Projects (selected):
Diabetes group
- Patophysiology of T2D. Henning Beck-Nielsen
- Mechanism of action of metformin. Ole Hother Nielsen, Kurt Højlund, Henning Beck-Nielsen
- Individual tailored treatment in T2D. Hennning Beck-Nielsen, Jan Erik Henriksen, Jens Steen Nielsen and Jacob Stiesen
- Health economics in care for diabetes in Denmark, Henning Beck-Nielsen, Jens Steen Nielsen and Jørgen Lauritzen
- DD2 - Danish Center for Strategic Research in T2D in Denmark. Epidemiological and intervention studies. Henning Beck-Nielsen, Jan Erik Henriksen and Jens Steen Nielsen.
- Lactateacidosis in Metformin treated subjects. Henning Beck Nielsen and Abdellatif Aharaz.
- Amputations in Funen 1995 - 2010. Henning Beck-Nielsen, Knud Bonnet Yderstræde and Ditlev F.G. Jensen.
- LADA - epidemiology and follow up investigations. Kurt Højlund, Henning Beck-Nielsen, Knud Bonnet Yderstræde, Mette Wod and Torben Hansen.
- Patofysiologi til insulinresistens i skeletmuskulatur ved polycystisk ovariesyndrom (PCOS). Studier af de molekylærbiologiske årsager til insulinresistens ved anvendelse af et fysiologisk modelsystem af humane muskelceller i kultur. Mette Brandt Eriksen, Michael Gaster, Henning Beck-Nielsen
- Lipoprotein Lipase mutations - causes and metabolic and clinical implications. Henning Beck Nielsen, Niels Færgemand and Kurt Højlund.
- RISC follow up: Insulin resistance and cardiovascular diseases. Kurt Højlund and Henning Beck-Nielsen.
- Consequences of intra uterine hyperglycemia for outcome. Dorte Møller Jensen, Henning Beck-Nielsen and Kurt Højlund.
- Telemedical solutions in diabetes. Knud Bonnet Yderstræde and Benjamin Schnack Rasmussen.
- SDHDS (South Danish Hypertension and Diabetes Study). Christina Stolzenburg Oxlund, Ib Abildgaard Jacobsen and Jan Erik Henriksen.
- Studies of insulin signalling and glycogen synthase phosphorylation in skeletal muscle in mono-zygote twins discordant for type 2 diabetes and patients with insulin receptor mutation. Kurt Højlund, Birgitte Vind
- South Danish Diabetes Study. Jan Erik Henriksen , Henning Beck-Nielsen and Knud Bonnet Yderstræde
- Prevalence of Macrovascular Disease in Type 2 Diabetes Mellitus. Mikael Kjær Poulsen and Jan Erik Henriksen
- Mass spectrometry based characterization of skeletal muscle proteome, mitoproteome, phosphoproteome, and phosphotyrosine proteome, and quantitative studies in individuals with insulin resistance. Kurt Højlund , Zhengping Yi, and Lawrence Mandarino)
- Discovery-mode and targeted characterization of mitochondrial phosphoproteins and its relation to insulin resistance in skeletal muscle and adipose tissue of patients with type 2 diabetes using mass spectrometry based quantitative phosphoproteomics. Kurt Højlund, Ole Nørregaard Jensen.
- Effect of endurance training, acute exercise and acute hyperglycemia on oxidative stress assessed by global proteomic characterization of protein carbonylation, insulin signaling, phosphorylation of glycogen synthase and AMPK in skeletal muscle of patients with type 2 diabetes. Kurt Højlund, Hans C. Beck, Jørgen F.P. Wojtaszewski.
- Studies of lipid droplets and SNARE proteins in skeletal muscle and adipose tissue, and their roles in the pathogenesis of insulin resistance in obesity and type 2 diabetes. Kurt Højlund, Pontus Boström, Sven-Olof Olofsson.
- Patofysiologien til insulinresistens i skeletmuskulatur hos type 2 diabetes patienter: Studier af de molekylærbiologiske årsager til insulinresistens ved anvendelse af et fysiologisk modelsystem af humane muskelceller i kultur. Michael Gaster Plasmin in urine - a new biomarker and target for renal protection in diabetes. Henrik Andersen, Jan Erik Henriksen and Boye Jensen.
- Self-care behaviour treatment in patients with type 2 diabetes. Lisbeth Minet and Jan Erik Henriksen
KMEB
- The physiological role of Telomerase in mesenchymal (stromal) stem cell biology in vitro, and bone homeostasis in vivo.
- Function of Dlk1/Pref-1/FA1 in stem cell differentiation and in bone biology.
- Relationship between osteoblast and adipocyte differentiation of bone marrow mesenchymal stem cells and new approaches for enhancing bone formation by inhibiting adipogenesis.
- Defining the phenotype of human mesenchymal stem cells using quantitative proteomics.
- Production of hESC reporter cell lines to study lineage-specific differentiation.
- Developing novel approaches to enhance in vivo homing of stem cells to injured sites to enhance tissue regeneration
- Enhancing osteoblast differentiation of mesenchymal stem cells using nano-surfaces-based scaffolds.
Clinical nursing group
Pituitary gland and nutrition group
- Androgen and Growth Factor Study of Elderly Men – Biomolecular study of androgen and growth factor influence on body composition muscle function and bone metabolism in men 60-70 years of age. Kristian Wraae
- Comparable effects of Lanreotide Autogel and Octreotide LAR on GH IGF-I levels and Patient satisfaction. Marianne Andersen
- Funen Anorexia Nervosa Study - Retrospective Cohorte Study and 10-year follow-up study. René Støving
- Body composition, glucose metabolism, insulin resistance and gene expression in muscle cells in healthy overweight women. Dorte Glintborg
- Prospective study of patients with hirsutism. Magdalena Andries
- Cannabinoid CB1 receptor agonist treatment in severe chronic anorexia nervosa:A randomized, placebo-controlled, double-blind, crossover study. Eudra-CT number: 2007-005631-29. 2009. René Støving
- Bone microarchitecture in anorexia nervosa. 2010. René Støving
Osteoporosis group
Kim Brixen og Pernille Hermann
Thyroid group
- Studies of thyroid-specific health-related quality of life in patients with thyroid disorders. Steen Bonnema and Laszlo Hegedüs
- Etiology and consequences of thyroid diseases, as assessed by studying thyroid disease discordant twins. Thomas Brix and Laszlo Hegedüs
- Effects and side effects of B cell depletion with rituximab (anti-CD20 antibodies) in autoimmune thyroid disorders. Laszlo Hegedüs
- Effects and side effects of recombinant human TSH (rhTSH)-augmented radioioiodine therapy in benign goitre. Steen Bonnema and Laszlo Hegedüs
- Ultrasound-guided diagnostic and therapeutic procedures in patients with thyroid and parathyroid disorders. Laszlo Hegedüs
- Interrelation between genetic and environmental factors in the etiology of thyroid disorders. Thomas Brix and Laszlo Hegedüs