet LifeSpan Network, 2007-
- Medlem af Akademisk Råd, Syddansk Universitet, 2004-
- Medlem af bestyrelsen for The International Society for Twin Studies (ISTS), 2010-
- Adjungeret professor i aldringsepidemiologi ved Institut for Folkesundhedsvidenskab, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, 2011-
Udvalgte publikationer
Christensen K, Pedersen JK, Hjelmborg JV, Vaupel JW, Stevnsner T, Holm NV, Skytthe A. Cancer and longevity- is there a trade-off? A study of co-occurrence in Danish twin pairs born 1900-1918. The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2012;67(5):489-94.
Petersen I, Nielsen MM, Beck-Nielsen H, Christensen K. No evidence of a higher 10 year period prevalence of diabetes among 77,885 twins compared with 215,264 singletons from the Danish birth cohorts 1910-1989. Diabetologia 2011; 54(8):2016-24.
Jacobsen R, Martinussen T, Christiansen L, Jeune B, Andersen-Ranberg K, Vaupel JW, Christensen K. Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes - Two nationwide cohort studies. Aging Cell 2010; 9(6):1004-9.
Grosen D, Chevrier C, Skytthe A, Bille C, Molsted K, Sivertsen A, Murray JC, Christensen K. A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance. Journal of Medical Genetics 2010; 47(3):162-8.
Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: the challenges ahead. Lancet 2009;374:1196-1208.
Christensen K, Thinggaard M, McGue M, Rexbye H, Hjelmborg J, Aviv A, Gunn D, V d Ouderaa F, Vaupel JW. Perceived age as clinically useful biomarker of ageing: cohort study. BMJ 2009; 339: b5262.
Oksuzyan A, Petersen I, Støvring H, Bingley P, Vaupel JW, Christensen K. The male-female health-survival paradox: A survey and register study of the impact of sex-specific selection and information bias. Annals of Epidemiology 2009;19(7):504-511(selected as the best article during 2009 in the Annals of Epidemiology).
Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW. Exceptional longevity does not result in excessive levels of disability. Proceedings of the National Academy of Sciences 2008; 105(36):13274-9.
Christensen K, Murray JC. What genome-wide association studies can do for medicine.
New England Journal of Medicine 2007;356(11):1094-1097.
Christensen K, Johnson TE, Vaupel JW. The quest for genetic determinants of human longevity: challenges and insights. Nature Reviews Genetics 2006;7:436-448.
Publikationer
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FORAPPROVAL
Genetisk epidemiologi.
/
Christensen, Kaare; Kruse, Torben A
.
I: Medicinsk genetik. red. / Søren Nørby ; Peter K.A. Jensen. Vol. 1 2. udg. København : FADL's Forlag, 2012. s. 127-146.
Publikation
:
Undervisning - peer review
›Bidrag til bog/antologi
CREATED
UCP3 polymorphisms, hand grip performance and survival at old age: Association analysis in two Danish middle aged and elderly cohorts.
/
Dato, Serena; Sørensen, Mette
; Montesanto, A ; Lagani, V
; Christiansen, Lene; Christensen, Kaare
.
I
: Mechanisms of Ageing and Development
, 2012.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Cognitive function in families with exceptional survival.
/ Barral, Sandra ; Cosentino, Stephanie ; Costa, Rosann ; Matteini, Amy
; Christensen, Kaare
; Andersen, Stacy L ; Glynn, Nancy W ; Newman, Anne B ; Mayeux, Richard.
I
: Neurobiology of Aging
, Vol. 33, Nr. 3, 2012, s. 619 e1-610 e7.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
CREATED
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
/
Soerensen, Mette; Dato, Serena; Tan, Qihua; Thinggaard, Mikael
; Kleindorp, Rabea ; Beekman, Marian ; Suchiman, H Eka D
; Jacobsen, Rune; McGue, Matt
; Stevnsner, Tinna V. ; Bohr, Vilhelm ; de Craen, Anton J M ; Westendorp, Rudi G J ; Schreiber, Stefan ; Slagboom, P Eline ; Nebel, Almut
; Vaupel, James W; Christensen, Kaare; Christiansen, Lene
.
I
: Age (Omaha)
, 12.01.2012.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes : Cross sectional and longitudinal studies.
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Soerensen, Mette; Dato, Serena; Tan, Qihua; Thinggaard, Mikael
; Kleindorp, Rabea ; Beekman, Marian
; Jacobsen, Rune
; Suchiman, H Eka D ; de Craen, Anton J M ; Westendorp, Rudi G J ; Schreiber, Stefan ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Slagboom, P Eline ; Nebel, Almut
; Vaupel, James W; Christensen, Kaare; McGue, Matt; Christiansen, Lene
.
I
: Experimental Gerontology
, Vol. 47, Nr. 5, 05.2012, s. 379-87.
Publikation
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Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity : a cross-sectional and longitudinal analysis.
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Soerensen, Mette; Thinggaard, Mikael; Nygaard, Marianne; Dato, Serena; Tan, Qihua; Hjelmborg, Jacob; Andersen-Ranberg, Karen
; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Kimura, Masayuki ; Aviv, Abraham
; Christensen, Kaare; Christiansen, Lene
.
I
: Aging Cell
, Vol. 11, Nr. 2, 04.2012, s. 223-7.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Associations between inflammatory markers, candidate polymorphisms and physical performance in older Danish twins.
/ Tiainen, Kristina
; Thinggaard, Mikael
; Jylhä, Marja
; Bladbjerg, Else; Christensen, Kaare; Christiansen, Lene
.
I
: Experimental Gerontology
, Vol. 47, Nr. 1, 2012, s. 109-115.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Cancer and Longevity--Is There a Trade-off? : A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918.
/
Christensen, Kaare; Pedersen, Jacob K; Hjelmborg, Jacob V B; Vaupel, James W
; Stevnsner, Tinna V.
; Holm, Niels V; Skytthe, Axel
.
I
: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
, Vol. 67, Nr. 5, 2012, s. 489-94.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons.
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Mengel-From, Jonas; Thinggaard, Mikael; Christiansen, Lene; Vaupel, James W
; Orstavik, Karen Helene
; Christensen, Kaare
.
I
: European Journal of Human Genetics
, Vol. 20, Nr. 3, 01.03.2012, s. 361-4.
Publikation
:
Forskning - peer review
›Tidsskriftartikel
FORAPPROVAL
High-Resolution Genome-Wide Linkage Mapping Identifies Susceptibility Loci for BMI in the Chinese Population.
/ Zhang, Dong Feng ; Pang, Zengchang
; Li, Shuxia; Thomassen, Mads
; Wang, Shaojie ; Jiang, Wengjie
; Hjelmborg, Jacob V B; Kruse, Torben A; Kyvik, Kirsten O; Christensen, Kaare; Tan, Qihua
.
I
: Obesity
, Vol. 20, Nr. 4, 04.2012, s. 830-3.
Publikation
:
Forskning - peer review
›Tidsskriftartikel